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  4. Antiproliferative agent-77

Antiproliferative agent-77 is an anticancer cell proliferation agent that exerts significant antiproliferative effects on HCT116, HepG2, H1299 and MCF-7.

For research use only. We do not sell to patients.

Antiproliferative agent-77

Antiproliferative agent-77 Chemical Structure

CAS No. : 1446686-55-0

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Antiproliferative agent-77 Related Antibodies

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Description

Antiproliferative agent-77 is an anticancer cell proliferation agent that exerts significant antiproliferative effects on HCT116, HepG2, H1299 and MCF-7[1].

In Vitro

Antiproliferative agent-77 (Positive control L029) (3.125-100 μM; 2 days) potently inhibits the proliferation of HCT116, HepG2, H1299 and MCF-7 cells, with IC50 values of 14.25 μM, 22.05 μM, 13.69 μM and 28.21 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiproliferative agent-77 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HCT116 (human colon cancer), HepG2 (human liver cancer), H1299 (human lung adenocarcinoma), MCF-7 (human breast cancer)
Concentration: 3.125, 6.25, 12.5, 25, 50 and 100 μM
Incubation Time: 2 days (drug incubation); 1 day (pre-culture); 2 hours (MTS incubation)
Result: Potently inhibited proliferation of HCT116 cells with an IC50 of 14.25 μM.
Potently inhibited proliferation of HepG2 cells with an IC50 of 22.05 μM.
Potently inhibited proliferation of H1299 cells with an IC50 of 13.69 μM.
Potently inhibited proliferation of MCF-7 cells with an IC50 of 28.21 μM.
Molecular Weight

430.48

Formula

C23H18N4O3S
CAS No.
SMILES

O=C1NC2=CC=C(S(=O)(NC3=C(C)C=CC=C3)=O)C=C2/C1=C/C4=NC5=C(N4)C=CC=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiproliferative agent-77 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-771446686-55-0Antiproliferative agent77Antiproliferative agent 77Othershuman lung adenocarcinomaHCT116human colon cancerHepG2MCF-7human liver cancerH1299human breast cancerInhibitorinhibitorinhibit

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