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Cat. No.: HY-178998

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5-HT7R antagonist 5

5-HT7R antagonist 5 (Compound (R)-4) is a 5-HT_7AR antagonist, with a K_i of 46.4 nM. 5-HT7R antagonist 5 shows anticancer effects against prostate cancer.

For research use only. We do not sell to patients.

Formula: C₁₈H₁₇N₃S
Molecular Weight:307.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

5-HT7R antagonist 5 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

5-HT7R antagonist 5 (Compound (R)-4) is a 5-HT_7AR antagonist, with a K_i of 46.4 nM. 5-HT7R antagonist 5 shows anticancer effects against prostate cancer^[1].

IC₅₀ & Target

K_i: 46.4 nM (5-HT_7AR)^[1]

All 5-HT Receptor Isoforms :

Chemical Information

Molecular Weight 307.41
Formula C₁₈H₁₇N₃S
SMILES

CN1[C@@]2([H])C3=C(C(C(SC(N)=N4)=C4C=C5)=C5C2)C=CC=C3CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Okpattah D, et al. Synthesis and evaluation of aporphinoid 5-HT7AR ligands as inhibitors of PC3 prostate cancer cell growth. Bioorg Med Chem Lett. 2025 Dec 1;128:130328. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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5-HT7R antagonist 5

All 5-HT Receptor Isoforms