MALT1-IN-8
MALT1-IN-8 is a potent MALT1 protease inhibitor with a IC50 of 2 nM. MALT1-IN-8 inhibits the growth of OCI-LY3 lymphoma cells with an IC50 of 1.16 μM. MALT1-IN-8 has anticancer effects (WO2018165385A1; Compound 8).
For research use only. We do not sell to patients.
- CAS No.: 2244109-29-1
- Formula: C20H15Cl2N7O
- Molecular Weight:440.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
IC50 & Target
IC50: 2 nM (MALT1 protease)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| OCI-Ly3 | EC50 |
0.99 μM
Compound: 15
|
Antiproliferative activity against human OCILY3 cells by cell proliferation assay
Antiproliferative activity against human OCILY3 cells by cell proliferation assay
|
[PMID: 31129051] |
Chemical Information
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CAS No. 2244109-29-1
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Molecular Weight 440.29
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Formula C20H15Cl2N7O
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SMILES
O=C(NC1=CC(Cl)=C(N2N=CC=N2)N=C1)NC3=C(C4CC4)C5=CC(Cl)=CC=C5N=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)