d-(KLAKLAK)2, Proapoptotic Peptide acetate
Based on 1 Customer Validation
d-(KLAKLAK)2, Proapoptotic Peptide acetate is a pro-Apoptotic peptide whose core mechanism of action is to disrupt organelle membranes, especially mitochondrial membranes, thereby inducing apoptosis. d-(KLAKLAK)2, Proapoptotic Peptide acetate activates the activity of caspase 3/7 in cancer cells. Although d-(KLAKLAK)2 Proapoptotic Peptide acetate exhibits very low toxicity to eukaryotic cells extracellularly, it cannot effectively penetrate cell membranes to enter the cytoplasm on its own. d-(KLAKLAK)2, Proapoptotic Peptide acetate must be conjugated with a carrier capable of "homing" and "internalization" to exert its anti-cancer effects.
For research use only. We do not sell to patients.
- Purity : 98.21%
- Formula: C72H139N21O14xC2H4O2
- Molecular Weight:1523.01 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Caspase-3 |
Caspase-7 |
In Vitro
d-(KLAKLAK)2 (0.44 μM) acetate induces mitochondrial swelling in a cell-free system with an ED50 of 0.44 μM[1].
d-(KLAKLAK)2 (0.4 μM) acetate induces mitochondrial membrane potential loss in a cell-free system with an ED50 of 0.4 μM[1].
Cationic liposome-delivered d-(KLAKLAK)2 (co-loaded with G3139) (0.1875-1.5 μM; 24 h) acetate reduces viability of B16(F10) mouse melanoma cells by ~20% at 0.1875 μM and ~40% at 0.375 μM[1].
d-(KLAKLAK)2, Proapoptotic Peptide (24 hours) acetate does not inhibit proliferation of highly metastatic PC-3M-1E8 prostate cancer cells, MKN-45sci gastric cancer cells, or NIH/3T3 fibroblast cells[2].
d-(KLAKLAK)2, Proapoptotic Peptide acetate does not induce apoptosis in highly metastatic PC-3M-1E8 prostate cancer cells or MKN-45sci gastric cancer cells, as it cannot enter the tumor cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 1523.01 (free base)
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Formula C72H139N21O14xC2H4O2
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Color White to off-white
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Sequence
{d-(Lys-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Lys)}-NH2
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Sequence Shortening
{d-(KLAKLAKKLAKLAK)}-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 1 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ko YT, et al. Cationic liposomes loaded with proapoptotic peptide D-(KLAKLAK)(2) and Bcl-2 antisense oligodeoxynucleotide G3139 for enhanced anticancer therapy. Mol Pharm. 2009 May-Jun;6(3):971-7. [Content Brief]
[2]. Ma X, et al. Anti-tumor effects of the peptide TMTP1-GG-D(KLAKLAK)(2) on highly metastatic cancers. PLoS One. 2012;7(9):e42685. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
d-(KLAKLAK)2, Proapoptotic Peptide acetate Related Classifications
HY-P10370B Related Classifications
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Keywords
- d-(KLAKLAK)2, Proapoptotic Peptide
- Apoptosis
- Caspase
- eukaryotic plasma membranes
- highly metastatic prostate cancer
- mitochondrial-dependent apoptosis
- cancer cells
- melanoma
- anionic prokaryotic cytoplasmic membranes
- highly metastatic gastric cancer
- eukaryotic mitochondrial membranes
- caspase 3/7
- B16(F10) mouse melanoma cells
- Inhibitor
- inhibitor
- inhibit