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Cat. No.: HY-181918

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PLM-101-C3-NHBoc

PLM-101-C3-NHBoc is a conjugate of a RET-targeting ligand and a linker, which can be used in the synthesis of PROTAC RET Degrader 2 (HY-181895).

For research use only. We do not sell to patients.

Formula: C₃₀H₃₇FN₆O₄
Molecular Weight:564.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PLM-101-C3-NHBoc Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PLM-101-C3-NHBoc is a conjugate of a RET-targeting ligand and a linker, which can be used in the synthesis of PROTAC RET Degrader 2 (HY-181895)^[1].

Chemical Information

Molecular Weight 564.65
Formula C₃₀H₃₇FN₆O₄
SMILES

FC1=CC(/C2=C3\C(C4=C(C=CC=C4)N3)=N\OCCN(CC5)CCN5CCCNC(OC(C)(C)C)=O)=C(C=C1)NC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu N, et al. Design, synthesis, and activity evaluation of RET protein degradation based on PROTAC and HyTTD techniques. Bioorg Med Chem Lett. 2026;135:130588. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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