1. PI3K/Akt/mTOR
    Stem Cell/Wnt
    Apoptosis
  2. GSK-3
    Apoptosis
  3. 9-ING-41

9-ING-41 

Cat. No.: HY-113914 Purity: 98.04%
Handling Instructions

9-ING-41 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK-3β. 9-ING-41 has anticancer activity.

For research use only. We do not sell to patients.

9-ING-41 Chemical Structure

9-ING-41 Chemical Structure

CAS No. : 1034895-42-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 138 In-stock
Estimated Time of Arrival: December 31
5 mg USD 155 In-stock
Estimated Time of Arrival: December 31
10 mg USD 265 In-stock
Estimated Time of Arrival: December 31
50 mg USD 960 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All GSK-3 Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

9-ING-41 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor[1]. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK-3β. 9-ING-41 has anticancer activity[2].

IC50 & Target[1]

GSK-3β

 

In Vitro

9-ING-41 (2, 4 μM; 48 hours) decreases neuroblastoma cell viability induces apoptosis[2].
9-ING-41 (1, 2 μM; 24 hours) is a potent cell cycle-blocking agent for lymphoma cells[2].
9-ING-41 (0.1-1 µM) inhibits GSK-3 leading to a decreased expression of the NF-κB target XIAP and significant apoptosis in neuroblastoma cells as shown by PARP cleavage, an apoptosis marker[1].
9-ING-41 (0.5, 1.0, 1.5, 2.0 μM) inhibits the proliferation rate of all TCL and MCL lines with concentrations as low as 1.0 mM[2].

Cell Viability Assay[2]

Cell Line: TCL and MCL lines
Concentration: 2, 4 μM
Incubation Time: 48 hours
Result: Induced apoptosis.

Cell Cycle Analysis[2]

Cell Line: Lymphoma cells (Jeko, Mino, and OCI-Ly cell lines)
Concentration: 1, 2 μM
Incubation Time: 24 hours
Result: Led to cell cycle arrest in G2/M.

Western Blot Analysis[1]

Cell Line: SK-N-DZ and SK-N-BE neuroblastoma cells
Concentration: 0.1, 1 µM
Incubation Time: 48 hours
Result: Inhibited GSK-3 leading to a decreased expression of the NF-κB target XIAP.
In Vivo

9-ING-41 (40 mg/kg/every other day; for 17 days) has single-agent antitumor activity in a mouse model of MCL[2].

Animal Model: NSG (NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ) mice[2]
Dosage: 40 mg/kg
Administration: Every other day; for 17 days
Result: Had single-agent antitumor activity in a mouse model of MCL.
Clinical Trial
Molecular Weight

404.35

Formula

C₂₂H₁₃FN₂O₅

CAS No.

1034895-42-5

SMILES

O=C(C(C1=COC2=CC=C(F)C=C12)=C3C4=CN(C)C5=C4C=C6C(OCO6)=C5)NC3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (618.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4731 mL 12.3655 mL 24.7310 mL
5 mM 0.4946 mL 2.4731 mL 4.9462 mL
10 mM 0.2473 mL 1.2366 mL 2.4731 mL
*Please refer to the solubility information to select the appropriate solvent.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

9-ING-41GSK-3ApoptosisGlycogen synthase kinase-3Glycogen synthase kinase 3GSK-3βapoptosiscellcyclearrestanticanceractivityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
9-ING-41
Cat. No.:
HY-113914
Quantity:
MCE Japan Authorized Agent: