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Cat. No.: HY-161773

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HL389-NHC2-PEG3-C2NH

HL389-NHC2-PEG3-C2NH inhibits proliferation of cancer cells MDA-MB-231 and MCF-7, with IC₅₀ of 11.39 μM and 9.66 μM. HL389-NHC2-PEG3-C2NH can be utilized as a conjugate of an E3 ligase ligand and a linker, for the synthesis of PROTAC degrader HL435 (HY-161769).

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Formule: C₂₈H₃₃BrF₃N₃O₆
Masse moléculaire:644.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

HL389-NHC2-PEG3-C2NH Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

Voir tous les produits spécifiques à Isoform E3 Ligase Ligand-Linker Conjugates :

Chemical Information

Masse moléculaire 644.48
Formule C₂₈H₃₃BrF₃N₃O₆
SMILES

NCCCOCCOCCOCCCNC(COC1=C(/C=C(C(C=CC(C(F)(F)F)=C2)=C2N3)\C3=O)C=C(Br)C=C1)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang Y, et al., Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation. PLoS Biol. 2024 May 20;22(5):e3002550. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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HL389-NHC2-PEG3-C2NH

Voir tous les produits spécifiques à Isoform E3 Ligase Ligand-Linker Conjugates

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

HL389-NHC2-PEG3-C2NH Related Classifications

HY-161773 Related Classifications