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Pathways Recommended:	PROTAC Antibody-drug Conjugate/ADC Related

Results for "

linker conjugates for PROTACs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (205) Drug-Linker Conjugates for ADC (2) E3 Ligase Ligand-Linker Conjugates (787) PROTAC-Linker Conjugates for PAC (10) PROTACs (63) Target Protein Ligand-Linker Conjugates (92) 17β-HSD (1) ADC Payload (1) Akt (3) Anaplastic lymphoma kinase (ALK) (2) Androgen Receptor (4) Apoptosis (178) ATM/ATR (2) Aurora Kinase (2) Autophagy (174) Bacterial (1) Bcl-2 Family (2) BCL6 (1) Btk (7) c-Met/HGFR (3) c-Myc (3) Casein Kinase (1) CCR (1) CDK (8) Checkpoint Kinase (Chk) (1) CRM1 (1) Cytochrome P450 (1) Deubiquitinase (1) DNA/RNA Synthesis (1) Drug Derivative (2) Drug Isomer (1) E1/E2/E3 Enzyme (2) EGFR (4) Enterovirus (1) Environmental Pollutants (1) Epigenetic Reader Domain (27) ERK (3) Estrogen Receptor/ERR (8) FAK (1) Ferroptosis (1) FGFR (1) FKBP (3) FLT3 (4) Fluorescent Dye (1) Glutathione Peroxidase (2) HDAC (5) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (2) Histone Demethylase (1) Histone Methyltransferase (4) HIV (1) HSP (1) HyT (1) IAP (4) IKK (1) IKZF Family (1) JAK (2) Ligands for E3 Ligase (5) Ligands for Target Protein for PROTAC (20) MAGL (1) MAP4K (2) Mixed Lineage Kinase (2) NF-κB (1) Oxysterol-binding Protein-related Protein (ORP) (1) PARP (1) PD-1/PD-L1 (1) PI3K (1) PIKfyve (1) Pim (1) Pregnane X Receptor (PXR) (2) PROTAC Linkers (206) Ras (5) Reference Standards (14) RET (2) RIP kinase (2) SARS-CoV (1) SGK (2) SOS1 (1) Src (1) STAT (5) SWI/SNF Complex (3) Virus Protease (1) WDR5 (1) Wee1 (1) Wnt (1) YAP (3) YTHDF (1) β-catenin (1)
By Research Areas:	Cancer (1083) Infection (11) Inflammation/Immunology (30) Metabolic Disease (2) Neurological Disease (3)
Click Chemistry:	ADC Synthesis (52) TCO (2) DBCO (10) PROTAC Synthesis (62) BCN (1) Azide (60) Alkynes (30)
Oligonucleotides:	Pegylated Lipids (1)

1187

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

104

Click Chemistry

Oligonucleotides

Targets Recommended: Target Protein Ligand-Linker Conjugates PROTAC-Linker Conjugates for PAC ADC Linker Drug-Linker Conjugates for ADC E3 Ligase Ligand-Linker Conjugates PROTACs Antibody-Drug Conjugates (ADCs) Peptide-Drug Conjugates (PDCs) Radionuclide-Drug Conjugates (RDCs) Antibody-Oligonucleotide Conjugates (AOCs)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138632

**PROTAC BRD4 Degrader linker conjugate**	PROTACs Epigenetic Reader Domain PROTAC-Linker Conjugates for PAC	Cancer
PROTAC BRD4 Degrader linker conjugate is a linker-payload conjugate as well as a bifunctional degrader of BRD4 that binds to VHL, consisting of *PROTAC* and a linker. PROTAC BRD4 Degrader linker conjugate can be conjugated with STEAP1 and CLL1 antibodies to degrade BRD4 protein, with DC₅₀ values of 0.86 nM and 7.6 nM, respectively. PROTAC BRD4 Degrader linker conjugate can be used in research related to prostate cancer and acute myeloid leukemia (BRD4 ligand: (HY-129939); VHL ligand: (HY-125845)) .\n

HY-175360

USP7 Ligand-Linker Conjugates 1	Target Protein Ligand-Linker Conjugates Deubiquitinase	Cancer
USP7 Ligand-Linker Conjugates 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for USP7 (HY-175359) and a PROTAC linker, which recruits E3 ligases. USP7 Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC USP7 Degrader-1 (HY-175358) .

