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Cat. No.: HY-N7423A

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(E)-Methyl isoferulate

(Synonyms: (E)-Isoferulic acid methyl ester)

(E)-Methyl isoferulate ((E)-Isoferulic acid methyl ester) is a derivative of Cinnamic acid (HY-N0610A) and NO inhibitor, with an IC₅₀ > 100 μM against nitric oxide production. (E)-Methyl isoferulate is isolable from the solid cultures of the edible mushroom Neolentinus lepideus. (E)-Methyl isoferulate exerts mild anticancer effects against liver cancer and leukemia.

For research use only. We do not sell to patients.

CAS No.: 97966-29-5
Formula: C₁₁H₁₂O₄
Molecular Weight:208.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(E)-Methyl isoferulate Chemical Structure

CAS No.: 97966-29-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Fungal Metabolite

All NO Synthase Isoforms :

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	30 μg/mL Compound: 4i	Inhibitory concentration required against A 431 human epidermoid carcinoma cell line Inhibitory concentration required against A 431 human epidermoid carcinoma cell line	[PMID: 11354370]

In Vitro

(E)-Methyl isoferulate (Compound 8) (3.125-100 μM; 24 h) weakly inhibits LPS-induced nitric oxide production in RAW 264.7 cells, with an IC₅₀ greater than 100 μM, and shows no cytotoxicity to these cells at 100 μM^[1].
(E)-Methyl isoferulate (72 h) displays weak cytotoxicity against HepG2 and K562 cells, with an IC₅₀ greater than 200 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 97966-29-5
Molecular Weight 208.21
Formula C₁₁H₁₂O₄
SMILES

COC(/C=C/C1=CC(O)=C(C=C1)OC)=O
Synonyms

(E)-Isoferulic acid methyl ester
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
- Phenols
- Monophenols
Initial Source
- Microorganisms
Neolentinus lepideus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li Y, et al. A new benzoquinone and a new benzofuran from the edible mushroom Neolentinus lepideus and their inhibitory activity in NO production inhibition assay. Food Chem. 2013;141(3):1614-1618. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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(E)-Methyl isoferulate

All NO Synthase Isoforms

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(E)-Methyl isoferulate Related Classifications

HY-N7423A Related Classifications