Flt-3 Inhibitor III
Flt-3 Inhibitor III is a potent and selective FLT3 kinase inhibitor with an 50 of 50 nM. Flt-3 Inhibitor III shows less active against other kinases. Flt-3 Inhibitor III has anticancer effects.
For research use only. We do not sell to patients.
- CAS No.: 852045-46-6
- Formula: C21H23N3OS
- Molecular Weight:365.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Tie2 8.0 μM (IC50) |
Flt-3 Inhibitor III (compound 4) also inhibits c-Kit, KDR, c-Abl, CDK1, c-Src and Tie-2 with IC50 values of 0.26 μM, 0.91 μM, 1.2 μM, 2.1 μM, 2.8 μM, and 8.0 μM, respectively[1].
Flt-3 Inhibitor III (compound 4) blocks the proliferation of BaF3-ITD, BaF3-D835/Y, and MV4:11 cells, with IC50 values of 0.24 μM, 0.76 μM, and 0.052 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 852045-46-6
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Molecular Weight 365.49
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Formula C21H23N3OS
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SMILES
C1(NC2=CC=C(OCCN3CCCC3)C=C2)=NC=C(C4=CC=CC=C4)S1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Flt-3 Inhibitor III Related Classifications
HY-112475 Related Classifications
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