Acrofolione A
Acrofolione A is an acetophenone dimer isolated from Acronychia pendunculata with anticancer effects. Acrofolione A induces G0/G1 phase cell cycle arrest and apoptosis in human NALM-6 pre-B cell leukaemia cells. Acrofolione A can be used for leukaemia research.
For research use only. We do not sell to patients.
- CAS No.: 820975-61-9
- Formula: C32H42O9
- Molecular Weight:570.67
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Caspase Isoforms
More
Biological Activity
Acrofolione A (48 h) suppresses the growth of NALM-6, K562 and HPB-ALL cells with IC50 values of 16.7, 17.9, and 10.1 μM, respectively[1].
Acrofolione A (10-20 μM, 6-48 h) induces G0/G1-phase cell cycle arrest and promotes apoptosis in NALM-6 cells, as demonstrated by decreased mitochondrial membrane potential, elevated caspase 3/7 activity, increased levels of cleaved PARP and cleaved caspase-3/7, and reduced expression of survivin protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 820975-61-9
-
Molecular Weight 570.67
-
Formula C32H42O9
-
SMILES
CC(C)CC(C1=C(C(C/C=C(C)\C)=C(C(C(C)=O)=C1O)OC)O)C2=C3C(CC(O3)C(C)(O)C)=C(C(C(C)=O)=C2O)O
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz