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Adamalysin-like metalloproteinase with thrombospondin motifs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADAMTS (2) 11β-HSD (1) 5-HT Receptor (3) ADC Linker (4) Adenosine Receptor (1) Adenylate Cyclase (1) Akt (7) Aldehyde Dehydrogenase (ALDH) (2) Amino Acid Derivatives (6) Aminopeptidase (3) AMPK (2) Amyloid-β (3) Anaplastic lymphoma kinase (ALK) (2) Anion Exchangers (1) Antibiotic (8) Apolipoprotein (1) Apoptosis (43) Atg8/LC3 (2) Autophagy (4) Bacterial (29) Bcl-2 Family (3) Biochemical Assay Reagents (37) c-Fms (1) c-Myc (1) Cadherin (4) Calcium Channel (6) Carbonic Anhydrase (1) Caspase (8) Cathepsin (2) CCR (7) CD3 (1) CD47 (5) CDK (4) Cholinesterase (ChE) (1) Claudin (1) ClpP (2) Complement System (7) Connexin (2) CXCR (2) Dengue Virus (1) Deubiquitinase (2) DNA/RNA Synthesis (7) Dopamine Receptor (2) Drug Derivative (4) Drug Intermediate (6) Drug Isomer (2) Drug Metabolite (3) E1/E2/E3 Enzyme (3) EAAT (1) EBV (1) EGFR (3) Endogenous Metabolite (18) Endothelin Receptor (1) Environmental Pollutants (6) Ephrin Receptor (1) Epigenetic Reader Domain (5) ERK (5) Estrogen Receptor/ERR (2) Eukaryotic Initiation Factor (eIF) (3) Factor Xa (1) FAK (2) Farnesyl Transferase (1) Ferroptosis (4) FGFR (1) Fluorescent Dye (15) Formyl Peptide Receptor (FPR) (1) Fungal (10) FXR (1) GABA Receptor (1) Gap Junction Protein (3) Glycolate Oxidase (2) Glycosyltransferase (1) GSK-3 (1) HDAC (3) HIF/HIF Prolyl-Hydroxylase (2) Histone Acetyltransferase (1) Histone Demethylase (1) Histone Methyltransferase (5) HIV (7) HIV Protease (1) HSP (4) HSV (3) ICMT (1) IFNAR (2) iGluR (7) Influenza Virus (4) Insecticide (3) Integrin (7) Interleukin Related (13) IRE1 (1) Isotope-Labeled Compounds (10) JNK (2) Keap1-Nrf2 (4) Liposome (1) Lipoxygenase (1) mAChR (2) MAP3K (2) Mas-related G-protein-coupled Receptor (MRGPR) (1) MDM-2/p53 (1) Melanocortin Receptor (1) MHC (2) MicroRNA (2) Microtubule/Tubulin (2) Mineralocorticoid Receptor (1) Mitochondrial Metabolism (3) Mitophagy (2) MMP (132) MOFs (4) Molecular Glues (2) mRNA (43) mTOR (2) Mucin (1) nAChR (1) Necroptosis (2) Nectin-4 (1) NEKs (1) NF-κB (4) NO Synthase (6) NOD-like Receptor (NLR) (3) Nucleoside Antimetabolite/Analog (1) P2Y Receptor (2) p38 MAPK (5) p97 (1) Parasite (7) PARP (1) PCSK9 (1) PDK-1 (1) Peptide-Drug Conjugates (PDCs) (1) PGC-1α (1) Phosphodiesterase (PDE) (5) Phospholipase (1) PI3K (8) PKA (3) PKC (5) Potassium Channel (2) PPAR (1) Progesterone Receptor (1) Prostaglandin Receptor (3) PROTAC Linkers (1) PROTACs (1) Protease Activated Receptor (PAR) (1) Proteasome (4) Proton Pump (1) PSMA (2) Pyroptosis (1) RABV (1) Radionuclide-Drug Conjugates (RDCs) (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (10) Reference Standards (26) Reverse Transcriptase (2) RSV (1) SARS-CoV (8) SDCBP (1) Ser/Thr Kinase (1) Ser/Thr Protease (3) Small Interfering RNA (siRNA) (13) SOD (2) Sodium Channel (4) Somatostatin Receptor (2) Src (3) STAT (2) Stearoyl-CoA Desaturase (SCD) (1) STING (5) Survivin (1) Tau Protein (1) TGF-beta/Smad (3) TGF-β Receptor (10) Thrombin (2) Thrombopoietin Receptor (3) TMPRSS6 (1) TNF Receptor (6) Toll-like Receptor (TLR) (12) Transmembrane Glycoprotein (2) Transthyretin (TTR) (2) TRP Channel (2) Tyrosinase (3) VEGFR (4) Virus Protease (1) Wnt (1) YAP (2) α-synuclein (3) β-catenin (1)
By Research Areas:	Cancer (188) Cardiovascular Disease (40) Endocrinology (5) Infection (74) Inflammation/Immunology (163) Metabolic Disease (37) Neurological Disease (82)
Click Chemistry:	DBCO (2) Azide (2)
Oligonucleotides:	MicroRNAs (2) Flavoring Agents (1) Aptamers (9) Chemokine & Receptors (43) CpG ODNs (4) Cationic Lipids (1) mRNA (43) siRNA drugs (13) Cholesterol (1) siRNAs (13)

