O-Demethylmurrayanine
O-Demethylmurrayanine is a natural phenol with anticancer effects. O-Demethylmurrayanine exhibits strong cytotoxicity against MCF-7 and SMMC-7721 with IC50 values in the range 4.42-7.59 μg/mL.
For research use only. We do not sell to patients.
- CAS No.: 123497-84-7
- Formula: C13H9NO2
- Molecular Weight:211.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| KB | IC50 |
5.49 μM
Compound: 11
|
Cytotoxicity against human KB cells by resazurin microplate assay
Cytotoxicity against human KB cells by resazurin microplate assay
|
[PMID: 21302964] |
| NCI-H187 | IC50 |
19.22 μM
Compound: 11
|
Cytotoxicity against human NCI-H187 by resazurin microplate assay
Cytotoxicity against human NCI-H187 by resazurin microplate assay
|
[PMID: 21302964] |
| Neutrophil | IC50 |
3.5 μM
Compound: 18
|
Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced superoxide anion generation pretreated for 5 mins by spectrophotometry
Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced superoxide anion generation pretreated for 5 mins by spectrophotometry
|
[PMID: 24798144] |
| Neutrophil | IC50 |
6.9 μM
Compound: 18
|
Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced elastase release for 5 mins
Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced elastase release for 5 mins
|
[PMID: 24798144] |
| Vero | IC50 |
103.5 μM
Compound: 11
|
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
|
[PMID: 21302964] |
Chemical Information
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CAS No. 123497-84-7
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Molecular Weight 211.22
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Formula C13H9NO2
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SMILES
O=CC1=CC2=C(C(O)=C1)NC3=C2C=CC=C3
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)