DZ-837

Cat. No.: HY-161989 Purity: 95.48%: Data Sheet
COA

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Handling Instructions
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DZ-837 (compound 3d) is a PROTAC targeting BCL6 with a DC50 of approximately 600 nM. DZ-837 can induce cell cycle arrest and exert synergistic anticancer effects with Ibrutinib (HY-10997). DZ-837 is composed of PROTAC target protein ligand BCL6 ligand-2 (HY-161990) (red part), E3 ubiquitin ligase ligand Thalidomide-4-OH (HY-103596) (blue part), and PROTAC Linker (HY-W245803) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-hydroxyethoxy)ethyl)amino)isoindoline-1,3-dione (HY-W924949)^{[1]^.}

For research use only. We do not sell to patients.

DZ-837 Chemical Structure

CAS No. : 3105664-95-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

BCL6^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
DOHH-2	IC₅₀	56.2 nM Compound: 3d; DZ-837	Antiproliferative activity against BCL6-dependent human DOHH-2 cells assessed as inhibition in cell growth measured after 6 days by MTS assay Antiproliferative activity against BCL6-dependent human DOHH-2 cells assessed as inhibition in cell growth measured after 6 days by MTS assay	[PMID: 39208743]
HEK-293T	IC₅₀	> 10000 nM Compound: 3d; DZ-837	Cytotoxicity against HEK293T cells assessed as inhibition in cell growth measured after 6 days by MTT assay Cytotoxicity against HEK293T cells assessed as inhibition in cell growth measured after 6 days by MTT assay	[PMID: 39208743]
OCI-Ly1	IC₅₀	1370 nM Compound: 3d; DZ-837	Antiproliferative activity against BCL6-dependent human OCI-Ly1 cells assessed as inhibition in cell growth measured after 6 days by MTT assay Antiproliferative activity against BCL6-dependent human OCI-Ly1 cells assessed as inhibition in cell growth measured after 6 days by MTT assay	[PMID: 39208743]
SU-DHL-6	IC₅₀	450.9 nM Compound: 3d; DZ-837	Antiproliferative activity against BCL6-dependent human SU-DHL-6 cells assessed as inhibition in cell growth measured after 6 days by MTT assay Antiproliferative activity against BCL6-dependent human SU-DHL-6 cells assessed as inhibition in cell growth measured after 6 days by MTT assay	[PMID: 39208743]
SUD4	IC₅₀	399 nM Compound: 3d; DZ-837	Antiproliferative activity against BCL6-dependent human SU-DHL-4 cells assessed as inhibition in cell growth measured after 6 days by MTT assay Antiproliferative activity against BCL6-dependent human SU-DHL-4 cells assessed as inhibition in cell growth measured after 6 days by MTT assay	[PMID: 39208743]
WI-38 VA13	IC₅₀	> 10000 nM Compound: 3d; DZ-837	Cytotoxicity against human WI-38 VA13 cells assessed as inhibition in cell growth measured after 6 days by MTT assay Cytotoxicity against human WI-38 VA13 cells assessed as inhibition in cell growth measured after 6 days by MTT assay	[PMID: 39208743]

Molecular Weight

837.92

Formula

C₄₂H₄₄FN₉O₇S

CAS No.

3105664-95-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=C(C2=CCCC2)S1)NC3=CC=C(NC4=NC(N5CCN(CCOCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)CC5)=NC=C4F)C=C3OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (29.84 mM; ultrasonic and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1934 mL	5.9672 mL	11.9343 mL
5 mM	0.2387 mL	1.1934 mL	2.3869 mL
10 mM	0.1193 mL	0.5967 mL	1.1934 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.04%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (244 KB) HNMR (161 KB) RP-HPLC (174 KB) LCMS (390 KB)

Handling Instructions (2659 KB)

References

[1]. Mi D, et al. Discovery of novel BCL6-Targeting PROTACs with effective antitumor activities against DLBCL in vitro and in vivo. Eur J Med Chem. 2024 Nov 5;277:116789. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1934 mL	5.9672 mL	11.9343 mL	29.8358 mL
	5 mM	0.2387 mL	1.1934 mL	2.3869 mL	5.9672 mL
	10 mM	0.1193 mL	0.5967 mL	1.1934 mL	2.9836 mL
	15 mM	0.0796 mL	0.3978 mL	0.7956 mL	1.9891 mL
	20 mM	0.0597 mL	0.2984 mL	0.5967 mL	1.4918 mL
	25 mM	0.0477 mL	0.2387 mL	0.4774 mL	1.1934 mL

DZ-837 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DZ-8373105664-95-4DZ837DZ 837BCL6PROTACsB-cell lymphoma 6 proteinB-cell lymphoma 5 protein (BCL-5)Zinc finger and BTB domain-containing protein 27Zinc finger protein 51Inhibitorinhibitorinhibit

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DZ-837

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DZ-837 Related Antibodies

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Complete Stock Solution Preparation Table

DZ-837 Related Classifications

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