525

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

133

Peptides

Inhibitory Antibodies

Natural
Products

144

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: ADAMTS WNK Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70005B

Collagenase, Type II 10+ Cited Publications	MMP	Others
Collagenase, Type II is a microbially derived *matrix metalloproteinases* (MMPs) and zinc peptidase**. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .

HY-E70005D

Collagenase IV, Clostridium histolytica 10+ Cited Publications Collagenase, Type IV	MMP	Others
Collagenase, Type IV (EC 3.4.24.3) is a microbially derived *matrix metalloproteinases* (MMPs) and zinc peptidase**. Collagenase, Type IV degrades type IV collagen and type VII collagen, the main components of the basement membrane, and can also decompose basement matrix and elastin.

HY-E70005A

Collagenase, Type I 15+ Cited Publications EC 3.4.24.3	MMP	Others
Collagenase, Type I is a microbially derived *matrix metalloproteinases* (MMPs) and zinc peptidase**. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan .

HY-P0299

*LSKL, Inhibitor of Thrombospondin* (TSP-1)** 15+ Cited Publications	TGF-β Receptor	Cancer
LSKL, Inhibitor of Thrombospondin (TSP-1) is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) can readily crosse the blood-brain barrier .

HY-E70005C

Collagenase, Type III	MMP	Others
Collagenase, Type III is a microbially derived *matrix metalloproteinases* (MMPs) and zinc peptidase**. Collagenase, Type III breaksdown collagens1, 4, 9, 10, 14, fibronectin, MMP-9, gelatin, plasminogen, aggrecan,perlecan osteonectin

HY-115670

GW280264X 5+ Cited Publications	MMP	Inflammation/Immunology Cancer
GW280264X is the mixed **ADAM10/TACE (ADAM17) metalloproteinases** inhibitor. GW280264X potently blocks TACE (ADAM17) and *ADAM10* with IC₅₀s of 8.0 nM and 11.5 nM, respectively . ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells .

HY-12354

SB-3CT 25+ Cited Publications	MMP	Cancer
SB-3CT is a potent and competitive matrix metalloproteinase MMP-2 and MMP-9 inhibitor with K_i values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity .

HY-12795

Vps34-IN-1 10+ Cited Publications	PI3K Autophagy	Cancer
Vps34-IN-1 is a potent and selective inhibitor of class III Vps34 PI3K. Vps34-IN-1 inhibits phosphorylation of PtdIns by recombinant insect cell expressed Vps34-Vps15 complex with an IC₅₀ of ~25 nM. Vps34-IN-1 can suppress SGK3 activation by reducing PtdIns(3)P levels via lowering phosphorylation of T-loop and hydrophobic motifs. Vps34-IN-1 modulates autophagy .

HY-135232

MMP-9-IN-1 5+ Cited Publications	MMP	Cancer
MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs .

HY-E70005E

Collagenase, Type V 1 Publications Verification	MMP	Others
Collagenase, Type V is a microbially derived *matrix metalloproteinases* (MMPs) and zinc peptidase**. Collagenase, Type V breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .

HY-172162

LC-04-045	Molecular Glues NEKs Interleukin Related	Inflammation/Immunology Cancer
LC-04-045 is a selective NIMA-related kinase 7 (NEK7) molecular glue degrader. LC-04-045 induces NEK7 degradation via the CRBN-based ubiquitin-proteasome system, dependent on the glycine 57-containing degron motif. LC-04-045 inhibits secretion of downstream cytokines IL-1β and IL-18. LC-04-045 can be used for the research of lymphoblastic leukemia .

