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anti-cancer effects

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (649) Cardiovascular Disease (72) Endocrinology (14) Infection (141) Inflammation/Immunology (209) Metabolic Disease (73) Neurological Disease (140)
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Cat. No.	Nom du produit	Target	Áreas de investigación	Chemical Structure

HY-B0011

Docetaxel Maximum Cited Publications 158 Publications Verification RP-56976	Microtubule/Tubulin Apoptosis Endogenous Metabolite	Cancer
Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-10448

Capsaicin 80+ Cited Publications (E)-Capsaicin	Environmental Pollutants TRP Channel Autophagy Endogenous Metabolite Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects .

HY-13777

Zoledronic Acid 20+ Cited Publications Zoledronate; CGP 42446; CGP42446A; ZOL 446	Apoptosis Autophagy Bacterial	Metabolic Disease Cancer
Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

HY-N0820

Catalpol 10+ Cited Publications Catalpinoside	HBV	Infection Neurological Disease Inflammation/Immunology Cancer
Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0560

Oroxylin A 15+ Cited Publications Baicalein 6-methyl ether; 6-Methoxybaicalein	HIF/HIF Prolyl-Hydroxylase Autophagy Virus Protease	Cancer
Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis .

HY-N0372

Licochalcone A 15+ Cited Publications	Autophagy	Cancer
Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and K_i values lower than 5 μM) .

HY-N0105

Rhein 15+ Cited Publications Rheic Acid; Rhubarb yellow; Monorhein	Autophagy Reactive Oxygen Species (ROS) Bacterial Apoptosis	Infection Inflammation/Immunology Cancer
Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects ^{[1] ^.}

HY-N0013

Vitexin 10+ Cited Publications	Autophagy	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-13748

Silybin A 10+ Cited Publications Silibinin A	Autophagy Reactive Oxygen Species (ROS)	Cancer
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

HY-13667

Levoleucovorin Calcium 3 Publications Verification Calcium levofolinate; CL307782	Antifolate	Cancer
Levoleucovorin Calcium (Calcium levofolinate) is the active form of calcium Folinic acid (HY-13664) and has anti-tumor effects. Levoleucovorin Calcium is also a potentiator of the anti-cancer toxicity of 5-Fluorouracil (HY-90006) .

HY-N0664

Aucubin 5+ Cited Publications	Bacterial	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Aucubin is an iridoid glycoside component that acn be found in E. ulmoides. Aucubin can cross the blood-brain barrier (BBB) and has anti-anxiety, antidepressive and anti-neuroinflammatory effects. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .

HY-N0006

Demethoxycurcumin 5 Publications Verification Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin	Apoptosis Bacterial Cholinesterase (ChE) NO Synthase	Infection Neurological Disease Inflammation/Immunology Cancer
Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

HY-N0423

Sophoricoside 4 Publications Verification	Others	Inflammation/Immunology Cancer
Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.

HY-13777A

Zoledronic acid monohydrate 20+ Cited Publications Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate	Apoptosis Autophagy Bacterial	Metabolic Disease Cancer
Zoledronic acid monohydrate (Zoledronate monohydrate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic acid monohydrate inhibits the differentiation and apoptosis of osteoclasts. Zoledronic acid monohydrate also has anti-cancer effects .

HY-N0799

Protodioscin	Endogenous Metabolite	Cardiovascular Disease Cancer
Protodioscin, a major steroidal saponin in Trigonella foenum-graecum Linn., has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.

HY-10448R

Capsaicin (Standard) 80+ Cited Publications (E)-Capsaicin (Standard)	Reference Standards TRP Channel Autophagy Apoptosis Endogenous Metabolite	Cancer
Capsaicin (Standard) is the analytical standard of Capsaicin. This product is intended for research and analytical applications. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects .

HY-160699

DCC-3116 1 Publications Verification	ULK Ras Autophagy	Cancer
DCC-3116 is an orally active ULK1/2 inhibitor. DCC-3116 can inhibit autophagy in lung cancer cells by inhibiting KRAS ^G12C signaling, thereby inhibiting the proliferation of lung cancer cells and exerting anti-cancer effects .

HY-B0735A

Fenoldopam mesylate 4 Publications Verification Fenoldopam methanesulfonate; SKF-82526 mesylate	Dopamine Receptor Apoptosis	Cardiovascular Disease Cancer
Fenoldopam mesylate (SKF-82526) is a D₁ receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC₅₀=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis .

HY-16212

FR901464	Biochemical Assay Reagents	Cancer
FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects .

HY-100350

CA-074 methyl ester 35+ Cited Publications CA-074Me	Cathepsin	Neurological Disease Cancer
CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.

HY-B0114

Oxcarbazepine 2 Publications Verification GP 47680	Sodium Channel Apoptosis	Neurological Disease Cancer
Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Anti-cancer and anticonvulsant effects .

