Trenimon 

Trenimon is a compound with anti-cancer effects. Trenimon shows mutagenic actions in many species by inducing point and chromosomal mutations, sister-chromatid exchanges, recombination phenomena and phage induction. Trenimon can be used for the research of cancer^[1][2][3][4].

Trenimon (0.17 mM) penetrates readily into mouse lymphoma cells in vitro^[1].
Trenimon (0.17 nM; 5 min-16 h) time-denpendently reduces the priming activity of DNA^[2].
Trenimon (1 nM-10 μM; 10-20 min) leds HeLa cells death after 2 weeks with a dose of 10 μM and dose-dependently suppresses mitosis in cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trenimon (0.25 mg/kg; i.p. once) rapidly depresseas of the cellular elements of the peripheral blood (granulocytes, lymphocytes, reticulocytes, platelets and erythrocytes), and reduces the cell number of bone marrow^[4].
Trenimon (0.03 mg/kg; i.v. once per week for 52 weeks) shows an cancerogenic effect in vivo^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

231.25

C₁₂H₁₃N₃O₂

68-76-8

O=C1C(N2CC2)=C(N3CC3)C(C(N4CC4)=C1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Linford JH. 2,3,5-Tris-ethylenimino-1,4-benzoquinone (Trenimon): some chemical and biological properties. Chem Biol Interact. 1973 Mar;6(3):149-68.  [Content Brief]

  [2]. GRUNICKE H, et al. THE EFFECTS OF THE ALKYLATING CYTOSTATIC AGENT, 2,3,5-TRISETHYLENEIMINO-BENZOQUINONE-1,4(TRENIMON), ON THE PRIMING ABILITY OF DNA FROM MOUSE-ASCITES-TUMOR CELLS IN THE RNA-POLYMERASE-SYSTEM. Biochem Biophys Res Commun. 1965 Feb 3;18:319  [Content Brief]

  [3]. Wegehaupt S, Sehrbundt HJ. Cytologische Untersuchungen an HeLa-Zellen nach kurzfristigen 2,3,5-Trisathyleniminobenzochinon-1,4-Gaben (Trenimon-R) [Cytologic studies on HeLa cells following short-spaced doses of 2,3,5-trisethyleniminobenzoquinone-1,4 (Tren  [Content Brief]

  [4]. Obe G, Beek B. Trenimon: biochemical, physiological and genetic effects on cells and organisms. Mutat Res. 1979 Mar;65(1):21-70.  [Content Brief]