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Cat. No.: HY-186161

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Antiproliferative agent-77

Antiproliferative agent-77 is an anticancer cell proliferation agent that exerts significant antiproliferative effects on HCT116, HepG2, H1299 and MCF-7.

For research use only. We do not sell to patients.

CAS No.: 1446686-55-0
Formula: C₂₃H₁₈N₄O₃S
Molecular Weight:430.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antiproliferative agent-77 Chemical Structure

CAS No.: 1446686-55-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antiproliferative agent-77 is an anticancer cell proliferation agent that exerts significant antiproliferative effects on HCT116, HepG2, H1299 and MCF-7^[1].

In Vitro

Antiproliferative agent-77 (Positive control L029) (3.125-100 μM; 2 days) potently inhibits the proliferation of HCT116, HepG2, H1299 and MCF-7 cells, with IC₅₀ values of 14.25 μM, 22.05 μM, 13.69 μM and 28.21 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HCT116 (human colon cancer), HepG2 (human liver cancer), H1299 (human lung adenocarcinoma), MCF-7 (human breast cancer)
Concentration:

3.125, 6.25, 12.5, 25, 50 and 100 μM
Incubation Time:

2 days (drug incubation); 1 day (pre-culture); 2 hours (MTS incubation)
Result:

Potently inhibited proliferation of HCT116 cells with an IC₅₀ of 14.25 μM.
Potently inhibited proliferation of HepG2 cells with an IC₅₀ of 22.05 μM.
Potently inhibited proliferation of H1299 cells with an IC₅₀ of 13.69 μM.
Potently inhibited proliferation of MCF-7 cells with an IC₅₀ of 28.21 μM.

Chemical Information

CAS No. 1446686-55-0
Molecular Weight 430.48
Formula C₂₃H₁₈N₄O₃S
SMILES

O=C1NC2=CC=C(S(=O)(NC3=C(C)C=CC=C3)=O)C=C2/C1=C/C4=NC5=C(N4)C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Deng, et al. The application of macrocarpal B or macrocarpal C in treating breast cancer. CN108771663A.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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