1. Apoptosis
  2. Apoptosis
  3. Darinaparsin

Darinaparsin (Synonyms: ZIO-101; S-Dimethylarsino-glutathione)

Cat. No.: HY-14943
Handling Instructions

Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects.

For research use only. We do not sell to patients.

Darinaparsin Chemical Structure

Darinaparsin Chemical Structure

CAS No. : 69819-86-9

Size Stock
5 mg Get quote
10 mg Get quote

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects[1].

In Vitro

Darinaparsin is cytotoxic to prostate cancer cell lines as well as fresh prostate cancer cells at low micromolar concentrations, and importantly inhibits the termed tumor-initiating cells (TIC) subpopulations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Darinaparsin inhibits growth of the castrate-resistant Du145 prostate tumor propagated as xenograft in mice and inhibits the tumor-initiating potential of prostate cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

411.31

Formula

C12H22AsN3O6S

CAS No.
SMILES

O=C(NCC(O)=O)[[email protected]](CS[As](C)C)NC(CC[[email protected]](N)C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Darinaparsin
Cat. No.:
HY-14943
Quantity:
MCE Japan Authorized Agent: