1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. USP7-IN-8

USP7-IN-8 

Cat. No.: HY-134817 Purity: 98.80%
Handling Instructions

USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects.

For research use only. We do not sell to patients.

USP7-IN-8 Chemical Structure

USP7-IN-8 Chemical Structure

CAS No. : 2009273-60-1

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1].

IC50 & Target

IC50: 1.4 μM (USP7)

In Vitro

USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

347.41

Formula

C₂₁H₂₁N₃O₂

CAS No.
SMILES

O=C(NC)C1=CC=C(C2=C(CC)C(C3=CC=C(O)C=C3)=C(N)N=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (239.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8784 mL 14.3922 mL 28.7844 mL
5 mM 0.5757 mL 2.8784 mL 5.7569 mL
10 mM 0.2878 mL 1.4392 mL 2.8784 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.99 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.99 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.80%

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Keywords:

USP7-IN-8DeubiquitinaseDUBsUSP7anticancerInhibitorinhibitorinhibit

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Product Name:
USP7-IN-8
Cat. No.:
HY-134817
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