HY-W1006706

E3 Ligase Ligand-linker Conjugate 157	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 157 is the conjugate composed of the E3 ligase ligand and the linker. E3 Ligase Ligand-linker Conjugate 157 can be used for synthesis of PROTAC degrader KT-253 (HY-170451) .

HY-175766

CRBN Ligand-Linker Conjugate 2	E3 Ligase Ligand-Linker Conjugates	Inflammation/Immunology
CRBN Ligand-Linker Conjugate 2 is a synthesized E3 ligand-linker conjugate that can be used for synthesis of PROTACs, such as FIP22 (HY-175764). FIP22 is a potent and selective IRAK4 PROTAC degrader with anti- atopic dermatitis activity .

HY-W034918

Docosanedioic acid	ADC Linker PROTAC Linkers	Cancer
Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-176918

K-Ras ligand-Linker Conjugate 8	Target Protein Ligand-Linker Conjugates Ras	Cancer
K-Ras ligand-Linker Conjugate 8 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for KRAS (HY-162960) and a PROTAC linker, which recruits E3 ligases. K-Ras ligand-Linker Conjugate 8 can be used for synthesis of PROTAC KRAS(on) degrader ACBI-4 (HY-176792) .

HY-175726

BRAF ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates	Cancer
BRAF ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used to synthesize PROTAC CST905(HY-175435) .

HY-175551

HPK1 ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates MAP4K	Cancer
HPK1 ligand-Linker Conjugate 1 is a synthesized target protein ligand-linker conjugate that can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-5 (HY-175547). PROTAC HPK1 Degrader-5 is a potent and orally active HPK1 PROTAC degrader with anti-tumor activity .

HY-133046

VHL Ligand-Linker Conjugates 17	E3 Ligase Ligand-Linker Conjugates	Cancer
VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader . VHL Ligand-Linker Conjugates 17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-179244

E3 Ligase Ligand-linker Conjugate 215	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 215 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 215 can be used to synthesize STAT3 PROTAC Degrader S3D5 (HY-179243) .

HY-125906

VHL Ligand-Linker Conjugates 15 E3 Ligase Ligand-linker conjugates 56	E3 Ligase Ligand-Linker Conjugates	Cancer
VHL Ligand-Linker Conjugates 15 incorporates an VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 15 can be used to design PROTACs .

HY-175374

RIPK1 ligand-Linker Conjugate-1	Target Protein Ligand-Linker Conjugates RIP kinase	Cancer
RIPK1 ligand-Linker Conjugate-1 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for RIPK1 (HY-175371) and a PROTAC linker (HY-175373), which recruits E3 ligases. RIPK1 ligand-Linker Conjugate-1 can be used for synthesis of PROTAC RIPK1 Degrader-1 (HY-175370) .

HY-132943

BRD4 ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates	Cancer
BRD4 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used in the synthesis of PROTACs.

HY-176788

EGFR Ligand-Linker Conjugates 1	Target Protein Ligand-Linker Conjugates EGFR	Cancer
EGFR Ligand-Linker Conjugates 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for EGFR (HY-150905) and a PROTAC linker, which recruits E3 ligases. EGFR Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC EGFR degrader 3 (HY-144605) .

HY-178046

OSBP ligand-Linker Conjugate 1	Oxysterol-binding Protein-related Protein (ORP) Target Protein Ligand-Linker Conjugates	Cancer
OSBP ligand-Linker Conjugate 1 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for OSBP (HY-178035) and a PROTAC linker, which recruits E3 ligases. OSBP ligand-Linker Conjugate 1 can be used for synthesis of PROTAC OSBP Degrader-1 (HY-178034) .

HY-174409

HDAC6 ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates HDAC	Cancer
HDAC6 ligand-linker conjugate 1 is a conjugate of HDAC6 ligand and linker, which can be used to synthesize *PROTACs* such as PROTAC HDAC6 degrader 5 (HY-174401) .

