2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis Caspase PARP Survivin
  4. Acrofolione A

Acrofolione A is an acetophenone dimer isolated from Acronychia pendunculata with anticancer effects. Acrofolione A induces G0/G1 phase cell cycle arrest and apoptosis in human NALM-6 pre-B cell leukaemia cells. Acrofolione A can be used for leukaemia research.

For research use only. We do not sell to patients.

Acrofolione A

Acrofolione A Chemical Structure

CAS No. : 820975-61-9

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Acrofolione A Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

Acrofolione A is an acetophenone dimer isolated from Acronychia pendunculata with anticancer effects. Acrofolione A induces G0/G1 phase cell cycle arrest and apoptosis in human NALM-6 pre-B cell leukaemia cells. Acrofolione A can be used for leukaemia research[1].

In Vitro

Acrofolione A (48 h) suppresses the growth of NALM-6, K562 and HPB-ALL cells with IC50 values of 16.7, 17.9, and 10.1 μM, respectively[1].
Acrofolione A (10-20 μM, 6-48 h) induces G0/G1-phase cell cycle arrest and promotes apoptosis in NALM-6 cells, as demonstrated by decreased mitochondrial membrane potential, elevated caspase 3/7 activity, increased levels of cleaved PARP and cleaved caspase-3/7, and reduced expression of survivin protein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acrofolione A Related Antibodies
Molecular Weight

570.67

Formula

C32H42O9
CAS No.
SMILES

CC(C)CC(C1=C(C(C/C=C(C)\C)=C(C(C(C)=O)=C1O)OC)O)C2=C3C(CC(O3)C(C)(O)C)=C(C(C(C)=O)=C2O)O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Acrofolione A Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acrofolione A820975-61-9ApoptosisCaspasePARPSurvivinpoly ADP ribose polymeraseacetophenone dimerhuman NALM-6 pre-B cell leukaemia cellsleukaemiaK562HPB-ALLInhibitorinhibitorinhibit

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