Rabdosin B 

Rabdosin B is an ent-kaurene diterpenoid with anticancer effects. Rabdosin B induces DNA damage in cells, and inhibits lettuce root hair development of seedlings^[1][2].

Rabdosin B (200 μM; 3-12 h) induces cell cycle retardation of the G2 phase and S phase in root meristematic cells. Rabdosin B shows a time- and dose-dependent increase in DNA damage^[1].
Rabdosin B shows a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in lettuce seedlings (Lactuca sativa L.). Lower concentrations of Rabdosin B (20-80 μM) significantly promots root growth, but its higher levels at 120-200 μM, by contrast, has inhibitory effects. Additionally, all tested concentrations (10-40 μM) inhibits root hair development of seedlings in a dose-dependent manner^[1].
Rabdosin B has cytotoxic against human tumour HepG2, GLC-82 and HL-60 cell lines with IC₅₀ values of 8.95 μM, 4.47 μM and 10.22 μM, respectively^[2].
Rabdosin B (6 μM, 9 μM, 12 μM, 15 μM; 24-48 hours) induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

448.51

C₂₄H₃₂O₈

84304-92-7

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• [1]. Lan Ding, et al. Regulation of cell division and growth in roots of Lactuca sativa L. seedlings by the Ent-Kaurene diterpenoid rabdosin B. J Chem Ecol. 2010 May;36(5):553-63.  [Content Brief]

  [2]. Lan Ding, et al. Comparison of cytotoxicity and DNA damage potential induced by ent-kaurene diterpenoids from Isodon plant. Nat Prod Res. 2011 Sep;25(15):1402-11.  [Content Brief]