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Cat. No.: HY-163180

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AKT-IN-22

AKT-IN-22 (compound 0R4) is a potent AKT allosteric inhibitor with anticancer effects.

For research use only. We do not sell to patients.

CAS No.: 1313880-28-2
Formula: C₃₃H₂₆FN₇O₂
Molecular Weight:571.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

AKT-IN-22 Chemical Structure

CAS No.: 1313880-28-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

AKT-IN-22 (compound 0R4) is a potent AKT allosteric inhibitor with anticancer effects^[1].

All Akt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.027 μM Compound: 12j	Inhibition of Akt1 in human A2780 cells assessed as phosphorylation of Akt at S473 after 2 hrs by Western Blot analysis Inhibition of Akt1 in human A2780 cells assessed as phosphorylation of Akt at S473 after 2 hrs by Western Blot analysis	[PMID: 22533986]
A2780	IC₅₀	0.032 μM Compound: 12j	Inhibition of Akt 1 in human A2780 cells assessed as phosphorylation of Akt at T308 after 2 hrs by Western Blot analysis Inhibition of Akt 1 in human A2780 cells assessed as phosphorylation of Akt at T308 after 2 hrs by Western Blot analysis	[PMID: 22533986]
A2780	IC₅₀	0.25 μM Compound: 12j	Inhibition of Akt1 in human A2780 cells assessed as phosphorylation PRAS40 at T246 after 2 hrs by Western Blot analysis Inhibition of Akt1 in human A2780 cells assessed as phosphorylation PRAS40 at T246 after 2 hrs by Western Blot analysis	[PMID: 22533986]
A2780	IC₅₀	2.2 μM Compound: 12j	Antiproliferative activity against human A2780 cells after 72 hrs by MTS assay Antiproliferative activity against human A2780 cells after 72 hrs by MTS assay	[PMID: 22533986]
AN3-CA	IC₅₀	0.044 μM Compound: 12j	Inhibition of Akt1 in human AN3CA cells assessed as phosphorylation of Akt at S473 after 2 hrs by Western Blot analysis Inhibition of Akt1 in human AN3CA cells assessed as phosphorylation of Akt at S473 after 2 hrs by Western Blot analysis	[PMID: 22533986]
AN3-CA	IC₅₀	0.045 μM Compound: 12j	Inhibition of Akt 1 in human AN3CA cells assessed as phosphorylation of Akt at T308 after 2 hrs by Western Blot analysis Inhibition of Akt 1 in human AN3CA cells assessed as phosphorylation of Akt at T308 after 2 hrs by Western Blot analysis	[PMID: 22533986]
AN3-CA	IC₅₀	0.22 μM Compound: 12j	Inhibition of Akt1 in human AN3CA cells assessed as phosphorylation PRAS40 at T246 after 2 hrs by Western Blot analysis Inhibition of Akt1 in human AN3CA cells assessed as phosphorylation PRAS40 at T246 after 2 hrs by Western Blot analysis	[PMID: 22533986]
AN3-CA	IC₅₀	2 μM Compound: 12j	Antiproliferative activity against human AN3CA cells after 72 hrs by MTS assay Antiproliferative activity against human AN3CA cells after 72 hrs by MTS assay	[PMID: 22533986]
Sf9	IC₅₀	0.005 μM Compound: 12j	Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assay Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assay	[PMID: 22533986]
Sf9	IC₅₀	0.018 μM Compound: 12j	Inhibition of Akt2 (1 to 481) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assay Inhibition of Akt2 (1 to 481) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assay	[PMID: 22533986]
Sf9	IC₅₀	0.17 μM Compound: 12j	Inhibition of Akt3 (1 to 479) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assay Inhibition of Akt3 (1 to 479) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assay	[PMID: 22533986]

Chemical Information

CAS No. 1313880-28-2
Molecular Weight 571.60
Formula C₃₃H₂₆FN₇O₂
SMILES

O=C(C1=CC(F)=CC=C1)NCC2=CC=C(N3C4=C(N=C3C5=CC=CN=C5N)C=CC(C6=CC(NC(C)=O)=CC=C6)=N4)C=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Karunakaran K, et al. Integrating machine learning and high throughput screening for the discovery of allosteric AKT1 inhibitors. J Biomol Struct Dyn. 2023 Dec 14:1-22. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Purity & Documentation
References

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AKT-IN-22

All Akt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AKT-IN-22 Related Classifications

HY-163180 Related Classifications