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Cat. No.: HY-N19850

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Mammea B/BD

Mammea B/BD is an anticancer antioxidant that can be isolated from the seeds of Mammea americana. Mammea B/BD exhibits antiproliferative effects on colon cancer cells. Mammea B/BD scavenges DPPH free radicals. Mammea B/BD can be used in colon cancer research.

For research use only. We do not sell to patients.

CAS No.: 98216-05-8
Formula: C₂₁H₂₆O₅
Molecular Weight:358.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mammea B/BD Chemical Structure

CAS No.: 98216-05-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Mammea B/BD (Compound 13) (72 h) potently inhibits the viability of SW-480, HT-29 and HCT-116 human colon cancer cells, with IC₅₀ values of 15.4 μM, 16.8 μM and 15.9 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 98216-05-8
Molecular Weight 358.43
Formula C₂₁H₂₆O₅
SMILES

O=C1OC2=C(C(CCC)=C1)C(O)=C(C/C=C(C)\C)C(O)=C2C(C(C)C)=O
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang H, et al. Antioxidant and cytotoxic isoprenylated coumarins from Mammea americana. Planta Med. 2005;71(9):852-860. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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