1. Apoptosis
    Membrane Transporter/Ion Channel
  2. MDM-2/p53
    P-glycoprotein
  3. Anticancer agent 50

Anticancer agent 50 

Cat. No.: HY-146389
Handling Instructions

Anticancer agent 50 (compound 6) is a potent ABCB1 efflux pump modulator. Anticancer agent 50 shows cytotoxic effects and antiproliferative effects. Anticancer agent 50 decreases the expression of cyclin D1 and induces p53 expression. Anticancer agent 50 has the potential for the research of T-lymphoma.

For research use only. We do not sell to patients.

Anticancer agent 50 Chemical Structure

Anticancer agent 50 Chemical Structure

CAS No. : 2487457-15-6

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Description

Anticancer agent 50 (compound 6) is a potent ABCB1 efflux pump modulator. Anticancer agent 50 shows cytotoxic effects and antiproliferative effects. Anticancer agent 50 decreases the expression of cyclin D1 and induces p53 expression. Anticancer agent 50 has the potential for the research of T-lymphoma[1].

In Vitro

Anticancer agent 50 (compound 6) (0-100 µM) shows cytotoxic effects with IC50s of 0.67, 0.90 µM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively[1].
Anticancer agent 50 (0-100 µM) shows antiproliferative effects with IC50s of 3.84, 1.34 µM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively[1].
Anticancer agent 50 (0.1, 0.5, 2 µM; 24 h) inhibits cell cycle progression through the reduction of the expression of cyclin D1 and inhibits cell proliferation by inducing p53 expression[1].
Anticancer agent 50 (0.1, 0.5, 2, 10 µM; 72 h) inhibits cell growth by 12% in SH-SY5Y cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: JURKAT cells
Concentration: 0.1, 0.5, 2 µM
Incubation Time: 24 h
Result: Significantly reduced cyclin D1 expression and increased the level of p53.
Molecular Weight

563.55

Formula

C30H32N2O4Se

CAS No.
SMILES

COC(CN1C(N(C(C2=CC=CC=C2)(C1=O)C3=CC=CC=C3)CCCCCC[Se]C4=CC=CC=C4)=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Anticancer agent 50
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