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Cat. No.: HY-151953

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Antitubulin agent 1

Antitubulin agents-1 is an antitubulin agent that induces disruption of the microtubules (Microtubule/Tubulin) and increases α-tubulin acetylation. Antitubulin agents-1 has anticancer effects. Antitubulin agent 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Formula: C₂₁H₁₉N₃O₃
Molecular Weight:361.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Antitubulin agent 1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Antitubulin agents-1 is an antitubulin agent that induces disruption of the microtubules (Microtubule/Tubulin) and increases α-tubulin acetylation. Antitubulin agents-1 has anticancer effects^[1]. Antitubulin agent 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cellular Effect

Cell Line	Type	Value	Description	References
SH-SY5Y	EC₅₀	102 nM Compound: 143	Cytotoxicity against human SH-SY5Y cells incubated for 48 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells incubated for 48 hrs by MTT assay	[PMID: 36370553]

In Vitro

Antitubulin agents-1 (compound 143) shows cytotoxic in human neuroblastoma SH-SY5Y cells with an EC₅₀ of 102 nM^[1].
Antitubulin agents-1 (compound 143; 1 μM; for 16 h) is able to induce a statistically significant G2/M cell cycle arrest at 1 μM. Antitubulin agents-1 also inhibits polymerization^[1].
Antitubulin agents-1 (compound 143; 0.1-1 μM; for 16 h) leads to a significant increase in tubulin acetylation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

SH-SY5Y cells
Concentration:

1 μM
Incubation Time:

16 h
Result:

Induced a statistically significant G2/M cell cycle arrest at 1 μM.

Western Blot Analysis^[1]

Cell Line:

SH-SY5Y cells
Concentration:

100 nM, 300 nM, 500 nM, 1000 nM
Incubation Time:

16 h
Result:

Increased the acetylated α-tubulin levels.

Chemical Information

Molecular Weight 361.39
Formula C₂₁H₁₉N₃O₃
SMILES

C#CCOC1=CC(N/C(C)=C2C(NN(C\2=O)CC3=CC=CC=C3)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Arash Foroutan, et al. Identification of novel aza-analogs of TN-16 as disrupters of microtubule dynamics through a multicomponent reaction. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114895. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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