Bersanlimab
Based on 1 Customer Validation
Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects.
For research use only. We do not sell to patients.
- Purity : 99.85%
- CAS No.: 1987854-08-9
- Molecular Weight:144.22 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 lambda2
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
ICAM1/CD54
In Vitro
BI-505 (1 ng/mL-1000 μg/mL) dose-dependently induces programmed cell death (PCD) in ICAM-1-expressing Ramos, Raji, and Daudi lymphoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice injected with ARH-77 cells[1]
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Dosage:20 mg/kg
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Administration:i.p.; twice-weekly; for 21 days
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Result:Significantly reduced tumor growth and prolonged animal survival.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 lambda2
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized ICAM-1/CD54 Protein, Human (HEK293, His, HY-P72621) can bind Bersanlimab. The EC50 for this effect is 0.4293 ng/mL. -
Flow Cytometry analysis of Raji cells labelling ICAM1/CD54 (red) with Bersanlimab (anti-ICAM1/CD54) (HY-P99473). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 lambda2 (HY-P990096). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 1987854-08-9
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Appearance Liquid
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Molecular Weight 144.22 kDa
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Color Colorless to light yellow
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SMILES
[Bersanlimab]
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Synonyms
BI-505
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)