2. Apoptosis Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Apoptosis Caspase Mitochondrial Metabolism Reactive Oxygen Species (ROS)
  4. Stigmalactam

Stigmalactam is an aristolactam-type alkaloid extracted from Orophea enterocarpa with anticancer effects. Stigmalactam induces apoptosis via the mitochondrial pathway, with the activation of caspase-3/9, and a decrease in mitochondrial membrane potential (MTP). Stigmalactam exhibits antioxidant activity by decreasing ROS production. Stigmalactam can be used for liver and breast cancer research.

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Stigmalactam

Stigmalactam Chemical Structure

CAS No. : 289499-72-5

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Stigmalactam Related Antibodies

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Description

Stigmalactam is an aristolactam-type alkaloid extracted from Orophea enterocarpa with anticancer effects. Stigmalactam induces apoptosis via the mitochondrial pathway, with the activation of caspase-3/9, and a decrease in mitochondrial membrane potential (MTP). Stigmalactam exhibits antioxidant activity by decreasing ROS production. Stigmalactam can be used for liver and breast cancer research[1].

In Vitro

Stigmalactam (24 h) dose-dependently inhibits HepG2, MDA-MB-231 and murine fibroblast NIH3T cells growth with IC50 values of 22.98, 33.23 and 24.44 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Stigmalactam Related Antibodies
Molecular Weight

325.32

Formula

C18H15NO5
CAS No.
SMILES

O=C1NC2=CC3=CC=C(C=C3C4=C2C1=C(OC)C(OC)=C4OC)O
Structure Classification
Initial Source
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Stigmalactam Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stigmalactam289499-72-5ApoptosisCaspaseMitochondrial MetabolismReactive Oxygen Species (ROS)HepG2MDA-MB-231murine fibroblast NIH3Taristolactam-type alkaloidliver cancerbreast cancerInhibitorinhibitorinhibit

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