HY-N2510

Myristicin Myristicine	5-HT Receptor EGFR ERK Apoptosis Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc .

HY-N0401

Ligustilide	Autophagy Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Ligustilide is is a bioactive phthalide derivative isolated from Angelica sinensis and Chuanxiong. Ligustilide exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects .

HY-N1109

Uvaol 1 Publications Verification	Apoptosis	Inflammation/Immunology Cancer
Uvaol, a triterpene present in olives and virgin olive oil, possesses anti-inflammatory properties and antioxidant effects. Uvaol is an orally active inducer of apoptosis in astroglioma cells. Uvaol also has anti-cancer activities. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice .

HY-129566

Withanolide B	ERK Wnt β-catenin RUNX	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-N0362

Columbianadin 4 Publications Verification	Apoptosis	Inflammation/Immunology Cancer
Columbianadin, a natural coumarin from Heracleum hemsleyanum, is known to have various biological activities including anti-inflammatory and anti-cancer effects.

HY-106541

Neticonazole 1 Publications Verification	Fungal	Infection Cancer
Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects .

HY-W013573

S-Allyl-L-cysteine 1 Publications Verification	Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity.

HY-N2477

Taraxerol	Apoptosis NF-κB	Inflammation/Immunology Cancer
Taraxerol is isolated from Taraxacum mongolicum, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis .

HY-N6642

Ankaflavin	PPAR Apoptosis	Inflammation/Immunology Cancer
Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects .

HY-128365

Neticonazole hydrochloride 1 Publications Verification	Fungal	Infection Cancer
Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole hydrochloride has anti-infection and anti-cancer effects .

HY-N2521

Tetramethylcurcumin FLLL31	STAT Apoptosis	Inflammation/Immunology Cancer
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects .

HY-126940

Furanodiene	Reactive Oxygen Species (ROS) P-glycoprotein Apoptosis	Cancer
Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level .

HY-178872

Allyl thiosulfate Sodium 2-propenyl thiosulfate; 2PTS	COX	Inflammation/Immunology Cancer
Allyl thiosulfate (Sodium 2-propenyl thiosulfate) is found in Allium plants such as garlic and onion. Allyl thiosulfate can inhibit COX activity and reduce GSH concentration in platelets. Allyl thiosulfate exhibits anti-aggregatory and anti-cancer effects. Allyl thiosulfate can be used for the researches of cancer, inflammation and cardiovascular disease .

HY-19893

Antroquinonol (+)-Antroquinonol	Keap1-Nrf2	Inflammation/Immunology Cancer
Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata, has hepatoprotective, anti-inflammatory, and anti-cancer effects . Antroquinonol can be used for the research of colon cancer . Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice .

HY-145532

S-Allylmercaptocysteine	Apoptosis NF-κB Keap1-Nrf2	Inflammation/Immunology Cancer
S-allylmercaptocysteine, an organic sulfur compound extracted from garlic, has anti-inflammatory and anti-oxidative effects for various pulmonary diseases. S-allylmercaptocysteine achieves its anti-cancer effect through a variety of pathways such as inducing the apoptosis of cancer cells through the TGF-β signaling pathway, or reducing the NF-κB activity and up-regulating Nrf2 to achieve the effects of anti-inflammation and anti-oxidation .

HY-N2039

20(R)-Ginsenoside Rg2	Others	Cancer
20(R)-Ginsenoside Rg2 shows inhibitory effects on lung cancer NCI-H1650 cells. Anti-cancer activities .

HY-14374

GPP78 1 Publications Verification CAY10618	NAMPT Autophagy	Inflammation/Immunology Cancer
GPP78 (CAY10618) is a potent Nampt inhibitor with an IC₅₀ of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC₅₀ of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects .

HY-P10938

LP17 (human)	TREM receptor	Inflammation/Immunology Cancer
LP17 (human) is a TREM1 antagonist peptide with anti-inflammatory and anti-cancer effects .

HY-163939

RGT-018	SOS1 Ras	Cancer
RGT-018 is a potent and orally active SOS1 inhibitor with anti-tumor effects. RGT-018 exerts anti-cancer cell proliferation activity by inhibiting KRAS activation .

HY-N5086

Picroside IV	HBV	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820) . Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-134545

N-Arachidonoyl-L-alanine 2 Publications Verification NALA	Reactive Oxygen Species (ROS)	Cancer
N-Arachidonoyl-L-alanine is an endocannabinoid analog with *anti-cancer* effects. N- Arachidonoyl-L-alanine kills HNSCC cells through 5-LO-mediated ROS productio .

HY-N0006R

Demethoxycurcumin (Standard) Curcumin II (Standard); Desmethoxycurcumin (Standard); Monodemethoxycurcumin (Standard)	Reference Standards Apoptosis Bacterial Cholinesterase (ChE) NO Synthase	Infection Neurological Disease Inflammation/Immunology Cancer
Demethoxycurcumin (Standard) is the analytical standard of Demethoxycurcumin. This product is intended for research and analytical applications. Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

HY-W587738

Viridiflorol	Apoptosis	Cancer
Viridiflorol is an active natural molecule with anti-cancer effect. Viridiflorol induces anti-neoplastic effects on breast (MCF-7, IC₅₀ = 10 µM), lung (A549, IC₅₀ = 30 µM), and brain (Daoy, IC₅₀ = 0.1 µM) cancer cells through apoptosis. Viridiflorol can be used for breast, lung, and brain cancer research .

HY-103385

NCX4040 NO-Aspirin	Apoptosis	Inflammation/Immunology Cancer
NCX4040 (NO-Aspirin), a non-steroidal anti-inflammatory drug (NSAID), is a nitric oxide (NO) releasing form of Aspirin. NCX4040 induces apoptosis in PC3 metastatic prostate cancer cells. NCX4040 has anti-inflammatory and anti-cancer effects .

HY-N9451

Ginger extract	NF-κB	Cardiovascular Disease Inflammation/Immunology Cancer
Ginger extract exhibits anti-cancer, anti-inflammatory and chemotherapeutic effects in vivo .

HY-B0114R

Oxcarbazepine (Standard) GP 47680 (Standard)	Reference Standards Sodium Channel Apoptosis	Neurological Disease Cancer
Oxcarbazepine (Standard) is the analytical standard of Oxcarbazepine. This product is intended for research and analytical applications. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Anti-cancer and anticonvulsant effects .

HY-123952

RTC-5 TRC-382	EGFR	Cancer
RTC-5 (TRC-382) is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling .

HY-N0560R

Oroxylin A (Standard) Baicalein 6-methyl ether (Standard); 6-Methoxybaicalein (Standard)	Reference Standards HIF/HIF Prolyl-Hydroxylase Autophagy Virus Protease	Cancer
Oroxylin A (Standard) is the analytical standard of Oroxylin A. This product is intended for research and analytical applications. Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis .

HY-163811

BRD9 Degrader-4	Molecular Glues Epigenetic Reader Domain	Cancer
BRD9 Degrader-4 (BRD9c), a bifunctional molecular glue, is a potent BRD9 degrader with a DC₅₀ of ≤25 nM. BRD9 Degrader-4 has anti-cancer effects .

Cat. No.	Nom du produit	Category	Target	Chemical Structure

HY-B0011

Docetaxel Maximum Cited Publications 158 Publications Verification RP-56976	Structural Classification Classification of Application Fields Terpenoids Diterpenoids Endogenous metabolite Disease Research Fields Source Classification Cancer	Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-B0166

L-Ascorbic acid 75+ Cited Publications L-Ascorbate; Vitamin C	Structural Classification Productos naturales Neurological Disease Classification of Application Fields Moringa oleifera Lam. Endocrine diseases Metabolic Disease Plants Endogenous metabolite Disease markers Moringaceae Nervous System Disorder Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite Calcium Channel Reactive Oxygen Species (ROS) Apoptosis
L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-10448

Capsaicin 80+ Cited Publications (E)-Capsaicin	Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Phenols Solanaceae Plants Disease Research Fields Biological Pesticide Research Source Classification Cancer Agricultural Research	Environmental Pollutants TRP Channel Autophagy Endogenous Metabolite Apoptosis
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects .

HY-N0182

Fisetin 30+ Cited Publications	Flavonols Neurological Disease Classification of Application Fields Anti-aging Rosaceae Metabolic Disease Plants Flavonoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Fragaria × ananassa Duch. Source Classification Cancer	Sirtuin PPAR TNF Receptor
Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

HY-B0134

Bestatin 10+ Cited Publications Ubenimex	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Aminopeptidase Bacterial Antibiotic
Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-N0820

Catalpol 10+ Cited Publications Catalpinoside	Neurological Disease Classification of Application Fields Anti-aging Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Infection Iridoids Terpenoids Scrophulariaceae Inflammation/Immunology Disease Research Fields Source Classification Cancer	HBV
Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0560

Oroxylin A 15+ Cited Publications Baicalein 6-methyl ether; 6-Methoxybaicalein	Flavonoids Classification of Application Fields Flavones Phenols Polyphenols Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields Source Classification Cancer	HIF/HIF Prolyl-Hydroxylase Autophagy Virus Protease
Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis .

HY-N0372

Licochalcone A 15+ Cited Publications	Chalcones Flavonoids Classification of Application Fields Leguminosae Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification Cancer	Autophagy
Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and K_i values lower than 5 μM) .

