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Cat. No.: HY-177927

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CBP-IN-1 acid

CBP-IN-1 acid is a CBP Inhibitor-Linker Conjugate composed of CBP-IN-1 (HY-153948) and a linker. CBP-IN-1 acid can be used to synthesize PROTACs, such as CBPD-268 (HY-161369).

For research use only. We do not sell to patients.

CAS No.: 2750072-14-9
Formula: C₂₉H₃₅F₂N₇O₃
Molecular Weight:567.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

CBP-IN-1 acid Chemical Structure

CAS No.: 2750072-14-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

CBP-IN-1 acid is a CBP Inhibitor-Linker Conjugate composed of CBP-IN-1 (HY-153948) and a linker. CBP-IN-1 acid can be used to synthesize PROTACs, such as CBPD-268 (HY-161369)^[1].

All Epigenetic Reader Domain Isoforms :

All Histone Acetyltransferase Isoforms :

In Vitro

CBP-IN-1 acid (Compound 48) can be used for the synthesis of CBPD-268 (HY-161369)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2750072-14-9
Molecular Weight 567.63
Formula C₂₉H₃₅F₂N₇O₃
SMILES

O=C(CN1CCC(CC1)N2N=C(N3C4=C(CCC3)C=C(C5=CN(C)N=C5)C(C(F)F)=C4)C6=C2CCN(C6)C(C)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen Z, et al. Discovery of CBPD-268 as an Exceptionally Potent and Orally Efficacious CBP/p300 PROTAC Degrader Capable of Achieving Tumor Regression. J Med Chem. 2024;67(7):5275-5304. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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CBP-IN-1 acid

All Epigenetic Reader Domain Isoforms

All Histone Acetyltransferase Isoforms