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Cat. No.: HY-137340

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WH-10417-099

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WH-10417-099 is a CRBN-based PROTAC multi-kinase degrader that induces the degradation of the maximum number of unique kinases (over 125 unique kinases, such as CSNK1E and PI3Kγ) simultaneously. WH-10417-099 induces protein degradation via the ubiquitin biotinylation (E-STUB) pathway, exhibits synergistic effects with SB-405483 (HY-W1135319). The E3 ligase ligand and linker of WH-10417-099 can form the conjugate Pomalidomide 4'-PEG5-acid (HY-131647).
(Pink: PI3Kγ ligand (HY-168319); Blue: Cereblon ligand (HY-41547); Black: linker (HY-115384)).

For research use only. We do not sell to patients.

Purity: 98.14%
CAS No.: 2769753-42-4
Formula: C₅₂H₆₂N₈O₁₃S
Molecular Weight:1039.16

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

WH-10417-099 Chemical Structure

CAS No.: 2769753-42-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

WH-10417-099 is a CRBN-based PROTAC multi-kinase degrader that induces the degradation of the maximum number of unique kinases (over 125 unique kinases, such as CSNK1E and PI3Kγ) simultaneously. WH-10417-099 induces protein degradation via the ubiquitin biotinylation (E-STUB) pathway, exhibits synergistic effects with SB-405483 (HY-W1135319). The E3 ligase ligand and linker of WH-10417-099 can form the conjugate Pomalidomide 4'-PEG5-acid (HY-131647)^[1]^[2]. (Pink: PI3Kγ ligand (HY-168319); Blue: Cereblon ligand (HY-41547); Black: linker (HY-115384)).

IC₅₀ & Target^[1]

Cereblon

CK1

All PROTACs Isoforms :

All Casein Kinase Isoforms :

In Vitro

WH-10417-099 (1 μM; 1 hour) induces significant bio-ubiquitylation of 8 kinases (STK4, STK35, GSPT1, RIPK2, MAP4K4, STK3, CSNK1D, CSNK1A1) and 1 non-kinase (CSNK1E) in 293TCRBN^−/− cells expressing CRBN-BirA and A3-ubiquitin, with only CSNK1E undergoing significant degradation^[1].
WH-10417-099 (100 nM; 24 h) treatment of HEK293T cells drives significant downregulation of ¹⁴ proteins, including nine kinases, and co-treatment with 10 µM SB-405483 refines this subset of downregulated proteins to a stringent group of shared targets^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2769753-42-4
Appearance Solid
Molecular Weight 1039.16
Formula C₅₂H₆₂N₈O₁₃S
Color Light yellow to yellow
SMILES

O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOCCOCCC(NCCCN(C4CC4)S(C5=CC=C(C6=CN=C(N)C(C7=CC(CCNC8=O)=C8C=C7)=C6)C=C5)(=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 40 mg/mL (38.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.9623 mL

4.8116 mL

9.6232 mL

5 mM

0.1925 mL

0.9623 mL

1.9246 mL

10 mM

0.0962 mL

0.4812 mL

0.9623 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang H T, et al. Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates[J]. Nature Chemical Biology, 2024, 20(9): 1227-1236.

[2]. Dippon VN, et al. Identification of an allosteric site on the E3 ligase adapter cereblon. Nature. 2026;651(8105):482-490. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.9623 mL	4.8116 mL	9.6232 mL	24.0579 mL
	5 mM	0.1925 mL	0.9623 mL	1.9246 mL	4.8116 mL
	10 mM	0.0962 mL	0.4812 mL	0.9623 mL	2.4058 mL
	15 mM	0.0642 mL	0.3208 mL	0.6415 mL	1.6039 mL
	20 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2029 mL
	25 mM	0.0385 mL	0.1925 mL	0.3849 mL	0.9623 mL
	30 mM	0.0321 mL	0.1604 mL	0.3208 mL	0.8019 mL

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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WH-10417-099

Cell Cycle/DNA Damage Compound Library

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

PROTAC Library

Multi-Target Compound Library

Bioactive Compound Library Max

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

All PROTACs Isoforms

All Casein Kinase Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

WH-10417-099

Cell Cycle/DNA Damage Compound Library

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

PROTAC Library

Multi-Target Compound Library

Bioactive Compound Library Max

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

All PROTACs Isoforms

All Casein Kinase Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

WH-10417-099 Related Classifications

Cat. No.: HY-137340