2769753-42-4
Chemical Structure
WH-10417-099
- CAS No.: 2769753-42-4
- Formula:C52H62N8O13S
- Molecular Weight:1039.16
IUPAC Name: N-(3-((4-(6-amino-5-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)pyridin-3-yl)-N-cyclopropylphenyl)sulfonamido)propyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaoctadecan-18-amide
InChIKey: FBFSEQRYZRBYLH-UHFFFAOYSA-N
SMILES: O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOCCOCCC(NCCCN(C4CC4)S(C5=CC=C(C6=CN=C(N)C(C7=CC(CCNC8=O)=C8C=C7)=C6)C=C5)(=O)=O)=O)=O
Biological Activity: WH-10417-099 is a CRBN-based PROTAC multi-kinase degrader that induces the degradation of the maximum number of unique kinases (over 125 unique kinases, such as CSNK1E and PI3Kγ) simultaneously. WH-10417-099 induces protein degradation via the ubiquitin biotinylation (E-STUB) pathway, exhibits synergistic effects with SB-405483 (HY-W1135319). The E3 ligase ligand and linker of WH-10417-099 can form the conjugate Pomalidomide 4'-PEG5-acid (HY-131647)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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WH-10417-099 | 98.14% | WH-10417-099 is a CRBN-based PROTAC multi-kinase degrader that induces the degradation of the maximum number of unique kinases (over 125 unique kinases, such as CSNK1E and PI3Kγ) simultaneously. WH-10417-099 induces protein degradation via the ubiquitin biotinylation (E-STUB) pathway, exhibits synergistic effects with SB-405483 (HY-W1135319). The E3 ligase ligand and linker of WH-10417-099 can form the conjugate Pomalidomide 4'-PEG5-acid (HY-131647). | ||||||||||||||||||||
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References
- [1]. Huang H T, et al. Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates[J]. Nature Chemical Biology, 2024, 20(9): 1227-1236.
- [2]. Dippon VN, et al. Identification of an allosteric site on the E3 ligase adapter cereblon. Nature. 2026;651(8105):482-490. [Content Brief]