HY-178311

EGFR Ligand-Linker Conjugates 4	Target Protein Ligand-Linker Conjugates EGFR	Cancer
EGFR Ligand-Linker Conjugates 4 is a conjugate of the EGFR ligand (HY-178313) and the linker. EGFR Ligand-Linker Conjugates 4 can be used for synthesizing PROTAC EGFR degrader 16 (HY-178242) .

HY-44148

FAK ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates	Cancer
FAK ligand-Linker Conjugate 1 incorporates a ligand for FAK, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). FAK ligand-Linker Conjugate 1 can be extensively used for PROTAC-mediated protein degradation .

HY-175333

c-Met ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates c-Met/HGFR	Cancer
c-Met ligand-Linker Conjugate 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for c-Met (HY-W425461) and a PROTAC linker (HY-151862), which recruits E3 ligases. c-Met ligand-Linker Conjugate 1 can be used for synthesis of PROTAC c-Met degrader-5 (HY-175320) .

HY-132943A

BRD4 ligand-Linker Conjugate 1 TFA	Target Protein Ligand-Linker Conjugates	Cancer
BRD4 ligand-Linker Conjugate 1 TFA (compound 106-1) is a target protein ligand-linker conjugate that can be used in the synthesis of PROTACs .

HY-128818

cIAP1 Ligand-Linker Conjugates 5 E3 ligase Ligand-linker conjugates 39	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 5 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 5 can be used to design SNIPERs .

HY-178888

Nrf2 ligand-Linker Conjugate 2	PROTAC-Linker Conjugates for PAC	Cancer
Nrf2 ligand-Linker Conjugate 2 is a synthesized Nrf2 ligand-linker conjugate that can be used for synthesis of PROTAC K-Ras Degrader-7 (HY-178873). PROTAC K-Ras Degrader-7 is a potent K-Ras PROTAC degrader with anti-tumor activity .

HY-170769

FLT3 Ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates FLT3	Cancer
FLT3 Ligand-Linker Conjugate 1 (compound 7) contains the FLT3 ligand and a PROTAC linker, which can recruit the E3 ligase VHL. FLT3 Ligand-Linker Conjugate 1 can be used to synthesize the PROTAC RSS0680 (HY-148062). PROTAC RSS0680 is a bifunctional compound that targets protein degradation of kinases .

HY-170987

FKBP12 Ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates FKBP	Cancer
FKBP12 Ligand-Linker Conjugate 1 is the conjugate composed of a target protein ligand for FKBP12 and a linker. FKBP12 Ligand-Linker Conjugate 1 can be used for synthesis of PROTAC degrader MC-25B (HY-170983) .

HY-138965A

Pomalidomide-5-C2-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-5-C2-NH2 (hydrochloride) is a conjugate of E3 ligase ligand and linker, which can be used for *PROTACs* synthesis .

HY-173370

MAGL Ligand-Linker Conjugate 1	E3 Ligase Ligand-Linker Conjugates	Others
MAGL Ligand-Linker Conjugate 1 is a conjugate of the MAGL ligand and the linker. MAGL Ligand-Linker Conjugate 1 can be used for synthesis of PROTAC degrader PROTAC MAGL degrader-1 (HY-173369) .

HY-172593

E3 Ligase Ligand-linker Conjugate 182	E3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-linker Conjugate 182 is a E3 Ligase Ligand-Linker Conjugates. E3 Ligase Ligand-linker Conjugate 182 consists of a CRBN ligand and a **PROTAC linker*. E3 Ligase Ligand-linker* Conjugate 182 can be used to design *PROTACs* (such as LZ-07 (HY-172590)) .

HY-176872

SMARCA2 Ligand-Linker Conjugate-4	Target Protein Ligand-Linker Conjugates SWI/SNF Complex	Cancer
SMARCA2 Ligand-Linker Conjugate-4 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for SMARCA2 (HY-178414) and a PROTAC linker, which recruits E3 ligases. SMARCA2 Ligand-Linker Conjugate-4 can be used for synthesis of PROTAC SMARCA2 degrader-35 (HY-176871) .

HY-139655

cIAP1 Ligand-Linker Conjugates 16	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 16 is an E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs.

