Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C-boc
Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
For research use only. We do not sell to patients.
- Formula: C31H41N5O6
- Molecular Weight:579.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C-boc Chemical Structure](https://file.medchemexpress.com/product_pic/hy-161196.gif "Click to View Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C-boc Chemical Structure")
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Cereblon (CRBN)[1]
Chemical Information
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Molecular Weight 579.69
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Formula C31H41N5O6
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SMILES
O=C1NC(CCC1N2C(C3=C(C=CC(N4CC5(CN(C5)CC6CCN(CC6)CC(OC(C)(C)C)=O)CC4)=C3)C2=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [Content Brief]
[2]. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203. [Content Brief]
[3]. Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C-boc Related Classifications
HY-161196 Related Classifications
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