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Cat. No.: HY-155018

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Anticancer agent 127

Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC₅₀s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects.

For research use only. We do not sell to patients.

CAS No.: 2410953-19-2
Formula: C₂₆H₃₇FN₄O₆S
Molecular Weight:552.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Anticancer agent 127 Chemical Structure

CAS No.: 2410953-19-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 12 nM (XIAP-BIR3), 14 nM (cIAP1-BIR3), and 9 nM (cIAP2-BIR3)^[1]

All IAP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	EC₅₀	44 nM Compound: 142D6	Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging analysis Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging analysis	[PMID: 37262387]
MDA-MB-231	EC₅₀	61 nM Compound: 142D6	Induction of apoptosis in human MDA-MB-231 cells Induction of apoptosis in human MDA-MB-231 cells	[PMID: 37262387]
MDA-MB-231	EC₅₀	94.2 nM Compound: 142D6	Cytotoxicity against human MDA-MB-231 cells cultured as 3D spheroids incubated for 6 days and measured every 6 hrs by IncuCyte live-cell analysis Cytotoxicity against human MDA-MB-231 cells cultured as 3D spheroids incubated for 6 days and measured every 6 hrs by IncuCyte live-cell analysis	[PMID: 37262387]

Chemical Information

CAS No. 2410953-19-2
Molecular Weight 552.66
Formula C₂₆H₃₇FN₄O₆S
SMILES

O=C(N1[C@H](C(N[C@H]2C(C=CC=C3OS(=O)(F)=O)=C3CC2)=O)CCC1)[C@H](C4CCCCC4)NC([C@H](C)NC)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Udompholkul P, et al. Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J Med Chem. 2023 Jun 22;66(12):8159-8169. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Anticancer agent 127

All IAP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Anticancer agent 127 Related Classifications

HY-155018 Related Classifications