1. Apoptosis
  2. Apoptosis
  3. 27-TBDMS-4-Dehydrowithaferin A

27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent.

For research use only. We do not sell to patients.

27-TBDMS-4-Dehydrowithaferin A Chemical Structure

27-TBDMS-4-Dehydrowithaferin A Chemical Structure

CAS No. : 1214886-31-3

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Based on 1 publication(s) in Google Scholar

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Description

27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent[1].

In Vitro

27-TBDMS-4-Dehydrowithaferin A (compound 9b; 48 h) exhibits potent antiproliferative effects on HeLa (IC50=1.7 μM), A-549 (IC50=5.3 μM), MCF-7 (IC50=0.5 μM), and normal Vero cells (IC50=3.1 μM)[1].
27-TBDMS-4-Dehydrowithaferin A (24 μM; 48 h) activates caspase-3 in HeLa cells[1].
27-TBDMS-4-Dehydrowithaferin A (8 μM; 1-4 h) with a longer incubation period (2-4 h) leads to apoptosis, effect that was maintained at concentrations of 12 and 16 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

582.84

Formula

C34H50O6Si

CAS No.
SMILES

C[C@]12[C@@]3(C(C=CC2=O)=O)[C@](C[C@]4([H])[C@]1([H])CC[C@]5([C@@]4([H])CC[C@]5([H])[C@@H]([C@@]6([H])CC(C)=C(C(O6)=O)CO[Si](C)(C)C(C)(C)C)C)C)([H])O3

Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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27-TBDMS-4-Dehydrowithaferin A Related Classifications

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27-TBDMS-4-Dehydrowithaferin A
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HY-N10355
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