2. Autophagy
  3. Autophagy
  4. UNBS3157

UNBS3157 is a naphthalimide derivative that shows potent anticancer effect. UNBS3157 induces autophagy and senescence in cancer cells. UNBS3157 displays significant antitumor effects in vivo. UNBS3157 can be used for leukemia, mammary adenocarcinoma, non-small cell lung cancer (NSCLC) and pancreatic cancer research.

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UNBS3157

UNBS3157 Chemical Structure

CAS No. : 868962-26-9

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UNBS3157 Related Antibodies

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Description

UNBS3157 is a naphthalimide derivative that shows potent anticancer effect. UNBS3157 induces autophagy and senescence in cancer cells. UNBS3157 displays significant antitumor effects in vivo. UNBS3157 can be used for leukemia, mammary adenocarcinoma, non-small cell lung cancer (NSCLC) and pancreatic cancer research[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.9 μM
Compound: 17, UNBS3157
Antiproliferative activity against A549 cells after 72 hrs by MTT assay
Antiproliferative activity against A549 cells after 72 hrs by MTT assay
[PMID: 17658777]
HCT-15 IC50
0.9 μM
Compound: 17, UNBS3157
Antiproliferative activity against HCT15 cells after 72 hrs by MTT assay
Antiproliferative activity against HCT15 cells after 72 hrs by MTT assay
[PMID: 17658777]
Hs 683 IC50
0.8 μM
Compound: 17, UNBS3157
Antiproliferative activity against Hs683 cells after 72 hrs by MTT assay
Antiproliferative activity against Hs683 cells after 72 hrs by MTT assay
[PMID: 17658777]
LoVo IC50
0.9 μM
Compound: 17, UNBS3157
Antiproliferative activity against LoVo cells after 72 hrs by MTT assay
Antiproliferative activity against LoVo cells after 72 hrs by MTT assay
[PMID: 17658777]
MCF7 IC50
1.8 μM
Compound: 17, UNBS3157
Antiproliferative activity against MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against MCF7 cells after 72 hrs by MTT assay
[PMID: 17658777]
U-373MG ATCC IC50
0.9 μM
Compound: 17, UNBS3157
Antiproliferative activity against U373MG cells after 72 hrs by MTT assay
Antiproliferative activity against U373MG cells after 72 hrs by MTT assay
[PMID: 17658777]
Molecular Weight

471.72

Formula

C19H17Cl3N4O4
CAS No.
SMILES

O=C(NC(NC1=CC2=CC=CC(C(N(CCN(C)C)C3=O)=O)=C2C3=C1)=O)C(Cl)(Cl)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UNBS3157 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNBS3157868962-26-9UNBS 3157UNBS-3157Autophagynaphthalimide derivativeautophagysenescenceleukemiamammary adenocarcinomapancreaticNSCLCInhibitorinhibitorinhibit

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