1. Autophagy
  2. Autophagy
  3. Zoledronic acid monohydrate

Zoledronic acid monohydrate (Synonyms: Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate)

Cat. No.: HY-13777A Purity: >99.0%
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Zoledronic acid monohydrate is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.

For research use only. We do not sell to patients.

Zoledronic acid monohydrate Chemical Structure

Zoledronic acid monohydrate Chemical Structure

CAS No. : 165800-06-6

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10 mM * 1 mL in Water USD 106 In-stock
Estimated Time of Arrival: December 31
50 mg USD 96 In-stock
Estimated Time of Arrival: December 31
100 mg USD 156 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Zoledronic acid monohydrate:

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Description

Zoledronic acid monohydrate is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.

In Vitro

Zoledronic acid monohydrate induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2].

Clinical Trial
Molecular Weight

290.10

Formula

C₅H₁₂N₂O₈P₂

CAS No.

165800-06-6

SMILES

OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1.[H]O[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 14.29 mg/mL (49.26 mM; ultrasonic and adjust pH to 8 with NaOH)

H2O : 1 mg/mL (3.45 mM; Need ultrasonic)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4471 mL 17.2354 mL 34.4709 mL
5 mM 0.6894 mL 3.4471 mL 6.8942 mL
10 mM 0.3447 mL 1.7235 mL 3.4471 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Zoledronic acidZoledronateCGP 42446CGP42446AZOL 446CGP42446CGP-42446ZOL446ZOL-446AutophagyInhibitorinhibitorinhibit

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Product name:
Zoledronic acid monohydrate
Cat. No.:
HY-13777A
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