1. GPCR/G Protein
    Neuronal Signaling
    Apoptosis
  2. Opioid Receptor
    Apoptosis
  3. Noscapine hydrochloride

Noscapine hydrochloride (Synonyms: (S,R)-Noscapine hydrochloride)

Cat. No.: HY-13716A
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Noscapine hydrochloride ((S,R)-Noscapine hydrochloride) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine hydrochloride exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine hydrochloride disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine hydrochloride possesses anticancer, neuroprotective, anti-inflammatory activities, and can crosse the blood-brain barrier.

For research use only. We do not sell to patients.

Noscapine hydrochloride Chemical Structure

Noscapine hydrochloride Chemical Structure

CAS No. : 912-60-7

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Description

Noscapine hydrochloride ((S,R)-Noscapine hydrochloride) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine hydrochloride exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine hydrochloride disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine hydrochloride possesses anticancer, neuroprotective, anti-inflammatory activities, and can crosse the blood-brain barrier[1][2][3][4][5].

IC50 & Target

Sigma opioid receptors[4] Bradykinin[5] Apoptosis[1]

In Vitro

Noscapine (0-1000 μM; 0-96 hours; rat C6 glioma cells) treatment inhibits cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. Noscapine inhibits the viability of rat C6 glioma cells with an IC50 of 250 μM at 72 hours[1].
Noscapine exposure causes abnormal S-phase reentry, increases mitotic arrest and results in excessive DNA accumulation[1].
Cylindromatosis increases the ability of noscapine to induce mitotic arrest and apoptosis. Cylindromatosis enhances the effect of noscapine on microtubule polymerization and promotes noscapine binding to microtubules[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Rat C6 glioma cells
Concentration: 0 μM, 0.1 μM, 1 μM, 2 μM, 10 μM, 50 μM, 100 μM, 1000 μM
Incubation Time: 0 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours
Result: Inhibited cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner.
In Vivo

Noscapine (300 mg/kg; oral gavage; daily; for 15 days; athymic female mice) treatment reduces tumor growth in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic female mice (nu/nu) (8-week-old) injected with rat C6 glioma cells[1]
Dosage: 300 mg/kg
Administration: Oral gavage; daily; for 15 days
Result: Revealed a significant reduction of tumor volume.
Clinical Trial
Molecular Weight

449.88

Formula

C₂₂H₂₄ClNO₇

CAS No.

912-60-7

SMILES

O=C1O[[email protected]]([[email protected]@H]2N(C)CCC3=C2C(OC)=C(OCO4)C4=C3)C5=C1C(OC)=C(OC)C=C5.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Noscapine(S,R)-NoscapineOpioid ReceptorApoptosisAntitussiveoralphthalideisoquinolinealkaloidcylindromatosismitoticarrestmicrotubulesanticancerneuroprotectiveanti-inflammatoryInhibitorinhibitorinhibit

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Product Name:
Noscapine hydrochloride
Cat. No.:
HY-13716A
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