2. PROTAC Autophagy
  3. Ligands for E3 Ligase Autophagy
  4. Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OH

Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OH 

Cat. No.: HY-161197
Handling Instructions Technical Support

Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OH

Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OH 화학구조

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Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OH Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

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제품 설명

Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

IC50 & Target

Cereblon (CRBN)[1]
분자량

553.65

화학식

C29H39N5O6
SMILES

O=C1NC(CCC1N2C(C3=C(C=CC(N4CC5(CN(CC5)CC6CCN(CC6)CCOCCO)C4)=C3)C2=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OH Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OHLigands for E3 LigaseAutophagyE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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상품명:
Thalidomide-2,6-diazaspiro[3.4]octane-C-piperidine-C2-O-C2-OH
Cat. No.:
HY-161197
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