HY-175457

AR-DBD ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates Androgen Receptor	Cancer
AR-DBD ligand-Linker Conjugate 1 is a conjugate of AR-DBD ligand and linker. AR-DBD ligand-Linker Conjugate 1 can be used to synthesize *PROTAC* LYA914 (HY-175455) .

HY-176387

E3 Ligase Ligand-linker Conjugate 201	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 201 is a synthesized E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs, such as PROTAC ER Degrader-3 (HY-128527) .

HY-173415

E3 Ligase Ligand-linker Conjugate 177	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 177 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 177 can be used to synthesize STING PROTAC degrader ST9 .

HY-175268

PXR ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates Pregnane X Receptor (PXR)	Metabolic Disease
PXR ligand-Linker Conjugate 1 is a conjugate of PXR ligand and linker, which can be used to synthesize PROTAC MI1013 (HY-175266) .

HY-175337

c-Met ligand-Linker Conjugate 2	Target Protein Ligand-Linker Conjugates c-Met/HGFR	Cancer
c-Met ligand-Linker Conjugate 2 is a synthesized target protein ligand-linker conjugate that can be used for synthesis of PROTACs, such as PROTAC c-Met degrader-6 (HY-175321). PROTAC c-Met degrader-6 is a c-Met PROTAC degrader with anti-tumor activity ^{[1] ^.}

HY-173470

MTP3 Ligand-linker Conjugate 1	E3 Ligase Ligand-Linker Conjugates	Cancer
MTP3 Ligand-linker Conjugate 1 is a conjugate of the MTP3 ligand and the linker. MTP3 Ligand-linker Conjugate 1 can be used for synthesis of PROTAC MTP3 degrade-1 (HY-173467) .

HY-174796

E3 Ligase Ligand-linker Conjugate 195	E3 Ligase Ligand-Linker Conjugates	Inflammation/Immunology
E3 Ligase Ligand-linker Conjugate 195 is a conjugate of the CRBN ligand (HY-174470) and the linker. E3 Ligase Ligand-linker Conjugate 195 can be used for synthesis of PROTACs such as APH02174 (HY-174455) .

HY-176425

E3 Ligase Ligand-linker Conjugate 186	E3 Ligase Ligand-Linker Conjugates	Inflammation/Immunology
E3 Ligase Ligand-linker Conjugate 186 is a CRBN E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 186 can be used to synthesize PROTAC SJ10542 (HY-145696) .

HY-162201

E3 Ligase Ligand-linker Conjugate 48	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 48 is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

HY-162188

E3 Ligase Ligand-linker Conjugate 15	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 15 is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

HY-157589

E3 ligase Ligand-Linker Conjugate 31	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 31 is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

HY-175528

ALK ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates Anaplastic lymphoma kinase (ALK)	Cancer
ALK ligand-Linker Conjugate 1 is a ALK ligand-linker conjugate that can be used for synthesis of PROTAC ALK degrader-4 (HY-175527) .

HY-172949

E3 Ligase Ligand-linker Conjugate 187	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 187 is a CRBN E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 187 can be used to synthesize PROTAC SD-2301 (HY-172946) .

HY-128822

cIAP1 Ligand-Linker Conjugates 13 E3 ligase Ligand-linker conjugates 43	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 13 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 13 can be used to design SNIPERs .

HY-128813A

cIAP1 Ligand-Linker Conjugates 15 hydrochloride E3 ligase Ligand-linker conjugates 34 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 15 hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 15 hydrochloride can be used to design SNIPERs .

HY-128815

cIAP1 Ligand-Linker Conjugates 14 E3 ligase Ligand-linker conjugates 36	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 14 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 14 can be used to design SNIPERs .

HY-128816A

cIAP1 Ligand-Linker Conjugates 2 (Hydrochloride) E3 ligase Ligand-linker conjugates 37 (Hydrochloride)	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 2 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 2 Hydrochloride can be used to design SNIPERs .

HY-128820

cIAP1 Ligand-Linker Conjugates 1 E3 ligase Ligand-linker conjugates 41	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 1 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 1 can be used to design SNIPERs .

HY-128819

cIAP1 Ligand-Linker Conjugates 3 E3 ligase Ligand-linker conjugates 40	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 3 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 3 can be used to design SNIPERs .

