Pomalidomide-PEG2-acetic acid
Based on 1 Customer Validation
Pomalidomide-PEG2-acetic acid (Pomalidomide-PEG2-CH2COOH) is a conjugate of CRBN ligand Pomalidomide (HY-10984) and a linker. Pomalidomide-PEG2-acetic acid can be used for PROTAC synthesis.
For research use only. We do not sell to patients.
- Purity: 99.43%
- CAS No.: 2143097-05-4
- Formula: C19H21N3O8
- Molecular Weight:419.39
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
The role of CRBN in the protein UPS degradation pathway is exerted when it binds to other proteins to form an E3 enzyme complex. In some cases, CRBN binds to Cullin-4A (CUL4A), Cullin regulatory protein 1 (ROC1), and damaged DNA-binding protein 1 (DDB1) to form an E3 ubiquitin ligase complex[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2143097-05-4
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Appearance Solid
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Molecular Weight 419.39
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Formula C19H21N3O8
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Color Light yellow to yellow
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SMILES
O=C(COCCOCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)O
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Synonyms
Pomalidomide-PEG2-CH2COOH
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (238.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3844 mL | 11.9221 mL | 23.8442 mL | 59.6104 mL |
| 5 mM | 0.4769 mL | 2.3844 mL | 4.7688 mL | 11.9221 mL | |
| 10 mM | 0.2384 mL | 1.1922 mL | 2.3844 mL | 5.9610 mL | |
| 15 mM | 0.1590 mL | 0.7948 mL | 1.5896 mL | 3.9740 mL | |
| 20 mM | 0.1192 mL | 0.5961 mL | 1.1922 mL | 2.9805 mL | |
| 25 mM | 0.0954 mL | 0.4769 mL | 0.9538 mL | 2.3844 mL | |
| 30 mM | 0.0795 mL | 0.3974 mL | 0.7948 mL | 1.9870 mL | |
| 40 mM | 0.0596 mL | 0.2981 mL | 0.5961 mL | 1.4903 mL | |
| 50 mM | 0.0477 mL | 0.2384 mL | 0.4769 mL | 1.1922 mL | |
| 60 mM | 0.0397 mL | 0.1987 mL | 0.3974 mL | 0.9935 mL | |
| 80 mM | 0.0298 mL | 0.1490 mL | 0.2981 mL | 0.7451 mL | |
| 100 mM | 0.0238 mL | 0.1192 mL | 0.2384 mL | 0.5961 mL |
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