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Cat. No.: HY-124629A

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DB2313 tetrahydrochloride

7 Cited Publications

Customer Review

Based on 7 publication(s) in Google Scholar

DB2313 tetrahydrochloride is a potent transcription factor PU.1 inhibitor with an apoptosis of 14 nM. DB2313 tetrahydrochloride disrupts the interaction of PU.1 with target gene promoters. DB2313 tetrahydrochloride induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects.

For research use only. We do not sell to patients.

CAS No.: 2170606-75-2
Formula: C₄₂H₄₅Cl₄FN₈O₂
Molecular Weight:854.67

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

DB2313 tetrahydrochloride Chemical Structure

CAS No.: 2170606-75-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 2170606-75-2
Molecular Weight 854.67
Formula C₄₂H₄₅Cl₄FN₈O₂
SMILES

FC1=C(COC2=CC=C(C3=NC4=CC=C(C(NC(C)C)=N)C=C4N3)C=C2)C=CC=C1COC5=CC=C(C6=NC7=CC=C(C(NC(C)C)=N)C=C7N6)C=C5.Cl.Cl.Cl.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (7)

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Journal Impact Factor

Ann Rheum Dis

Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development. [Abstract]

2024 Aug 20:ard-2024-226067. PMID: 39164066

DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067. [Abstract]

DB2313 (0.3 mg; i.p.; once every 3 d) downregulated IL-9 expression and the proportions of Th9 cells in the spleen and PBMCs of collagen-induced arthritis (CIA) mice.

DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067. [Abstract]

PU.1 inhibitor DB2313 (0.3 mg; i.p.; once every 3 d) suppressed IL-9 release from Th9 cells of collagen-induced arthritis (CIA) mice.

DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067. [Abstract]

Effect of PU.1 inhibitor DB2313 (0.3 mg; i.p.; once every 3 d) on joint neovascularization in collagen-induced arthritis (CIA) mice.
Nat Commun

DNA-PK-mediated phosphorylation of STAT6 establishes a non-canonical type 2 immunity axis to prevent macrophage senescence. [Abstract]

2026 Feb 24;17(1):3123. PMID: 41735318
Nat Commun

Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions. [Abstract]

2025 Aug 4;16(1):7134. PMID: 40759647

DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 4;16(1):7134. [Abstract]

DB2313 (660 nM) inhibited the transcription of CSF1R, CALM1, and SLC2A3 while promoting E2F in neutrophils.

DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 4;16(1):7134. [Abstract]

DB2313 (17 mg/kg; i.p.) decreased serum levels of MMP9 and MPO/DNA‐NETs in the murine MI/RI model.
Adv Sci (Weinh)

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury. [Abstract]

2025 Jun;12(21):e2415205. PMID: 40151877
Chem Biol Interact

4-Hydroxybenzoic acid restrains Nlrp3 inflammasome priming and activation via disrupting PU.1 DNA binding activity and direct antioxidation. [Abstract]

2024 Dec 1:404:111262. PMID: 39389441
J Craniofac Surg

PU.1 Inhibition Attenuates Neuroinflammation and Pyroptosis After Traumatic Brain Injury by Modulating Microglial Polarization. [Abstract]

2026 Mar 2. PMID: 41769894
McGill University

2026.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Iléana Antony-Debré, et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest. 2017 Dec 1;127(12):4297-4313. [Content Brief]

[2]. Zhang S, Zhao S, Qi Y, et al. SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner. Mol Ther Nucleic Acids. 2022;27:699-717. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

DB2313 tetrahydrochloride

7 Cited Publications

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Biological Activity
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Publications (7)
Purity & Documentation
References

1/16
1/16

DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 4;16(1):7134. [Abstract]

Customer Validation
DB2313 (660 nM) inhibited the transcription of CSF1R, CALM1, and SLC2A3 while promoting E2F in neutrophils.
1/16

DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 4;16(1):7134. [Abstract]

Customer Validation
DB2313 (17 mg/kg; i.p.) decreased serum levels of MMP9 and MPO/DNA‐NETs in the murine MI/RI model.
1/16

DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067. [Abstract]

Customer Validation
DB2313 (0.3 mg; i.p.; once every 3 d) downregulated IL-9 expression and the proportions of Th9 cells in the spleen and PBMCs of collagen-induced arthritis (CIA) mice.
1/16

DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067. [Abstract]

Customer Validation
PU.1 inhibitor DB2313 (0.3 mg; i.p.; once every 3 d) suppressed IL-9 release from Th9 cells of collagen-induced arthritis (CIA) mice.
1/16

DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067. [Abstract]

Customer Validation
Effect of PU.1 inhibitor DB2313 (0.3 mg; i.p.; once every 3 d) on joint neovascularization in collagen-induced arthritis (CIA) mice.

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DB2313 tetrahydrochloride

Publications Citing Use of MedChemExpress (MCE) DB2313 tetrahydrochloride

Biological Activity

Chemical Information

Publications (7)

Purity & Documentation

References

Calculators

Help & FAQs

DB2313 tetrahydrochloride Related Classifications

HY-124629A Related Classifications