1. Apoptosis
  2. Apoptosis
  3. Picrocrocin

Picrocrocin 

Cat. No.: HY-N4114
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Picrocrocin, an apocarotenoid found in the flowers of Cochliobolus sativus. Picrocrocin shows anticancer effect. Picrocrocin exhibits growth inhibitory effects against SKMEL-2 human malignant melanoma cells.

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Picrocrocin Chemical Structure

Picrocrocin Chemical Structure

CAS No. : 138-55-6

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Description

Picrocrocin, an apocarotenoid found in the flowers of Cochliobolus sativus. Picrocrocin shows anticancer effect. Picrocrocin exhibits growth inhibitory effects against SKMEL-2 human malignant melanoma cells[1].

In Vitro

Picrocrocin exerted growth inhibitory effects on the SK-MEL-2 melanoma cells. The IC50 of picrocrocin against the SK-MEL-2 cells was 20 μM at 24-h incubation. The antiproliferative activity of picrocrocin was due to apoptosis and cell cycle arrest. In addition, picrocrocin enhanced the ROS levels and decreased the MMP levels of SK-MEL-2 cells. Finally, picrocrocin inhibited the JAK/STAT5 signalling pathway in the SK-MEL-2 melanoma cells[1].

Molecular Weight

330.37

Formula

C₁₆H₂₆O₇

CAS No.

138-55-6

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Keywords:

PicrocrocinApoptosisSKMEL-2cellshumanmalignantmelanomacyclearrestantiproliferativeInhibitorinhibitorinhibit

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