HY-103444

ARP-100 1 Publications Verification	MMP	Cancer
ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC₅₀=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM) .

HY-119711

NNGH	MMP	Cancer
NNGH is a stromelysin-1 (MMP-3) inhibitor. MMP-3 is both a direct transcriptional target and a necessary contributor of the Wnt/β-catenin signaling pathway. Matrix metalloproteinases (MMPs) play a well-defined role in later stages of tumor progression .

HY-P5322

**Thrombospondin (TSP-1)-derived CD36 binding motif**	Transmembrane Glycoprotein	Cardiovascular Disease Cancer
Thrombospondin (TSP-1)-derived CD36 binding motif is a bioactive hexapeptide. Thrombospondin (TSP-1)-derived CD36 binding motif interferes with the interaction between cells and the extracellular matrix by binding to CD36 and angiostatin, thereby affecting the cell adhesion and migration process. Thrombospondin (TSP-1)-derived CD36 binding motif inhibits platelet aggregation. Thrombospondin (TSP-1)-derived CD36 binding motif exerts an anti-tumor effect against colon cancer .

HY-P0301A

SLLK, Control Peptide for TSP1 InhibitorTFA	TGF-β Receptor	Cancer
SLLK, Control Peptide for TSP1 Inhibitor (TFA) is a control peptide for LSKL, which is a Thrombospondin (TSP-1) inhibitor.

HY-W004546

Abametapir	MOFs MMP Parasite	Infection
Abametapir is a metalloproteinase (MMP) inhibitor which is able to target metalloproteinases critical to egg hatching and louse development. Abametapir can inhibit hatching of both head and body louse .

HY-142069

KB-R7785	MMP	Neurological Disease Metabolic Disease
KB-R7785 is a matrix metalloproteinase (MMP) inhibitor, which improves insulin sensitivity by inhibiting TNF-α production. KB-R7785 can be used for diabetes research. KB-R7785 has a protective efficacy against focal cerebral ischemia .

HY-148100

Emapticap pegol 1 Publications Verification NOX-E36	CCR	Inflammation/Immunology Cancer
Emapticap pegol (NOX-E36) is a inhibitor of pro-inflammatory *chemokine C-C motif-ligand 2* (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36). mNOX-E36 is a murine-specific analogue of NOX-E36, an anti-MCP-1 L-RNA aptamer that was previously shown to attenuate liver fibrosis in mice .

HY-107823

Cholesteryl acetate Cholesterol 3-acetate; Cholesterin acetate; Cholesterol 3β-acetate	Endogenous Metabolite	Others
Cholesteryl acetate (Cholesterol 3-acetate) is a cholesterol ester that is exported from Saccharomyces cerevisiae via a Pry1-dependent mechanism. Cholesteryl acetate binds to the CAP superfamily protein Pry1 via interactions dependent on Pry1’s caveolin-binding motif .

HY-115719

NR162	Ser/Thr Kinase	Neurological Disease
NR162 is a selective CASK (Ca ²⁺/calmodulin-dependent Ser/Thr kinase) inhibitor with an IC₅₀ of 80 nM and a Kd of 22 nM. NR162 shows about 50-fold selectivity for CASK than TYRO3. NR162 targets the unique GFG motif of CASK and has excellent shape complementarity to the CASK ATP binding pocket. NR162 can be used for the research of neurological diseases .

HY-100518

T-26c 3 Publications Verification	MMP	Inflammation/Immunology
T-26c, a chemical probe, is highly potent and selective *matrix metalloproteinase-13 (MMP-13)* inhibitor with an IC₅₀ of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes .

HY-P0144

Thrombospondin-1 (1016-1023) (human, bovine, mouse)	CD47 Apoptosis	Inflammation/Immunology
Thrombospondin-1 (1016-1023) (human, bovine, mouse), is the C-terminal end of the native sequence of Thrombospondin-1 (TSP-1), is a CD47 agonist peptide .

HY-P0299A

*LSKL, Inhibitor of Thrombospondin* (TSP-1) TFA** 15+ Cited Publications	TGF-β Receptor	Cancer
LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) TFA can readily crosse the blood-brain barrier .

