Tyrosine kinase-IN-6
Tyrosine kinase-IN-6 is a potent and promising RON splice variants inhibitor with anti-cancer and o?antineoplastic effects.
For research use only. We do not sell to patients.
- CAS No.: 2377507-01-0
- Formula: C37H31F2N5O5S
- Molecular Weight:695.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Tyrosine kinase-IN-6 is a potent and promising RON splice variants inhibitor with anti-cancer and o?antineoplastic effects[1].
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| ASPC1 | GI50 |
0.46 μM
Compound: 15f
|
Antiproliferative activity against human ASPC1 cells harbouring KRAS G12D mutant and RON delta 165 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human ASPC1 cells harbouring KRAS G12D mutant and RON delta 165 assessed as cell growth inhibition measured after 72 hrs by MTS assay
|
[PMID: 37736180] |
| CAPAN-1 | GI50 |
0.55 μM
Compound: 15f
|
Antiproliferative activity against human CAPAN-1 cells harbouring KRAS G12V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human CAPAN-1 cells harbouring KRAS G12V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
|
[PMID: 37736180] |
| HCT-15 | GI50 |
0.29 μM
Compound: 15f
|
Antiproliferative activity against human HCT-15 cells harbouring KRAS G13D mutant and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human HCT-15 cells harbouring KRAS G13D mutant and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
|
[PMID: 37736180] |
| HT-29 | GI50 |
0.609 μM
Compound: 15f
|
Antiproliferative activity against human HT-29 cells harbouring wild-type KRAS and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human HT-29 cells harbouring wild-type KRAS and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
|
[PMID: 37736180] |
| KM12C | GI50 |
0.007 μM
Compound: 15f
|
Antiproliferative activity against human KM12-C cells harbouring wild-type KRAS and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human KM12-C cells harbouring wild-type KRAS and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
|
[PMID: 37736180] |
| LS-411N | GI50 |
1.01 μM
Compound: 15f
|
Antiproliferative activity against human LS-411N cells harbouring wild-type KRAS and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human LS-411N cells harbouring wild-type KRAS and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
|
[PMID: 37736180] |
| MIA PaCa-2 | GI50 |
0.63 μM
Compound: 15f
|
Antiproliferative activity against human MIA PaCa-2 cells harbouring KRAS G12C mutant and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human MIA PaCa-2 cells harbouring KRAS G12C mutant and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
|
[PMID: 37736180] |
| PANC-03-27 | GI50 |
7.34 μM
Compound: 15f
|
Antiproliferative activity against human Panc 03.27 cells harbouring KRAS G12V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human Panc 03.27 cells harbouring KRAS G12V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
|
[PMID: 37736180] |
| PANC-1 | GI50 |
2.4 μM
Compound: 15f
|
Antiproliferative activity against human PANC-1 cells harbouring KRAS G12D mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human PANC-1 cells harbouring KRAS G12D mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
|
[PMID: 37736180] |
| SW1417 | GI50 |
0.32 μM
Compound: 15f
|
Antiproliferative activity against human SW1417 cells harbouring wild-type KRAS and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human SW1417 cells harbouring wild-type KRAS and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
|
[PMID: 37736180] |
| SW480 | GI50 |
0.34 μM
Compound: 15f
|
Antiproliferative activity against human SW480 cells harbouring KRAS G12V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human SW480 cells harbouring KRAS G12V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
|
[PMID: 37736180] |
| SW-620 | GI50 |
0.32 μM
Compound: 15f
|
Antiproliferative activity against human SW620 cells harbouring KRAS G12 V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human SW620 cells harbouring KRAS G12 V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
|
[PMID: 37736180] |
Chemical Information
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CAS No. 2377507-01-0
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Molecular Weight 695.73
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Formula C37H31F2N5O5S
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SMILES
O=C(C1=C(OCC)C=CN(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C5C(C=C(C6=NC=C(CN7CCOCC7)C=C6)S5)=NC=C4)C(F)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
References
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Tyrosine kinase-IN-6 Related Classifications
HY-155812 Related Classifications
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