HY-128826

cIAP1 Ligand-Linker Conjugates 10 E3 ligase Ligand-linker conjugates 47	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 10 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 10 can be used to design SNIPERs .

HY-128812A

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride E3 ligase Ligand-linker conjugates 33 Hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 Hydrochloride can be used to design SNIPERs .

Cat. No.	Product Name	Type

HY-141658

Pomalidomide-PEG6-C2-COOH Pomalidomide-PEG6-COOH	Biochemical Assay Reagents
Pomalidomide-PEG6-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide (HY-10984) based cereblon ligand and 6-unit PEG linker used in PROTAC technology .

HY-174925

Thalidomide-O-PEG3-COOH	Biochemical Assay Reagents
Thalidomide-O-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .

Cat. No.	Product Name		Classification

HY-140213

Azido-PEG2-C2-amine N3-PEG2-CH2CH2NH2		PROTAC Synthesis ADC Synthesis Azide
Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based **PROTAC linker** that can be used in the synthesis of PROTACs . Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG2-C2-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130435

DBCO-PEG4-amine		ADC Synthesis DBCO PROTAC Synthesis
DBCO-PEG4-amine is a PEG-based **PROTAC linker** can be used in the synthesis of PROTACs. DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker) . DBCO-PEG4-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-140454

Azido-PEG8-acid		ADC Synthesis Azide PROTAC Synthesis
Azido-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG8-acid is also a PEG-based **PROTAC linker** that can be used in the synthesis of PROTACs . Azido-PEG8-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140215

Azido-PEG6-amine		Azide ADC Synthesis PROTAC Synthesis
Azido-PEG6-amine is a PEG-based **PROTAC linker** that can be used in the synthesis of PROTACs . Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG6-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130184

Azido-PEG8-NHS ester		ADC Synthesis PROTAC Synthesis Azide
Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based **PROTAC linker** that can be used in the synthesis of PROTACs . Azido-PEG8-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140150

Azido-PEG3-Val-Cit-PAB-PNP		Azide ADC Synthesis PROTAC Synthesis
Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based **PROTAC linker** that can be used in the synthesis of PROTACs . Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130653

Azido-PEG4-C2-acid		PROTAC Synthesis Azide ADC Synthesis
Azido-PEG4-C2-acid a PEG-based *PROTAC* linker can be used in the synthesis of vRucaparib-TP4. Azido-PEG4-C2-acid is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-126885

DBCO-PEG5-NHS ester 1 Publications Verification		DBCO PROTAC Synthesis ADC Synthesis
DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based **PROTAC linker** can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-W051634

Propargyl-PEG2-amine		ADC Synthesis Alkynes PROTAC Synthesis
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based **PROTAC linker** can be used in the synthesis of PROTACs . Propargyl-PEG2-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101157

Propargyl-PEG5-acid		ADC Synthesis PROTAC Synthesis Alkynes
Propargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG5-acid is a PEG-based **PROTAC linker** that can be used in the synthesis of PROTACs . Propargyl-PEG5-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130211

Azido-PEG5-alcohol		PROTAC Synthesis Azide ADC Synthesis
Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG5-alcohol is also a PEG-based **PROTAC linker** that can be used in the synthesis of PROTACs . Azido-PEG5-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-133736

PROTAC BRD4 Degrader-5-CO-PEG3-N3		PROTAC Synthesis Azide
PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader (MZ 1 (HY-107425) analog) and PEG-based linker. PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTAC BRD4 Degrader-5-CO-PEG3-N3 can be used for the research of HER2-positive breast cancer .