HY-N0164

Matrine 15+ Cited Publications Matridin-15-one; Vegard; α-Matrine	Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Sophora flavescens Aiton Plants Inflammation/Immunology Disease Research Fields Biological Pesticide Research Source Classification Cancer Agricultural Research	PINK1/Parkin Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .

HY-N1584

Halofuginone 15+ Cited Publications RU-19110	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Dichroa febrifuga Lour Saxifragaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N0105

Rhein 15+ Cited Publications Rheic Acid; Rhubarb yellow; Monorhein	Infection Quinones Rheum palmatum L. Classification of Application Fields Anthraquinones Polygonaceae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Autophagy Reactive Oxygen Species (ROS) Bacterial Apoptosis
Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects ^{[1] ^.}

HY-N0013

Vitexin 10+ Cited Publications	Cardiovascular Disease Neurological Disease Classification of Application Fields Flavones Anti-aging Metabolic Disease Plants Flavonoids Leguminosae Phenols Polyphenols Trigonella foenum-graecum Linn. Disease Research Fields Source Classification Cancer	Autophagy
Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-13748

Silybin A 10+ Cited Publications Silibinin A	Flavanonols Flavonoids Glycine soya Classification of Application Fields Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Disease Research Fields Source Classification Cancer	Autophagy Reactive Oxygen Species (ROS)
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

HY-13667

Levoleucovorin Calcium 3 Publications Verification Calcium levofolinate; CL307782	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Antifolate
Levoleucovorin Calcium (Calcium levofolinate) is the active form of calcium Folinic acid (HY-13664) and has anti-tumor effects. Levoleucovorin Calcium is also a potentiator of the anti-cancer toxicity of 5-Fluorouracil (HY-90006) .

HY-N0664

Aucubin 5+ Cited Publications	Infection Structural Classification Eucommia ulmoides Oliver Iridoids Neurological Disease Classification of Application Fields Terpenoids Eucommiaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Bacterial
Aucubin is an iridoid glycoside component that acn be found in E. ulmoides. Aucubin can cross the blood-brain barrier (BBB) and has anti-anxiety, antidepressive and anti-neuroinflammatory effects. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .

HY-N0674

Dehydrocorydaline 40+ Cited Publications 13-Methylpalmatine	Infection Alkaloids Corydalis yanhusuo W. T. Wang Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0006

Demethoxycurcumin 5 Publications Verification Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin	Zingiber officinale Roscoe Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification Zingiberaceae Cancer	Apoptosis Bacterial Cholinesterase (ChE) NO Synthase
Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

HY-N1462

Atractyloside potassium salt 4 Publications Verification	Cardiovascular Disease Classification of Application Fields Terpenoids Pterocarpus soyauxii Taub. Diterpenoids Plants Compositae Disease Research Fields Source Classification	Chloride Channel Autophagy mTOR AMPK
Atractyloside potassium salt is a powerful and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart. Atractyloside potassium salt activates autophagy, inhibits ANT2, mTOR and promotes the activation of p-AMPK. Atractyloside potassium salt has anti-cancer effects on non-small cell lung cancer and can inhibit liver steatosis. Atractylodesin potassium salt has nephrotoxicity .

HY-N0423

Sophoricoside 4 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Sophora japonica (L.) Schott Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones Source Classification	Others
Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.

HY-N0799

Protodioscin	Classification of Application Fields Leguminosae Plants Endogenous metabolite Trigonella foenum-graecum Linn. Disease Research Fields Steroids Source Classification Cancer	Endogenous Metabolite
Protodioscin, a major steroidal saponin in Trigonella foenum-graecum Linn., has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.

HY-B0166R

L-Ascorbic acid (Standard) 2 Publications Verification L-Ascorbate (Standard); Vitamin C (Standard)	Structural Classification Productos naturales Microorganisms Moringa oleifera Lam. Disease markers Endocrine diseases Moringaceae Nervous System Disorder Plants Endogenous metabolite Source Classification	Reference Standards Reactive Oxygen Species (ROS) Calcium Channel Apoptosis Endogenous Metabolite
L-Ascorbic acid (Standard) is the analytical standard of L-Ascorbic acid. This product is intended for research and analytical applications. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-N0668

Rubusoside 2 Publications Verification	other families Classification of Application Fields Terpenoids Other Diseases Diterpenoids Plants Disease Research Fields Sweeteners Source Classification Food Research	GLUT Amylases NF-κB
Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits NF-κB and α-amylase (α-amylase) .

HY-N2389

Formosanin C 5 Publications Verification	Paris polyphylla Smith var. chinensis (Franch.) Hara Liliaceae Classification of Application Fields Plants Disease Research Fields Saccharides Cancer	Apoptosis Autophagy Ferroptosis NF-κB Fungal
Formosanin C is a diosgenin saponin with multiple biological activities. Formosanin C possesses multiple anti-tumor mechanisms, including inducing apoptosis and autophagy, blocking the cell cycle, inhibiting metastasis and inducing ferroptosis. Formosanin C can inhibit the NF-κB signaling pathway to exert anti-inflammatory effects, and enhance the activity of immune cells. Formosanin C exhibits the inhibiting effect against C. albicans. Formosanin C can be used for the study of anti-inflammation, antifungal anti and anti-cancer (including lung cancer, liver cancer, breast cancer and colorectal cancer, etc.) .

HY-10448R

Capsaicin (Standard) 80+ Cited Publications (E)-Capsaicin (Standard)	Structural Classification Capsicum annuum L. Classification of Application Fields Phenols Solanaceae Plants Disease Research Fields Biological Pesticide Research Source Classification Cancer Agricultural Research	Reference Standards TRP Channel Autophagy Apoptosis Endogenous Metabolite
Capsaicin (Standard) is the analytical standard of Capsaicin. This product is intended for research and analytical applications. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects .

HY-N1584A

Halofuginone hydrobromide 15+ Cited Publications RU-19110 hydrobromide	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Dichroa febrifuga Lour Saxifragaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-118620

Nortriptyline 3 Publications Verification Desmethylamitriptyline; Desitriptilina	Alkaloids Neurological Disease Classification of Application Fields Pterocarpus santalinus L. f. Other Alkaloids Labiatae Plants Disease Research Fields Cancer Source Classification	Autophagy Drug Metabolite Apoptosis
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects . N

HY-117371

Hemiasterlin (-)-Hemiasterlin; Milnamide B	Alkaloids Animals Classification of Application Fields Marine natural products Sponge Disease Research Fields Indole Alkaloids Cancer	ADC Payload
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .

HY-N4114

Picrocrocin	Classification of Application Fields Ketones, Aldehydes, Acids Lridaceae Plants Crocus sativus L. Disease Research Fields Source Classification Cancer	Apoptosis
Picrocrocin, an apocarotenoid found in Saffron. Picrocrocin shows anticancer effect. Picrocrocin exhibits growth inhibitory effects against SKMEL-2 human malignant melanoma cells .

HY-16212

FR901464	Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification Cancer	Biochemical Assay Reagents
FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects .

HY-119809

Violacein	Alkaloids Microorganisms Classification of Application Fields Sunscreen Cosmetic Research Disease Research Fields Indole Alkaloids Source Classification Cancer	Apoptosis Endogenous Metabolite
Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer .

HY-N2510

Myristicin Myristicine	Simple Phenylpropanols Myristicaceae Phenylpropanoids Plants Myristica fragrans Houtt. Source Classification	5-HT Receptor EGFR ERK Apoptosis Bacterial
Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc .

HY-N0401

Ligustilide	Cardiovascular Disease Productos naturales Neurological Disease Classification of Application Fields Dicerothamnus rhinocerotis Umbelliferae Plants Inflammation/Immunology Disease Research Fields Echinacea angustifolia DC. Source Classification	Autophagy Apoptosis
Ligustilide is is a bioactive phthalide derivative isolated from Angelica sinensis and Chuanxiong. Ligustilide exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects .

HY-N1109

Uvaol 1 Publications Verification	Triterpenes other families Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis
Uvaol, a triterpene present in olives and virgin olive oil, possesses anti-inflammatory properties and antioxidant effects. Uvaol is an orally active inducer of apoptosis in astroglioma cells. Uvaol also has anti-cancer activities. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice .

HY-129566

Withanolide B	Neurological Disease Classification of Application Fields Metabolic Disease Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	ERK Wnt β-catenin RUNX
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-W011641

(±)-Naringenin 4 Publications Verification	Cardiovascular Disease Flavonoids other families Classification of Application Fields Flavonones Phenols Polyphenols Plants Disease Research Fields Source Classification	Potassium Channel Toll-like Receptor (TLR) NF-κB Apoptosis Caspase
(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±)-Naringenin promotes vasodilation in endothelial cells by activating BK_Ca channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research .

HY-N0396

Harpagoside 4 Publications Verification	Iridoids Classification of Application Fields Terpenoids Pedaliaceae Plants Harpagophytum procumbens Inflammation/Immunology Disease Research Fields	COX NO Synthase
Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and COX-2 active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ).

HY-Y0790

Cuminaldehyde 1 Publications Verification p-Isopropylbenzaldehyde	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Rudbeckia laciniata L. Umbelliferae Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants α-synuclein
Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC₅₀= 0.00085 mg/mL), α-glucosidase (IC₅₀=0.5 mg/mL) and lipoxygenase (IC₅₀=1370 μM). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .

HY-108964

Carvone	Acourtia cordata (Cerv.) B.L.Turner Structural Classification Ketones, Aldehydes, Acids Umbelliferae Plants Source Classification	Bacterial
Carvone is a ketone monoterpene found in the essential oils from plants of the genus Mentha. Carvone has such effects as anticancer, antimicrobial, antioxidant, anti-inflammatory, antispasmodic, antinociceptive, anticonvulsant .

HY-N0182R

Fisetin (Standard) 30+ Cited Publications	Neurological Disease Classification of Application Fields Anti-aging Rosaceae Metabolic Disease Plants Flavonoids Phenols Inflammation/Immunology Disease Research Fields Fragaria × ananassa Duch. Source Classification Cancer	Reference Standards Sirtuin PPAR TNF Receptor
Fisetin (Standard) is the analytical standard of Fisetin. This product is intended for research and analytical applications. Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

HY-N0362

Columbianadin 4 Publications Verification	Classification of Application Fields Coumarins Phenylpropanoids Umbelliferae Plants Seriphidium transiliense Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis
Columbianadin, a natural coumarin from Heracleum hemsleyanum, is known to have various biological activities including anti-inflammatory and anti-cancer effects.

HY-W013573

S-Allyl-L-cysteine 1 Publications Verification	Productos naturales Liliaceae Neurological Disease Classification of Application Fields Anti-aging Metabolic Disease Allium sativum Linn. Plants Inflammation/Immunology Disease Research Fields Source Classification Cancer	Apoptosis
S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity.

HY-N2477

Taraxerol	Triterpenes Classification of Application Fields Terpenoids Astragalus oleifolius DC. Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis NF-κB
Taraxerol is isolated from Taraxacum mongolicum, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis .

HY-N6642

Ankaflavin	Productos naturales Microorganisms Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Source Classification	PPAR Apoptosis
Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects .

HY-N1408

trans-Trimethoxyresveratrol trans-trismethoxy Resveratrol; (E)-Resveratrol trimethyl ether; trans-3,5,4'-Trimethoxystilbene	other families Stilbenes Classification of Application Fields Plants Disease Research Fields Source Classification Cancer	VEGFR Reactive Oxygen Species (ROS) Caspase Apoptosis
Trans-Trimethoxyresveratrol (trans-trismethoxy Resveratrol; (E)-Resveratrol trimethyl ether; trans-3,5,4'-Trimethoxystilbene) is an orally active natural derivative of Resveratrol (HY-16561). Trans-Trimethoxyresveratrol has an enhanced anticancer profile compared to Resveratrol, exhibiting higher potency than resveratrol, with improved cancer cell proliferation inhibition, induction of cell cycle arrest, decreased metastasis, and increased apoptosis. Trans-Trimethoxyresveratrol causes microtubule disassembling and tubulin depolymerization and exerts anti-angiogenic effects through VEGFR2. Trans-Trimethoxyresveratrol can be used for the studies of anti-angiogenic and anti-cancer (such as non-small cell lung cancer and osteosarcoma) .

HY-N2521

Tetramethylcurcumin FLLL31	other families Classification of Application Fields Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	STAT Apoptosis
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects .

HY-126940

Furanodiene	Classification of Application Fields Terpenoids Sesquiterpenes Plants Curcuma longa Disease Research Fields Cancer Source Classification Zingiberaceae	Reactive Oxygen Species (ROS) P-glycoprotein Apoptosis
Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level .

HY-N2009

3-O-Methylgallic acid 3,4-Dihydroxy-5-methoxybenzoic acid	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	Apoptosis Caspase
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) is an anthocyanin metabolite and has potent antioxidant capacity. 3-O-methylgallic acid inhibits Caco-2 cell proliferation with an IC₅₀ value of 24.1 μM. 3-O-methylgallic acid also induces cell apoptosis and has anti-cancer effects .

HY-N0674A

Dehydrocorydaline chloride 40+ Cited Publications 13-Methylpalmatine chloride	Infection Alkaloids other families Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain .

HY-W748591

Cannflavin A	Flavonoids Cannabis sativa L Flavones Plants Moraceae Source Classification	Apoptosis Amyloid-β KMO
Cannflavin A can be isolated from Cannabis sativa L.. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ_1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO) (IC₅₀ = 29.4 μM). Cannflavin A activates apoptosis via caspase-3 cleavage. Cannflavin A exerts anti-inflammatory effects by inhibiting pro-inflammatory enzymes, including prostaglandin E2 and cytochrome c oxidases I and II in PC12 cell line .

HY-N8572

3',4'-Dimethoxyflavone 1 Publications Verification	Flavonoids other families Flavones Coniogramme japonica (Thunb.) Diels Plants	PARP Reactive Oxygen Species (ROS) Aryl Hydrocarbon Receptor
3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects .

