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Cat. No.: HY-106109

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FK 973

FK 973 is a dihydrobenzoxazine anticancer agent. FK 973 selectively inhibits DNA synthesis and can form DNA cross-links through cytoplasmic activation. FK 973 exhibits significant antitumor activity in various animal tumor models and human tumor xenografts, with relatively weak myelosuppressive effects. FK 973 is sensitive to neural tumor cells. FK 973 can be used for DNA-targeted antitumor research.

For research use only. We do not sell to patients.

CAS No.: 114580-45-9
Formula: C₂₀H₂₁N₃O₉
Molecular Weight:447.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

FK 973 Chemical Structure

CAS No.: 114580-45-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

FK 973 (48 h) inhibits cancer cells growth including human glioblastoma (ONS-6, 12, 23, and ONS-12/ACNU), human medulloblastoma (ONS-76, 81), human neuroblastoma (ST), murine glioblastoma (RSV-M glioma) and L1210 cells with IC₅₀s of 0.06-5 μg/mL^[1]^[2].
FK 973 (0-30 μM, 1 h) forms DNA-DNA interchain cross-links and DNA-protein cross-links without causing DNA single-strand breaks in L1210 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FK 973 (intrathecal, i.t.) significantly prolongs the survival of mice in a meningioma model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 114580-45-9
Molecular Weight 447.40
Formula C₂₀H₂₁N₃O₉
SMILES

CC(O[C@]12[C@@H]3[C@H](C[N@@](C4=CC(C=O)=CC(OC(C)=O)=C4[C@@H]2COC(N)=O)O1)N3C(C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shimizu K, et al. [Antitumor efficacy of FK 973 on malignant glioma cells]. Gan To Kagaku Ryoho. 1989 Jul;16(7):2367-72. Japanese. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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FK 973

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

FK 973 Related Classifications

HY-106109 Related Classifications