HY-109097

Otaplimastat SP-8203	MMP iGluR	Neurological Disease Inflammation/Immunology Cancer
Otaplimastat (SP-8203), a *matrix metalloproteinase* (MMP) inhibitor, blocks N-methyl-D-aspartate (NMDA) receptor**-mediated excitotoxicity in a competitive manner. Otaplimastat also exhibits anti-oxidant activity. Otaplimastat can be used for the research of brain ischemic injury .

HY-W127716

Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 1 Publications Verification	Fluorescent Dye	Cancer
Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 is a potent ruthenium-based dye. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can bu used as an effective quencher of quantum dots (QDs) fluorescence and the capture probe of virus antigen EV71. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can be used sensitive electrogenerated chemiluminescence (ECL) labels for detection of matrix metalloproteinases (MMPs) .

HY-13545

ABT-510 1 Publications Verification	Apoptosis	Inflammation/Immunology Cancer
ABT-510 is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD) .

HY-131349

CCR4-351	CCR	Cancer
CCR4-351 is an orally active, potent and selective CCR4 antagonist. CCR4-351, featuring a novel piperidinyl-azetidine motif, has IC₅₀s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 has antitumor activity .

HY-P1075

CALP3 2 Publications Verification	Calcium Channel	Neurological Disease Cancer
CALP3, a Ca ²⁺-like peptide, is a potent Ca ²⁺ channel blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .

HY-13545B

ABT-510 acetate 1 Publications Verification	Apoptosis	Inflammation/Immunology Cancer
ABT-510 acetate is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 acetate also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 acetate can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD) .

HY-107637

ONO-4817	MMP	Cardiovascular Disease
ONO-4817 is a potent inhibitor of matrix metalloproteinase (MMP). Inhibition of matrix metalloproteinases (MMPs) is expected to suppress atherosclerotic neointimal proliferation and thus limits atheromatous plaque progression. ONO-4817 suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit .

HY-151746

N3-Gly-Gly-Gly-OH	ADC Linker	Others
N3-Gly-Gly-Gly-OH is a oligo-Gly click chemistry reagent containing an azide group. Oligo-Gly also has been used as linker to combine different subunits of dimeric or oligomeric proteins or to create artificial multi-domain proteins. By modification into Gly-Gly-Gly-Ser motifs high solubility can be achieved . N3-Gly-Gly-Gly-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-101703

Ro 31-9790 1 Publications Verification GI4747	MMP	Inflammation/Immunology
Ro 31-9790 is a synthetic metalloproteinase (MMP) inhibitor.

HY-101535

ARP101 1 Publications Verification	Atg8/LC3 MMP	Cancer
ARP101 is a potent and selective inhibitor matrix metalloproteinase-2 (MMP-2). ARP101 induces autophagy-associated cell death in cancer cells. ARP101 is effective in inducing the formation of autophagosome and conversion of LC3I into LC3II .

HY-W101299

*N-Acetyl-D-allo-isoleucine*	Amino Acid Derivatives	Metabolic Disease
N-Acetyl-D-allo-isoleucine is an amino acid derivative. N-Acetyl-D-allo-isoleucine is promising for research of amino acid metabolism, such as abnormal isoleucine metabolism .

HY-P11032

Mp-4D7-pF2	SARS-CoV Virus Protease	Infection
Mp-4D7-pF2, a cell-penetrating bicyclic peptide, is a noncovalent SARS-CoV-2 main protease inhibitor with an IC₅₀ of 4.51 μM. Mp-4D7-pF2 has an antiviral activity against SARS-CoV-2 with no cytotoxicity. Mp-4D7-pF2 can used for COVID-19 infections research .

HY-P5419A

WAAG-3R TFA	Biochemical Assay Reagents	Others
WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)

HY-P10043

MMP-1 Substrate	MMP	Others
MMP-1 Substrate is a matrix metalloproteinase-1 (MMP-1) selective substrate that can be used for the fluorometric determination of MMP-1 enzymatic activity .

HY-N16409

Berkeleyamide C	MMP Caspase	Inflammation/Immunology Cancer
Berkeleyamide C is a selective matrix metalloproteinase-3 (MMP-3) and caspase-1 inhibitor. Berkeleyamide C blocks MMP-3-mediated tumor cell invasion and metastasis, as well as the abnormal activation of inflammation and apoptosis related to caspase-1. Berkeleyamide C is promising for research of cancers and inflammation-related diseases .