Cat. No.	Nom du produit	Chemical Structure

HY-B1773AS3

Sodium propionate-13C3

Sodium propionate- ¹³C-3 is the ¹³C-labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-B0166S

L-Ascorbic acid-13C6

L-Ascorbic acid- ¹³C₆ is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-B0011S

Docetaxel-d9
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule?depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of?bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-B0166S8

L-Ascorbic acid-13C6-1

L-Ascorbic acid- ¹³C₆-1 (L-Ascorbate-1; Vitamin C- ¹³C₆-1) is a ¹³C labeled L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-17514S

Itraconazole-d5

Itraconazole-d₅ is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects .

HY-B0166S1

L-Ascorbic acid-13C

L-Ascorbic acid- ¹³C is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-17514S1

Itraconazole-d3

Itraconazole-d₃ (R51211-d₃) is the deuterium labeled Itraconazole (HY-17514) . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.

HY-N0573S

Umbelliferone-d5

Umbelliferone-d₅ (7-Hydroxycoumarin-d₅) is the deuterium labeled Umbelliferone (HY-N0573 ). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .

HY-B1773AS4

Sodium propionate-d5

Sodium propionate-d₅ is the deuterium labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-B1773AS

Sodium propionate-13C

Sodium propionate- ¹³C is the ¹³C labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-17412AS

Minocycline-d6

Minocycline-d₆ is deuterium labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-B0424S

Nitrendipine-d5

Nitrendipine-d₅ is the deuterium labeled Nitrendipine (HY-B0424). Nitrendipine (BAY-E-5009) is an orally active analog of Nifedipine (HY-B0284) and dihydropyridine calcium channel blocker. Nitrendipine induces Apoptosis. Nitrendipine has antihypertensive effects. Nitrendipine blocks alcohol and Morphine withdrawal symptoms. Nitrendipine reduces right ventricular hypertrophy and pulmonary vascular changes induced by intermittent hypoxia. Nitrendipine has anticancer effects on neuroblastoma .

HY-N1366S

Herniarin-d3
Herniarin-d₃ is the deuterium labeled Herniarin (HY-N1366). Herniarin is a natural coumarin occurs in some flowering plants with anticancer effects. Herniarin results in a significant decrease in cell viability by inducing apoptosis in MCF-7 cells. Herniarin also has anti-dermatophytic activity. Herniarin can be used for the study of bladder cancer and breast cancer .

HY-17514S2

Itraconazole-d9

Itraconazole-d₉ is the deuterium labeled Itraconazole . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-B1773AS5

Sodium propionate-d3

Sodium propionate-d₃ is the deuterium labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-10448S1

Capsaicin-d3
Capsaicin-d₃ is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects .

HY-10448S4

Capsaicin-d7
Capsaicin-d₇ is deuterated labeled Capsaicin (HY-10448). Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects .

HY-13777S1

Zoledronic acid-d3
Zoledronic acid-d₃ (Zoledronate-d₃) is the deuterium labeled Zoledronic acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

HY-B0114S

Oxcarbazepine-d4
Oxcarbazepine-d₄ (GP 47680-D₄) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Anti-cancer and anticonvulsant effects .

HY-17412S1

Minocycline-d6 sulfate

Minocycline-d₆ sulfate is deuterated labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-17412S

Minocycline-d6 hydrochloride

Minocycline-d₆ hydrochloride is deuterated labeled Minocycline hydrochloride (HY-17412). Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-W654256

Matrine-d3

Matrine-d₃ (Matridin-d₃) is a deuterium labeled Matrine (HY-N0164). Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .

HY-14393S

Emodin-d4

Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-W050154S

Kojic acid-13C6

Kojic acid- ¹³C₆ is ¹³C labeled Kojic acid (HY-W050154). Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .

HY-13777S

Zoledronic acid-d5
Zoledronic acid-d₅ is deuterated labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

HY-B0114S1

Oxcarbazepine-d4-1
Oxcarbazepine-d₄-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Anti-cancer and anticonvulsant effects .

HY-B0114S3

Oxcarbazepine-d10
Oxcarbazepine-d₁₀ (GP 47680-d₁₀) is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Anti-cancer and anticonvulsant effects .

HY-B0114S2

Oxcarbazepine-d8-1
Oxcarbazepine-d8-1 is a deuterium of Oxcarbazepine. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Oxcarbazepine-d8-1 has anti-cancer and anticonvulsant effects .

HY-W777154

Zoledronic acid-15N2,13C2
Zoledronic acid- ¹⁵N₂, ¹³C₂ (CGP 42446- ¹⁵N₂, ¹³C₂) is the ¹³C- and ¹⁵N-labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

HY-W654013

Minocycline-d7

Minocycline-d₇ is deuterium labeled Minocycline. Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-144378S

Thiorphan methoxyacetophenone derivative-d7
Thiorphan methoxyacetophenone derivative-d₇ is the deuterium labeled Thiorphan methoxyacetophenone derivative .

HY-B1619S

Cromolyn-d5

Cromolyn-d₅ (Cromoglycate-d₅) is the deuterium labeled Cromolyn (HY-B1619). Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-160219S

BTK-IN-33
BTK-IN-33 is a Btk inhibitor with anticancer effects (WO2023174300A1; compound I) .

HY-N0182S3

Fisetin-d5
Fisetin-d5 is a deuterated labeled Fisetin . Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

HY-B0667S

Balsalazide-d3
Balsalazide-d₃ is the deuterium labeled Balsalazide (HY-B0667). Balsalazide is a prodrug of amino salicylic acid that releases mesalamine (HY-15027) in the colon, offering various anti-inflammatory effects in areas of colitis, and it also exerts related anticancer effects by regulating the IL-6/STAT3 pathway .

HY-B0134S1

Bestatin-d10
Bestatin-d₁₀ (Ubenimex-d₁₀) is deuterium labeled Bestatin. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-131503S

13-Methyltetradecanoic acid-d6
13-Methyltetradecanoic acid-d6 is a deuterated labeled 13-Methyltetradecanoic acid . 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

HY-W777393

Umbelliferone-13C6

Umbelliferone- ¹³C₆ (7-Hydroxycoumarin- ¹³C₆) is the ¹³C-labeled Umbelliferone (HY-N0573). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .

HY-N6746S1

Citrinin-13C13

Citrinin- ¹³C₁₃ (NSC 186- ¹³C₁₃) is the ¹³C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-W653919

SN-38 glucuronide-d3
SN-38 glucuronide-d₃ is deuterium labeled SN-38 glucuronide. SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .

HY-B1550S

Benzoin-d10
Benzoin-d₁₀ (DL-Benzoin-d₁₀) is the deuterium labeled Benzoin (HY-B1550). Benzoin (DL-Benzoin), a natural balsamic resin, is a PI3Kα inhibitor with anticancer effects. Benzoin inihits the growth of colon cancer cell line (HCT-116). Benzoin can be used as a food additive .

HY-W767186

D-Mannoheptulose-13C7

D-Mannoheptulose- ¹³C₇ is the ¹³C-labeled D-Mannoheptulose. D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-U00462S

D-Mannoheptulose-13C

D-Mannoheptulose- ¹³C is the ¹³C labeled D-Mannoheptulose (HY-U00462) . D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-13716S

Noscapine-13C,d3

Noscapine- ¹³C,d₃ is a ¹³C- labeled and deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

HY-172733S

PRMT5-MTA-IN-3-d3

PRMT5-MTA-IN-3-d₃ (compound P22) is the deuterium labeled PRMT5-MTA-IN-3 (HY-172733). PRMT5-MTA-IN-3-d₃ is an orally active PRMT5-MTA inhibitor. PRMT5-MTA-IN-3-d₃ has antiproliferative effects on HTC116-MTAP del and wild type colorectal cancer HCT-116 cell lines, with IC₅₀ values of 6 nM and 961 nM, respectively. PRMT5-MTA-IN-3-d₃ has anticancer effects, especially for MTAP-deficient tumors, such as non-small cell lung cancer (NSCLC), pancreatic cancer .

HY-W751179

Midostaurin-13C6

Midostaurin- ¹³C₆ (PKC412- ¹³C₆) is the ¹³C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

HY-B1773AS1

Sodium propionate-13C-1

Sodium propionate- ¹³C-1 is the ¹³C-labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-W766368

C6 Ceramide-13C2,d2

C6 Ceramide- ¹³C₂,d₂ (C6-Cer- ¹³C₂,d₂) is the deuterium labeled and ¹³C-labeled C6 Ceramide (HY-19542). C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. C6 Ceramide exhibits multiple anti-cancer properties including cell cycle arrest, Apoptosis, inhibition of tumor growth and enhances the effects of chemotherapy in drug-resistant cancer cells. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .

HY-42487S1

Exatecan Intermediate 1-d2
Exatecan Intermediate 1-d₂ is the deuterium labeled Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor with anticancer effects.

HY-126373S

SN-38 glucuronide-d5
SN-38 glucuronide-d₅ (SN-38G-d₅) is the deuterium labeled SN-38 glucuronide (HY-126373). SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer.

Cat. No.	Nom du produit	Target	Áreas de investigación	Chemical Structure

HY-B0166GL

L-Ascorbic acid (GMP Like) L-Ascorbate (GMP Like); Vitamin C (GMP Like)	Reactive Oxygen Species (ROS) Apoptosis Calcium Channel Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
L-Ascorbic acid (GMP Like) is the GMP Like class L-Ascorbic acid (HY-B0166). L-Ascorbic acid (L-Ascorbate, Vitamin C), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

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