1. Cell Cycle/DNA Damage Cytoskeleton
  2. Microtubule/Tubulin
  3. Antitubulin agent 1

Antitubulin agents-1 is an antitubulin agent that induces disruption of the microtubules (Microtubule/Tubulin) and increases α-tubulin acetylation. Antitubulin agents-1 has anticancer effects. Antitubulin agent 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Antitubulin agent 1 Chemical Structure

Antitubulin agent 1 Chemical Structure

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Description

Antitubulin agents-1 is an antitubulin agent that induces disruption of the microtubules (Microtubule/Tubulin) and increases α-tubulin acetylation. Antitubulin agents-1 has anticancer effects[1]. Antitubulin agent 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

Antitubulin agents-1 (compound 143) shows cytotoxic in human neuroblastoma SH-SY5Y cells with an EC50 of 102 nM[1].
Antitubulin agents-1 (compound 143; 1 μM; for 16 h) is able to induce a statistically significant G2/M cell cycle arrest at 1 μM. Antitubulin agents-1 also inhibits polymerization[1].
Antitubulin agents-1 (compound 143; 0.1-1 μM; for 16 h) leads to a significant increase in tubulin acetylation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 1 μM
Incubation Time: 16 h
Result: Induced a statistically significant G2/M cell cycle arrest at 1 μM.

Western Blot Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 100 nM, 300 nM, 500 nM, 1000 nM
Incubation Time: 16 h
Result: Increased the acetylated α-tubulin levels.
Molecular Weight

361.39

Formula

C21H19N3O3

SMILES

C#CCOC1=CC(N/C(C)=C2C(NN(C\2=O)CC3=CC=CC=C3)=O)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Antitubulin agent 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Antitubulin agent 1
Cat. No.:
HY-151953
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