HY-P3968

Thrombospondin-1 (1016-1021) (human, bovine, mouse)	CD47	Others
Thrombospondin-1 (1016-1021) (human, bovine, mouse), a Thrombospondin-1-derived peptide, is a truncated peptide devoid of CD47-binding activity .

HY-P4002

Adamtsostatin 18	ADAMTS	Cancer
Adamtsostatin 18 is an anti-angiogenic peptide derived from proteins containing type I thrombospondin motifs. Adamtsostatin 18 inhibits cell migration and proliferation .

HY-135859A

NH2-MPAA-NODA TFA	ADC Linker	Cancer
NH2-MPAA-NODA TFA is a nitroveratryl-based photocleavable linker, it has a NODA motif and a methyl phenyl acetic acid (MPAA) backbone . NH2-MPAA-NODA can be used as a radiolabel by labeling with ¹⁸F-fluoride.

HY-131349A

CCR4-351 hydrochloride	CCR	Metabolic Disease Cancer
CCR4-351 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4-351 hydrochloride, featuring a novel piperidinyl-azetidine motif, has IC₅₀s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 hydrochloride has antitumor activity .

HY-P3477

Mca-PLA-Nva-Dap(Dnp)-AR-NH2	Fluorescent Dye	Others
Mca-PLA-Nva-Dap(Dnp)-AR-NH2 is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) .

HY-P11205A

Cys-PKHB1 TFA Cys-txCD47 TFA	CD47 Reactive Oxygen Species (ROS) Thrombopoietin Receptor	Inflammation/Immunology Cancer
Cys-PKHB1 (Cys-txCD47) TFA is a peptide conjugated to PKHB1, a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. PKHB1 induces mitochondrial alterations, ROS generation, intracellular Ca ⁺ accumulation, and calcium-dependent cell death in breast cancer cells. PKHB1 induces immune system activation in breast cancer cells through immunogenic cell death .

HY-178489

BGC1614	Nectin-4	Cancer
BGC1614 is a Nectin-4-targeting bicyclic toxin conjugate (BTC) belonging to the category of peptide-drug conjugates (PDCs). BGC1614 exhibits strong targeted binding ability to Nectin-4, with an K_D of 3.859 × 10 ^-7 M. BGC1614 exhibits superior antitumor efficacy in nude mice bearing PC-3 and N87 tumor xenografts. BGC1614 can be used for research related to Nectin-4-overexpressing tumors (such as prostate cancer, gastric cancer) .

HY-P4003

Adamtsostatin 16	ADAMTS	Cardiovascular Disease
Adamtsostatin 16 is an anti-angiogenic 17-amino acid peptide containing type I thrombospondin motifs .

HY-131417

cis-ACCP	MMP	Infection Cardiovascular Disease Inflammation/Immunology Cancer
cis-ACCP is an orally active antimetastatic *matrix metalloproteinase-2 (MMP-2)* selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC₅₀ values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases .

HY-P2641

Peptide 74	MMP	Cancer
Peptide 74 is a synthetic peptide containing the prodomain sequence of matrix metalloproteinase (MMP). Peptide 74 inhibits the activated form of the 72-kDa type IV collagenase in vitro .

HY-107640

WAY-170523	MMP	Cancer
WAY-170523 is a potent and selective MMP-13 (matrix metalloproteinase-13) inhibitor, with an IC₅₀ of 17 nM. WAY-170523 can directly attenuate ERK1/2 phosphorylation. WAY-170523 inhibits the invasion of PC-3 cells, can be used for prostate cancer research .

HY-175558

MMP-9-IN-12	MMP Apoptosis Reactive Oxygen Species (ROS)	Cancer
MMP-9-IN-12 is a matrix metalloproteinase-9 (MMP-9) inhibitor with an IC₅₀ of 6.57 μM. MMP-9-IN-12 shows an IC₅₀ value of 1.54 μM for HCT-116 cells. MMP-9-IN-12 induces cell apoptosis, ROS production and mitochondrial depolarization. MMP-9-IN-12 inhibits cells migration and disrupts cell cycle progression. MMP-9-IN-12 can be used for the research of colorectal cancer (CRC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0018

Daidzin Maximum Cited Publications 12 Publications Verification Daidzoside; NPI-031D; Daidzein 7-O-glucoside	Monophenols Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Other Diseases Phenols Plants Disease Research Fields Isoflavones Source Classification	Mitochondrial Metabolism Reverse Transcriptase Aldehyde Dehydrogenase (ALDH)
Daidzin is an isoflavone with antioxidant, anticancer, and antiatherosclerotic activities. Daidzin is a potent and selective inhibitor of mitochondrial ALDH-2. Daidzin reduces ethanol consumption .

