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Cat. No.: HY-152099

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Antiproliferative agent-19

Antiproliferative agent-19 (compound 4a) is an anti-cancer agent that exerts anti-proliferative effects on lung cancer cells by inducing apoptosis. antiproliferative agent-19 also induces cell cycle arrest in the G2/M phase.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₃NO
Molecular Weight:365.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Antiproliferative agent-19 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Antiproliferative agent-19 (0-50 µM; 72 h) significantly inhibits the viability of human nonsmall cell lung cancer and colon cancer cells^[1].
Antiproliferative agent-19 (11.33 µM; 24, 48, and 72 h) induces sub‑G1‑phase cell cycle arrest in A549 cells^[1].
Antiproliferative agent-19 (11.33 µM; 6, 24 and 48 h) induces apoptosis via intrinsic and extrinsic pathways in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HCT-116 and A549 cells
Concentration:

0-50 µM
Incubation Time:

72 h
Result:

Inhibited the growth of HCT-116 and A549 cells with IC₅₀ values of 12.18 and 11.33 µM, respectively.

Cell Cycle Analysis^[1]

Cell Line:

A549 cells
Concentration:

11.33 µM
Incubation Time:

24, 48, and 72 h
Result:

Increased cells of G2 phase significantly from 3.2% (DMSO-treated cells) to 15.5% and 33.8% (cells treated with the compound for 24 and 48 h, respectively).

Apoptosis Analysis^[1]

Cell Line:

A549 cells
Concentration:

11.33 µM
Incubation Time:

6, 24 and 48 h
Result:

Induced caspase-dependent cell death.

Chemical Information

Molecular Weight 365.47
Formula C₂₆H₂₃NO
SMILES

O=C1NC2=C(CCCC2)C(C3=CC=CC=C3)=C1CC4=C5C=CC=CC5=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ryczkowska M, et al. Tetrahydroquinolinone derivatives exert antiproliferative effect on lung cancer cells through apoptosis induction. Sci Rep. 2022 Nov 9;12(1):19076. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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