2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Emindole SB

Emindole SB is an anticancer agent. Emindole SB can be isolated from Penicillium species. Emindole SB exerts anticancer effects against ovarian cancer, breast cancer and lymphoma. Emindole SB shows no toxicity to Caenorhabditis elegans. Emindole SB can be used in studies related to ovarian cancer, lymphoma and breast cancer.

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Emindole SB

Emindole SB Chemical Structure

CAS No. : 112900-04-6

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Emindole SB Related Antibodies

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Description

Emindole SB is an anticancer agent. Emindole SB can be isolated from Penicillium species. Emindole SB exerts anticancer effects against ovarian cancer, breast cancer and lymphoma. Emindole SB shows no toxicity to Caenorhabditis elegans. Emindole SB can be used in studies related to ovarian cancer, lymphoma and breast cancer[1][2].

IC50 & Target[1]

Fungal Metabolite

 

In Vitro

Emindole SB (at increasing concentrations; 72 h) inhibits the viability of mouse lymphoma L5178Y cells, with an IC50 of 18.3 μM[1].
Emindole SB (at increasing concentrations; 72 h) inhibits the viability of ovarian cancer A2780 cells, with an IC50 of 8.2 μM and a selectivity index of 5.4 relative to embryonic kidney HEK-293 cells[1].
Emindole SB (at increasing concentrations; 72 h) inhibits the viability of embryonic kidney HEK-293 cells with an IC50 of 44.6 μM[1].
Emindole SB (increasing concentrations; 72 h) exhibits no cytotoxic activity against bladder urothelial carcinoma cell line J82[1].
Emindole SB (72 h) inhibits the proliferation of breast cancer MCF-7 and MDA-MB-231 cells, with an IC50 of 10.1 μM for the former and 21.3 μM for the latter[2].
Emindole SB (multiple treatments; 24 h) inhibits the migration of breast cancer MDA-MB-231 cells, with an IC50 value of 19.0 μM[2].
Emindole SB (7.5-15.0 μM; 24 h) does not inhibit the invasion of breast cancer MDA-MB-231 cells at concentrations of 7.5 μM or 15.0 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Emindole SB Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: murine lymphoma L5178Y cells
Concentration: increasing concentrations
Incubation Time: 72 h
Result: Exhibited cytotoxic activity against L5178Y cells with an IC50 value of 18.3 μM.

Cell Cytotoxicity Assay[1]

Cell Line: human ovarian cancer A2780 cells
Concentration: increasing concentrations
Incubation Time: 72 h
Result: Exhibited pronounced cytotoxic activity against A2780 cells with an IC50 value of 8.2 μM.
Demonstrated a selectivity index (SI) of 5.4 calculated as the IC50 against HEK-293 cells divided by the IC50 against A2780 cells.

Cell Cytotoxicity Assay[1]

Cell Line: human embryonic kidney HEK-293 cells
Concentration: increasing concentrations
Incubation Time: 72 h
Result: Exhibited cytotoxic activity against HEK-293 cells with an IC50 value of 44.6 μM.

Cell Proliferation Assay[2]

Cell Line: human breast cancer MCF-7, MDA-MB-231 cell lines
Concentration: Multiple doses
Incubation Time: 72 h
Result: Inhibited proliferation of MCF-7 cells with an IC50 of 10.1 μM.
Inhibited proliferation of MDA-MB-231 cells with an IC50 of 21.3 μM.

Cell Migration Assay[2]

Cell Line: human breast cancer MDA-MB-231 cell line
Concentration: Multiple doses
Incubation Time: 24 h
Result: Inhibited migration of MDA-MB-231 cells with an IC50 of 19.0 μM.
In Vivo

Emindole SB (1.0 μM; plate-incorporated; continuous exposure from L1 to L4 larval stage) does not inhibit BK channels in Caenorhabditis elegans[2].
Emindole SB (10-50 μM; plate-incorporated; continuous exposure from L1 stage onward) shows no detectable toxicity to Caenorhabditis elegans at exposure concentrations up to 50 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: wild-type N2 Bristol strain (synchronized L1 stage larvae, incubated to L4 larval stage)[2]
Dosage: 1.0 μM
Administration: plate-incorporated; continuous exposure from L1 to L4 larval stage
Result: Exhibited reversal counts comparable to vehicle (DMSO) control, with no statistically significant increase relative to control.
Animal Model: wild-type N2 Bristol strain (synchronized L1 stage larvae, observed over 7 days post-exposure)[2]
Dosage: 10 μM; 50 μM
Administration: plate-incorporated; continuous exposure from L1 stage onward
Result: Showed no generalized effects on nematode viability or reproduction at either concentration.
Molecular Weight

405.63

Formula

C28H39NO
CAS No.
SMILES

C[C@]12C3=C(C[C@@]1(CC[C@@]4([C@]2(C)CC[C@H](O)[C@]4(CCC=C(C)C)C)[H])[H])C=5C(N3)=CC=CC5
Structure Classification
Initial Source

Aspergillus oryzae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Emindole SB Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emindole SB112900-04-6Endogenous MetaboliteBK channelhuman embryonic kidney HEK-293 cellsmurine lymphoma L5178Y cellshuman urothelial bladder cancer J82 cellshuman ovarian cancer A2780 cellslymphomabreast cancerCaenorhabditis elegansovarian cancerhuman breast cancer MCF-7 cellsInhibitorinhibitorinhibit

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