2. Apoptosis Autophagy Anti-infection
  3. Apoptosis Autophagy Bacterial
  4. Zoledronic acid disodium tetrahydrate

Zoledronic acid disodium tetrahydrate  (Synonyms: Zoledronate disodium tetrahydrate; CGP 42446 disodium tetrahydrate; CGP42446A disodium tetrahydrate; ZOL 446 disodium tetrahydrate)

Cat. No.: HY-13777B
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Zoledronic Acid (Zoledronate) disodium tetrahydrate is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid disodium tetrahydrate inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid disodium tetrahydrate also has anti-cancer effects.

For research use only. We do not sell to patients.

CAS No. : 165800-07-7

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Zoledronic acid disodium tetrahydrate Related Antibodies

Top Publications Citing Use of Products

    Zoledronic acid disodium tetrahydrate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2025 Jan 30:e184468.  [Abstract]

    Serum creatinine, urea nitrogen, and uric acid levels in CKD mice or sham-operated mice (Zoledronic Acid: i.p., 20/100 μg/kg, once per day, 4 weeks).

    Zoledronic acid disodium tetrahydrate purchased from MedChemExpress. Usage Cited in: Commun Biol. 2024 Nov 9;7(1):1476.  [Abstract]

    Representative images and statistical graph of transwell assays from the indicated groups after treatment with ZOL at different concentrations (0, 10 and 20 μM) in UM-UC-3 cells and T24 cells for 48 h.

    Zoledronic acid disodium tetrahydrate purchased from MedChemExpress. Usage Cited in: Commun Biol. 2024 Nov 9;7(1):1476.  [Abstract]

    An MTT assay was performed to detect changes in the proliferation of BLCA cells (UM-UC-3, T24 and 5637) after treatment with different concentrations (0, 1, 2, 5, 10, 20, 40, 60 and 80 μM) of ZOL for 48 h.

    Zoledronic acid disodium tetrahydrate purchased from MedChemExpress. Usage Cited in: Commun Biol. 2024 Nov 9;7(1):1476.  [Abstract]

    Western blot analyses of EMT-related proteins in ZOL-treated ((0, 10 and 20 μM, 48 h) UM-UC-3, T24 and 5637 cells. GAPDH was used as the loading control.

    Zoledronic acid disodium tetrahydrate purchased from MedChemExpress. Usage Cited in: Commun Biol. 2024 Nov 9;7(1):1476.  [Abstract]

    ZOL (100 μg/kg, intraperitoneally injection, three times a week for 4 weeks). Representative images of H&E-stained mouse lung tissue sections (n = 3)and statistical analysis of the number of metastatic nodules in H&E-stained mouse lung tissue sections.

    Zoledronic acid disodium tetrahydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Mar 21;15(1):2529.  [Abstract]

    Representative TRAP staining images of femur cortical bone and quantification of TRAP positive cell number from PBS or zoledronic acid (100 µg/kg, intraperitoneal injection, once per week for 2 weeks) treated 4-week-old Dmp1Cre-DTAki/wt mice.

    Zoledronic acid disodium tetrahydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Mar 21;15(1):2529.  [Abstract]

    Representative confocal images of femur cortical bone and quantitative result of TCVs from PBS or zoledronic acid (100 µg/kg, intraperitoneal injection, once per week for 2 weeks) treated 4-week-old Dmp1Cre-DTAki/wt mice.

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    Description

    Zoledronic Acid (Zoledronate) disodium tetrahydrate is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid disodium tetrahydrate inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid disodium tetrahydrate also has anti-cancer effects[1].

    In Vitro

    Zoledronic Acid disodium tetrahydrate (0.1-1 µM; 48 hours) increases receptor activator of nuclear factor kB ligand (RANKL) and sclerostin mRNA expressions in osteocyte-like MLO-Y4 cells[2].
    Zoledronic Acid disodium tetrahydrate increases the expression of osteoclastogenesis supporting factor from MLO-Y4 cells[2].
    Zoledronic Acid disodium tetrahydrate enhances the RANKL expression via IL-6/ JAK2/STAT3 pathway in MLO-Y4 cells[2].
    Zoledronic acid disodium tetrahydrate inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways[3].
    Zoledronic Acid disodium tetrahydrate (10-100 µM; 1-7 days) markedly reduces the viability of MC3T3-E1 cells and induces apoptosis in MC3T3-E1 cells[4].
    Zoledronic Acid disodium tetrahydrate (10-100 µM; 4 days) inhibits cell viability due to the induction of apoptosis[4].
    Zoledronic Acid disodium tetrahydrate exerts inhibitory effects on the differentiation and maturation of MC3T3-E1 cells at concentrations <1 µM[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Zoledronic acid disodium tetrahydrate Related Antibodies

    Cell Viability Assay[4]

    Cell Line: MC3T3-E1 cells
    Concentration: 0.01 µM , 0.1 µM, 1 µM, 10 µM, 100 µM
    Incubation Time: 1 day, 3 days, 5 days, 7 days
    Result: Reduced cells viability at 10 µM and 100 µM.

    Apoptosis Analysis[4]

    Cell Line: MC3T3-E1 cells
    Concentration: 0.01 µM , 0.1 µM, 1 µM, 10 µM, 100 µM
    Incubation Time: 1 days, 4 days, 7 days
    Result: Increased the number of early apoptotic cells and late apoptotic or necrotic cells at dose-dependent and time-dependent (high concentrations).

    Western Blot Analysis[4]

    Cell Line: MC3T3-E1 cells
    Concentration: 0.01 µM , 0.1 µM, 1 µM, 10 µM, 100 µM
    Incubation Time: 4 days
    Result: Down-regulated the protein level of inactive caspase-3 and up-regulated the protein level of active caspase-3 at the concentrations of 10 and 100 µM.
    In Vivo

    Zoledronic Acid disodium tetrahydrate (0.05 mg/kg; i.p.; weekly; for 3 weeks) increases bone mineral density and content[5].
    Zoledronic Acid disodium tetrahydrate (0.5-1 mg/kg; i.p.; weekly; for 3 weeks) inhibits both osteoclast and osteoblasts function and bone remodeling in vivo interfering with bone mechanical properties[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Five-week-old C57BL6 mice[5]
    Dosage: 0.05 mg/kg, 0.5 mg/kg, 1 mg/kg
    Administration: Intraperitoneal injection, weekly, for 3 weeks
    Result: Inhibited both osteoclast and osteoblasts function and bone remodeling at 0.5 mg/kg and 1 mg/kg.
    Molecular Weight

    390.13

    Formula

    C5H18N2Na2O11P2
    CAS No.
    SMILES

    OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[Na].[Na]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Zoledronic acid disodium tetrahydrate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Zoledronic acid disodium tetrahydrate165800-07-7Zoledronate disodium tetrahydrate CGP 42446 disodium tetrahydrate CGP42446A disodium tetrahydrate ZOL 446 disodium tetrahydrateApoptosisAutophagyBacterialMC3T3-E1 cellsbisphosphonateanti-resorptiveosteoclastosteoporosisanti-cancerbone resorptionlow back painInhibitorinhibitorinhibit

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