HY-126974

Propargyl-PEG3-NHS ester		PROTAC Synthesis ADC Synthesis Alkynes
Propargyl-PEG3-NHS ester is a PEG/Alkyl/ether-based **PROTAC linker** can be used in the synthesis of PROTACs. Propargyl-PEG3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG3-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130388

Propargyl-PEG5-NHS ester		Alkynes ADC Synthesis PROTAC Synthesis
Propargyl-PEG5-NHS ester is a PEG/Alkyl/ether-based **PROTAC linker** can be used in the synthesis of PROTACs. Propargyl-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG5-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-140004

Azide-PEG3-Tos		PROTAC Synthesis Azide ADC Synthesis
Azide-PEG3-Tos is a PEG-based **PROTAC linker** that can be used in the synthesis of PROTACs . Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103601

(S,R,S)-AHPC-PEG4-N3 1 Publications Verification VH032-PEG4-N3; VHL Ligand-linker conjugates 5; E3 ligase Ligand-linker conjugates 4		Azide
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in *PROTAC* technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-174995

JQ-1-Azidopropylamine		Azide
JQ-1-Azidopropylamine is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-151862), which recruits E3 ligases. JQ-1-Azidopropylamine can be used for synthesis of PROTAC JY-21 (HY-174975) .

HY-130346

DBCO-PEG4-DBCO		ADC Synthesis PROTAC Synthesis DBCO
DBCO-PEG4-DBCO is a PEG-based **PROTAC linker** can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-130572

Azido-PEG5-acid		Azide ADC Synthesis PROTAC Synthesis
Azido-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs, such as the conjugate CPT-APO (CPT: Camptothecin (HY-16560)). Azido-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG5-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130324

Azido-PEG7-amine		ADC Synthesis PROTAC Synthesis Azide
Azido-PEG7-amine is a non-cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG7-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG7-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130474

Azido-PEG6-NHS ester		Azide PROTAC Synthesis ADC Synthesis
Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based **PROTAC linker** that can be used in the synthesis of PROTACs . Azido-PEG6-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130537

Azido-PEG6-alcohol		ADC Synthesis PROTAC Synthesis Azide
Azido-PEG6-alcohol is a PEG-based **PROTAC linker** that can be used in the synthesis of PROTACs . Azido-PEG6-alcohol is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG6-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130485

Bromo-PEG2-C2-azide		PROTAC Synthesis Azide ADC Synthesis
Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Bromo-PEG2-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103598

(S,R,S)-AHPC-PEG3-N3 VH032-PEG3-N3; VHL Ligand-linker conjugates 8; E3 ligase Ligand-linker conjugates 12		Azide
(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in *PROTAC* technology. (S,R,S)-AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103600

(S,R,S)-AHPC-PEG1-N3 VH032-PEG1-N3; VHL Ligand-linker conjugates 9; E3 ligase Ligand-linker conjugates 3		Azide
(S,R,S)-AHPC-PEG1-N3 (VH032-PEG1-N3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in *PROTAC* technology. (S,R,S)-AHPC-PEG1-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-125843

Pomalidomide-PEG1-C2-N3 Cereblon Ligand-linker conjugates 13; E3 ligase Ligand-linker conjugates 50		Azide PROTAC Synthesis
Pomalidomide-PEG1-C2-N3 (Cereblon Ligand-Linker Conjugates 13) is a cereblon E3 ligand-linker conjugate that can be used to synthesisi selective CDK6 PROTAC degrader CP-10 (HY-125835). Pomalidomide-PEG1-C2-N3 can be used for the research of cancers .

HY-130379

Propargyl-PEG8-acid		PROTAC Synthesis ADC Synthesis Alkynes
Propargyl-PEG8-acid is a PEG-based **PROTAC linker** can be used in the synthesis of PROTACs. Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria . Propargyl-PEG8-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141015

Pomalidomide-PEG4-azide		Azide
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130144

Ald-CH2-PEG3-azide		PROTAC Synthesis Azide ADC Synthesis
Ald-CH2-PEG3-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ald-CH2-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Ald-CH2-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-133139

Lenalidomide-PEG1-azide		PROTAC Synthesis Azide
Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2 (HY-133136) . Lenalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-128832

Nutlin-C1-amido-PEG4-C2-N3 MDM2 Ligand-linker conjugates 1; E3 ligase Ligand-linker conjugates 48		Azide
Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in *PROTAC* technology. Nutlin-C1-amido-PEG4-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-141170

TCO-PEG12-NHS ester		TCO ADC Synthesis PROTAC Synthesis
TCO-PEG12-NHS ester is a PEG-based **PROTAC linker** can be used in the synthesis of PROTACs. TCO-PEG12-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-130591

Propargyl-PEG4-Br		PROTAC Synthesis ADC Synthesis Alkynes
Propargyl-PEG4-Br is a PEG-based **PROTAC linker** can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-126976

Propargyl-PEG5-amine		Alkynes PROTAC Synthesis ADC Synthesis
Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based **PROTAC linker** can be used in the synthesis of PROTACs . Propargyl-PEG5-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-118764

Propargyl-PEG2-acid		PROTAC Synthesis Alkynes ADC Synthesis
Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-acid is also a PEG-based **PROTAC linker** that can be used in the synthesis of PROTACs . Propargyl-PEG2-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133138

Pomalidomide-PEG1-azide		Azide PROTAC Synthesis
Pomalidomide-PEG1-azide is an E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-PEG1-azide can be used to synthesis PROTAC BRD4 Degrader-1 (HY-133131) . PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC₅₀ of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression.

HY-128767

VH032-PEG3-acetylene		Alkynes
VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in *PROTAC* technology . VH032-PEG3-acetylene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130169

Azido-PEG9-amine		PROTAC Synthesis Azide ADC Synthesis
Azido-PEG9-amine is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG9-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG9-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-113931

Aminooxy-PEG2-azide		PROTAC Synthesis ADC Synthesis Azide
Aminooxy-PEG2-azide is a PEG-based **PROTAC linker** that can be used in the synthesis of PROTACs . Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-126949

Aminooxy-PEG3-azide		Azide ADC Synthesis PROTAC Synthesis
Aminooxy-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Aminooxy-C2-PEG3-azide is also a PEG-based **PROTAC linker** that can be used in the synthesis of PROTACs . Aminooxy-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140844

Thalidomide-O-PEG4-azide		Azide
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-137538

Pomalidomide-PEG3-azide		Azide
Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology . Pomalidomide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-42618

Azido-PEG4-CH2-Boc		PROTAC Synthesis Azide ADC Synthesis
Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based **PROTAC linker** that can be used in the synthesis of PROTACs . Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-124386

DBCO-NHCO-PEG4-amine		DBCO
DBCO-NHCO-PEG4-amine is a PEG-based **PROTAC linker** can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC₅₀s of 280 nM and 22 nM in SKBR3 cells, respectively) .

HY-118808

Propargyl-PEG2-NHBoc		Alkynes ADC Synthesis PROTAC Synthesis
Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based **PROTAC linker** can be used in the synthesis of PROTACs . Propargyl-PEG2-NHBoc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130385

Propargyl-PEG6-NHS ester		PROTAC Synthesis Alkynes ADC Synthesis
Propargyl-PEG6-NHS ester is a PEG/Alkyl/ether-based **PROTAC linker** can be used in the synthesis of PROTACs. Propargyl-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG6-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130376

Propargyl-PEG8-NHS ester		Alkynes PROTAC Synthesis ADC Synthesis
Propargyl-PEG8-NHS ester is a PEG/Alkyl/ether-based **PROTAC linker** can be used in the synthesis of PROTACs. Propargyl-PEG8-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG8-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-103599

(S,R,S)-AHPC-PEG2-N3 1 Publications Verification VH032-PEG2-N3; VHL Ligand-linker conjugates 6; E3 ligase Ligand-linker conjugates 13		Azide
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-N3 can be used for the synthesis of *PROTACs* .

HY-130182

Propargyl-PEG8-NH2		ADC Synthesis PROTAC Synthesis Alkynes
Propargyl-PEG8-NH2 (compound 3b) is a PEG-based **PROTAC linker** can be used in the synthesis of PROTACs. Propargyl-PEG8-NH2 is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG8-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-132208

Pomalidomide 4'-PEG2-azide		Azide
Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide 4'-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-174863

Pomalidomide-C2-PEG-NHCO-C2-COOH		Pegylated Lipids
Pomalidomide-C2-PEG-NHCO-C2-COOH is a conjugate of the CRBN ligand (HY-10984) and the linker (E3 Ligase Ligand-Linker Conjugate). Pomalidomide-C2-PEG-NHCO-C2-COOH can be used for synthesizing PROTAC ASK1 degrader dASK1 (HY-174862) .

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