CXCL-CXCR1/2-IN-1
Based on 1 publication(s) in Google Scholar
CXCL-CXCR1/2-IN-1 is an orally active ELR+CXCL-CXCR1/2 pathway inhibitor with an EC50 of 42.7 nM for CXCR2. CXCL-CXCR1/2-IN-1 shows anticancer and antiangiogenic effects.
For research use only. We do not sell to patients.
- Purity: 99.64%
- CAS No.: 2415653-55-1
- Formula: C14H8Cl2N4O3S
- Molecular Weight:383.21
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CXCL-CXCR1/2-IN-1
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 786-0 | IC50 |
2.5 μM
Compound: 10
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Antiproliferative activity against human 786-0 cells incubated for 48 hrs by XTT assay
Antiproliferative activity against human 786-0 cells incubated for 48 hrs by XTT assay
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[PMID: 38894897] |
| A498 | IC50 |
2 μM
Compound: 10
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Antiproliferative activity against human A498 cells incubated for 48 hrs by XTT assay
Antiproliferative activity against human A498 cells incubated for 48 hrs by XTT assay
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[PMID: 38894897] |
| CAL-27 | IC50 |
2.5 μM
Compound: 10
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Antiproliferative activity against human CAL-27 cells incubated for 48 hrs by XTT assay
Antiproliferative activity against human CAL-27 cells incubated for 48 hrs by XTT assay
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[PMID: 38894897] |
| CAL-33 | IC50 |
4 μM
Compound: 10
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Antiproliferative activity against human CAL-33 cells incubated for 48 hrs by XTT assay
Antiproliferative activity against human CAL-33 cells incubated for 48 hrs by XTT assay
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[PMID: 38894897] |
| RCC4 | IC50 |
2 μM
Compound: 10
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Antiproliferative activity against human RCC4 cells incubated for 48 hrs by XTT assay
Antiproliferative activity against human RCC4 cells incubated for 48 hrs by XTT assay
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[PMID: 38894897] |
In renal cell carcinoma (RCC) cell lines (A498, RCC4, 786, and Sunitinib-resistant RCC cell line 786-R) and neck squamous cell carcinoma (HNSCC) cell lines (CAL33, CAL27, Cisplatin- and radiotherapy-resistant cell lines CAL33RR and CAL27RR), CXCL-CXCR1/2-IN-1 (compound 10) shows IC50 values of 2 μM, 2 μM, 2.5 μM, 2 μM, 3 μM, 4 μM, 4 μM, 2.5 μM, and 2.5 μM against A498, RCC4, 786, 786-R, CAL33, CAL27, CAL33RR, and CAL27RR, respectively[1].
CXCL-CXCR1/2-IN-1 inhibits the migration of A498 cancer cells in vitro[1].
CXCL-CXCR1/2-IN-1 (1-2.5 μM; 24-48 h) shows a reduction in the phosphorylation of ERK and AKT in A498 cells. CXCL-CXCR1/2-IN-1 also exhibits the capability to inhibit the secretion of CXCL1, CXCL5, and CXCL8, which are representative proangiogenic ELR+CXCL cytokines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A498 cells
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Concentration:2.5 μM
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Incubation Time:24 or 48 h
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Result:Showed a reduction in the phosphorylation of ERK and AKT.
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Cell Line:A498 cells
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Concentration:1 or 2.5 μM
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Incubation Time:48 h
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Result:Inhibited the levels of CXCL1, CXCL5, CXCL8, and VEGFA mRNA.
CXCL-CXCR1/2-IN-1 (100 mg/kg; oral gavage; twice a day; for 28 days) inhibits tumor growth in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female NOD SCID mice injected with 786 RCC cells[1]
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Dosage:100 mg/kg
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Administration:Oral gavage; twice a day; for 28 days
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Result:Exhibited remarkable results, with a tumor growth inhibition rate of 87%.
Chemical Information
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CAS No. 2415653-55-1
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Appearance Solid
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Molecular Weight 383.21
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Formula C14H8Cl2N4O3S
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Color Off-white to light yellow
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SMILES
O=C(NC1=NC2=CC=C([N+]([O-])=O)C=C2S1)NC3=CC(Cl)=CC(Cl)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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ACS Nano
Charge-Adaptive Nanoparticle Attenuates Inflammation via Targeting Neutrophil Extracellular Traps (NETs) and Breaking NETs-Macrophage Crosstalk. [Abstract]2026 Mar 17;20(10):8936-8957. PMID: 41773759
Solvent & Solubility
DMSO : 4.17 mg/mL (10.88 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6095 mL | 13.0477 mL | 26.0954 mL | 65.2384 mL |
| 5 mM | 0.5219 mL | 2.6095 mL | 5.2191 mL | 13.0477 mL | |
| 10 mM | 0.2610 mL | 1.3048 mL | 2.6095 mL | 6.5238 mL |
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