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Cat. No.: HY-183083

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CDK7 ligand 3-CO-C5-COOH

CDK7 ligand 3-CO-C5-COOH (compound 7) is a conjugate of CDK7 ligand and linker, which can be used for the synthesis of PROTAC TZ1104 (HY-183073).

For research use only. We do not sell to patients.

Formula: C₂₆H₃₆ClN₅O₅S
Molecular Weight:566.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK7 ligand 3-CO-C5-COOH Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

CDK7 ligand 3-CO-C5-COOH (compound 7) is a conjugate of CDK7 ligand and linker, which can be used for the synthesis of PROTAC TZ1104 (HY-183073)^[1].

IC₅₀ & Target^[1]

CDK7

All CDK Isoforms :

Chemical Information

Molecular Weight 566.11
Formula C₂₆H₃₆ClN₅O₅S
SMILES

O=C(N[C@H]1CC[C@H](NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(C(C)C)=O)=N2)CC1)CCCCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tu Y, et al. Discovery of a selective CDK7 PROTAC against acute leukemia with low platelet toxicity. Leukemia. Published online March 25, 2026. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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CDK7 ligand 3-CO-C5-COOH

All CDK Isoforms