PROTAC BRD4 Degrader-43 

PROTAC BRD4 Degrader-43 is a BRD4 PROTAC degrader. PROTAC BRD4 Degrader-43 recruits the DCAF1-DDB1-Cul4A E3 ligase complex via a Vpr-derived peptide moiety to induce BRD4 ubiquitination and degradation through the ubiquitin-proteasome system. PROTAC BRD4 Degrader-43 exhibits potent HIV latency-reversing activity. PROTAC BRD4 Degrader-43 can be used for the research of HIV-1 latent infection^[1]. (Pink: BRD4 ligand (HY-13030); Blue: Cul4A-DDB1-DCAF1 ligand (HY-P11640); Black: conjugate of PEG linker + cell-penetrating peptide (HY-P2483))

PROTAC BRD4 Degrader-43 (Compound 11) (1-30 μM) degrades BRD4 in MCF-7 cells^[1].
PROTAC BRD4 Degrader-43 has low cytotoxicity in MCF-7, J-Lat 10.6, and THP-1 NLuc#225 cells, with CC₅₀ values ≥45 μM^[1].
PROTAC BRD4 Degrader-43 (20-50 μM) exhibits potent HIV latency-reversing activity in J-Lat 10.6 and THP-1 NLuc#225 cells, with stronger activity in THP-1 NLuc#225 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3662.57

C₁₅₁H₂₅₁ClN₆₀O₄₁S₂

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tsuji K, et al. Application of HIV-1 viral protein R-derived-peptides as new E3 ligase-binding components of BRD4 degraders. RSC Chem Biol. 2025;7(1):136-143. Published 2025 Oct 29.  [Content Brief]