Bersanlimab
Based on 1 Customer Validation
Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 1987854-08-9
- Molecular Weight:144.22 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Human IgG1 lambda2
Human
ICAM1/CD54
BI-505 (1 ng/mL-1000 μg/mL) dose-dependently induces programmed cell death (PCD) in ICAM-1-expressing Ramos, Raji, and Daudi lymphoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:SCID mice injected with ARH-77 cells[1]
-
Dosage:20 mg/kg
-
Administration:i.p.; twice-weekly; for 21 days
-
Result:Significantly reduced tumor growth and prolonged animal survival.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Human IgG1 lambda2
ELISA, FACS, Functional assay
-
Immobilized ICAM-1/CD54 Protein, Human (HEK293, His, HY-P72621) can bind Bersanlimab. The EC50 for this effect is 0.4293 ng/mL. -
Flow Cytometry analysis of Raji cells labelling ICAM1/CD54 (red) with Bersanlimab (anti-ICAM1/CD54) (HY-P99473). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 lambda2 (HY-P990096). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
-
CAS No. 1987854-08-9
-
Appearance Liquid
-
Molecular Weight 144.22 kDa
-
Color Colorless to light yellow
-
SMILES
[Bersanlimab]
-
Synonyms
BI-505
-
Shipping
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (256 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bersanlimab Related Classifications
HY-P99473 Related Classifications
Powered by Bioz