2. Apoptosis
  3. Apoptosis
  4. Darinaparsin

Darinaparsin  (Synonyms: ZIO-101; S-Dimethylarsino-glutathione)

Cat. No.: HY-14943 Purity: ≥98.0%
COA Handling Instructions

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Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects.

For research use only. We do not sell to patients.

Darinaparsin Chemical Structure

Darinaparsin Chemical Structure

CAS No. : 69819-86-9

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5 mg USD 320 In-stock
10 mg USD 520 In-stock
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Based on 1 publication(s) in Google Scholar

Darinaparsin Related Antibodies

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Description

Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects[1].

In Vitro

Darinaparsin is cytotoxic to prostate cancer cell lines as well as fresh prostate cancer cells at low micromolar concentrations, and importantly inhibits the termed tumor-initiating cells (TIC) subpopulations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Darinaparsin Related Antibodies
In Vivo

Darinaparsin inhibits growth of the castrate-resistant Du145 prostate tumor propagated as xenograft in mice and inhibits the tumor-initiating potential of prostate cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

411.31

Formula

C12H22AsN3O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC(O)=O)[C@H](CS[As](C)C)NC(CC[C@H](N)C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (151.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4313 mL 12.1563 mL 24.3126 mL
5 mM 0.4863 mL 2.4313 mL 4.8625 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.4313 mL 12.1563 mL 24.3126 mL 60.7814 mL
5 mM 0.4863 mL 2.4313 mL 4.8625 mL 12.1563 mL
10 mM 0.2431 mL 1.2156 mL 2.4313 mL 6.0781 mL
15 mM 0.1621 mL 0.8104 mL 1.6208 mL 4.0521 mL
20 mM 0.1216 mL 0.6078 mL 1.2156 mL 3.0391 mL
25 mM 0.0973 mL 0.4863 mL 0.9725 mL 2.4313 mL
30 mM 0.0810 mL 0.4052 mL 0.8104 mL 2.0260 mL
40 mM 0.0608 mL 0.3039 mL 0.6078 mL 1.5195 mL
50 mM 0.0486 mL 0.2431 mL 0.4863 mL 1.2156 mL
60 mM 0.0405 mL 0.2026 mL 0.4052 mL 1.0130 mL
80 mM 0.0304 mL 0.1520 mL 0.3039 mL 0.7598 mL
100 mM 0.0243 mL 0.1216 mL 0.2431 mL 0.6078 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Darinaparsin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Darinaparsin69819-86-9ZIO-101 S-Dimethylarsino-glutathioneZIO101ZIO 101Apoptosisorganic arsenicalanticancer effectInhibitorinhibitorinhibit

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