Fostroxacitabine bralpamide
Fostroxacitabine bralpamide (MIV-818) is an orally active Troxacitabine-based nucleotide proagent. Fostroxacitabine bralpamide has anticancer effects.
For research use only. We do not sell to patients.
- CAS No.: 2129993-56-0
- Formula: C22H30BrN4O8P
- Molecular Weight:589.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Fostroxacitabine bralpamide (MIV-818) is highly metabolized by human hepatocytes, directing high levels of the chain-terminating nucleotide tri-phosphate to the liver. The tri-phosphate is incorporated into DNA during replication, which leads to DNA double strand breaks, DNA damage responses, and cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2129993-56-0
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Molecular Weight 589.37
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Formula C22H30BrN4O8P
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SMILES
O=C1N([C@@]2([H])O[C@H](OC2)COP(OC3=CC=C(C=C3)Br)(N[C@@H](C)C(O[C@@H](C)CCC)=O)=O)C=CC(N)=N1
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Synonyms
MIV-818
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fostroxacitabine bralpamide Related Classifications
HY-132815 Related Classifications
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