1. GPCR/G Protein
    Neuronal Signaling
    Apoptosis
  2. Opioid Receptor
    Apoptosis
  3. Noscapine

Noscapine (Synonyms: (S,R)-Noscapine)

Cat. No.: HY-13716 Purity: 97.80%
Handling Instructions

Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can crosse the blood-brain barrier.

For research use only. We do not sell to patients.

Noscapine Chemical Structure

Noscapine Chemical Structure

CAS No. : 128-62-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can crosse the blood-brain barrier[1][2][3][4][5].

IC50 & Target

Sigma opioid receptors[4] Bradykinin[5] Apoptosis[1]

In Vitro

Noscapine (0-1000 μM; 0-96 hours; rat C6 glioma cells) treatment inhibits cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. Noscapine inhibits the viability of rat C6 glioma cells with an IC50 of 250 μM at 72 hours[1].
Noscapine exposure causes abnormal S-phase reentry, increases mitotic arrest and results in excessive DNA accumulation[1].
Cylindromatosis increases the ability of noscapine to induce mitotic arrest and apoptosis. Cylindromatosis enhances the effect of noscapine on microtubule polymerization and promotes noscapine binding to microtubules[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Rat C6 glioma cells
Concentration: 0 μM, 0.1 μM, 1 μM, 2 μM, 10 μM, 50 μM, 100 μM, 1000 μM
Incubation Time: 0 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours
Result: Inhibited cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner.
In Vivo

Noscapine (300 mg/kg; oral gavage; daily; for 15 days; athymic female mice) treatment reduces tumor growth in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic female mice (nu/nu) (8-week-old) injected with rat C6 glioma cells[1]
Dosage: 300 mg/kg
Administration: Oral gavage; daily; for 15 days
Result: Revealed a significant reduction of tumor volume.
Clinical Trial
Molecular Weight

413.42

Formula

C₂₂H₂₃NO₇

CAS No.

128-62-1

SMILES

O=C1O[[email protected]]([[email protected]@H]2N(C)CCC3=C2C(OC)=C(OCO4)C4=C3)C5=C1C(OC)=C(OC)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (72.57 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4188 mL 12.0942 mL 24.1885 mL
5 mM 0.4838 mL 2.4188 mL 4.8377 mL
10 mM 0.2419 mL 1.2094 mL 2.4188 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.05 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.05 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Noscapine(S,R)-NoscapineOpioid ReceptorApoptosisAntitussiveoralphthalideisoquinolinealkaloidcylindromatosismitoticarrestmicrotubulesanticancerneuroprotectiveanti-inflammatoryInhibitorinhibitorinhibit

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