Zoledronic acid monohydrate (Standard)
Zoledronic acid (monohydrate) (Standard) is the analytical standard of Zoledronic acid (monohydrate). This product is intended for research and analytical applications. Zoledronic acid monohydrate (Zoledronate monohydrate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic acid monohydrate inhibits the differentiation and apoptosis of osteoclasts. Zoledronic acid monohydrate also has anti-cancer effects.
For research use only. We do not sell to patients.
- CAS No.: 165800-06-6
- Formula: C5H12N2O8P2
- Molecular Weight:290.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 165800-06-6
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Molecular Weight 290.10
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Formula C5H12N2O8P2
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SMILES
OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1.[H]O[H]
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Synonyms
Zoledronate monohydrate (Standard); CGP 42446 monohydrate (Standard); CGP42446A monohydrate (Standard); ZOL 446 monohydrate (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lianwei Wang, et al. Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review. BMC Cancer. 2020; 20: 1059. [Content Brief]
[2]. Hyung Joon Kim, et al. Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis. Int J Mol Sci. 2019 Mar; 20(6): 1467. [Content Brief]
[3]. Xiao-Lin Huang, et al. Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways. Int J Mol Med. 2019 Aug;44(2):582-592. [Content Brief]
[4]. XIN HUANG, et al. Dose-dependent inhibitory effects of zoledronic acid on osteoblast viability and function in vitro. Mol Med Rep. 2016 Jan; 13(1): 613-622. [Content Brief]
[5]. Samantha Pozzi, et al. High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical properties. Clin Cancer Res. 2009 Sep 15;15(18):5829-39. [Content Brief]
[6]. Shea GKH, et al. Oral Zoledronic acid bisphosphonate for the treatment of chronic low back pain with associated Modic changes: A pilot randomized controlled trial. J Orthop Res. 2022 Feb 23. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
- Zoledronic acid monohydrate (Standard)
- 165800-06-6
- Zoledronate monohydrate (Standard)
- CGP 42446 monohydrate (Standard)
- CGP42446A monohydrate (Standard)
- ZOL 446 monohydrate (Standard)
- Reference Standards
- Apoptosis
- Autophagy
- Bacterial
- bisphosphonate
- anti-resorptive
- osteoclast
- activity
- osteoporosis
- anti-cancer
- Inhibitor
- inhibitor
- inhibit