PROTAC BRD4 Degrader-43
PROTAC BRD4 Degrader-43 is a BRD4 PROTAC degrader. PROTAC BRD4 Degrader-43 recruits the DCAF1-DDB1-Cul4A E3 ligase complex via a Vpr-derived peptide moiety to induce BRD4 ubiquitination and degradation through the ubiquitin-proteasome system. PROTAC BRD4 Degrader-43 exhibits potent HIV latency-reversing activity. PROTAC BRD4 Degrader-43 can be used for the research of HIV-1 latent infection. (Pink: BRD4 ligand (HY-13030); Blue: Cul4A-DDB1-DCAF1 ligand (HY-P11640); Black: conjugate of PEG linker + cell-penetrating peptide (HY-P2483))
For research use only. We do not sell to patients.
- Formula: C151H251ClN60O41S2
- Molecular Weight:3662.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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BRD4 |
PROTAC BRD4 Degrader-43 (Compound 11) (1-30 μM) degrades BRD4 in MCF-7 cells[1].
PROTAC BRD4 Degrader-43 has low cytotoxicity in MCF-7, J-Lat 10.6, and THP-1 NLuc#225 cells, with CC50 values ≥45 μM[1].
PROTAC BRD4 Degrader-43 (20-50 μM) exhibits potent HIV latency-reversing activity in J-Lat 10.6 and THP-1 NLuc#225 cells, with stronger activity in THP-1 NLuc#225 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 3662.57
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Formula C151H251ClN60O41S2
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SMILES
O=C([C@@H](NC(COCCOCCN[C@@H](CCCCNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(COCCOCCOCCNC(C[C@H]1C2=NN=C(N2C3=C(C(C4=CC=C(C=C4)Cl)=N1)C(C)=C(S3)C)C)=O)=O)=O)CCSC)N[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N6[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N7[C@H](C(N)=O)CCC7)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCC6)=O)=O)CCC(N)=O)=O)CC(O)=O)=O)CCC(O)=O)=O)CCC5)=O)C)=O)CCC(N)=O)=O)CCC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC BRD4 Degrader-43 Related Classifications
HY-181164 Related Classifications
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