HY-N1420

Rhamnose 1 Publications Verification L-Rhamnose	Structural Classification Classification of Application Fields Plants Endogenous metabolite Sweeteners Monosaccharides Food Research Microorganisms other families Disease Research Fields Saccharides Source Classification Cancer	Environmental Pollutants Endogenous Metabolite PKA MMP Interleukin Related
Rhamnose (L-Rhamnose ) is an orally active deoxysugar. Rhamnose can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas .

HY-N2360

Hinokiflavone 5+ Cited Publications	Flavonoids Classification of Application Fields Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Source Classification Cancer	E1/E2/E3 Enzyme Apoptosis MMP ClpP
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC₅₀ value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

HY-N0337

*Eugenol,98% (stabilized with* TBC)** Maximum Cited Publications 8 Publications Verification	Infection Structural Classification Monophenols Classification of Application Fields Phenols Piperaceae Plants Inflammation/Immunology Disease Research Fields Piper nigrum Linn. Source Classification	Environmental Pollutants Parasite Reactive Oxygen Species (ROS) Bacterial Apoptosis Ferroptosis
Eugenol is an essential oil found in cloves with antibacterial, anthelmintic and antioxidant activity. Eugenol is shown to inhibit lipid peroxidation.

HY-N1463

Luteolin 7-O-glucuronide 3 Publications Verification Luteolin 7-glucuronide	Structural Classification Flavonoids other families Classification of Application Fields Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	MMP
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .

HY-N0368

*Linalool,98% (stabilized with* MEHQ)** 4 Publications Verification	Cardiovascular Disease Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Amberboa moschata (L.) DC. Umbelliferae Plants Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Apoptosis iGluR Endogenous Metabolite Bacterial TNF Receptor
Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-N1454

Apigenin-7-glucuronide 4 Publications Verification Apigenin 7-O-glucuronide	Structural Classification Flavonoids other families Classification of Application Fields Flavones Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	MMP
Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC₅₀s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-W008642

Leu-Leu-OH L-Leucyl-L-leucine; Leu-Leu; H-Leu-Leu-OH	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Amino Acid Derivatives
Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

HY-N0803

*Myrcene,75% (stabilized with* BHT)** β-Myrcene	Structural Classification Other Monoterpenes Microorganisms Pinus sylvestris Linn. var. mongolica Litv. Classification of Application Fields Pinaceae Terpenoids Other Diseases Plants Disease Research Fields Source Classification	Environmental Pollutants NF-κB
Myrcene (β-Myrcene) is a type of aromatic compound that inhibits TNFα and NF-κB activity. Myrcene has anti-invasive action, inhibits cell cycle, and leads to cancer cell apoptosis. Myrcene has strong blood protection effect, anti-inflammation, and anti-inflammatory activity .

HY-122815

Fusicoccin Fusicoccin A	Microorganisms Classification of Application Fields Terpenoids Diterpenoids Disease Research Fields Source Classification Cancer	Apoptosis
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H ⁺-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .

HY-N0712

Typhaneoside 3 Publications Verification	Cardiovascular Disease Flavonols Structural Classification Flavonoids Typhaceae Classification of Application Fields Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields Source Classification	mTOR Akt FXR PI3K Autophagy Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Calcium Channel
Typhaneoside is an orally active activator of PI3K/Akt/mTOR and farnesoid X receptor. Typhaneoside promotes the activation of AMPK and Caspase-3, induces apoptosis, ferroptosis, autophagy, ROS accumulation, cell cycle arrest at the G₂/M phase, and reduces cancer cell viability. Typhaneoside improves glucose and lipid metabolism, alleviates inflammatory responses, oxidative stress and hepatic lipid accumulation, and exerts hepatoprotective effects. Typhaneoside can be used in research related to heart failure after myocardial infarction, acute myeloid leukemia, non-alcoholic fatty liver disease and neurological disorders .

HY-N1420A

Rhamnose monohydrate 1 Publications Verification L-Rhamnose monohydrate	Microorganisms other families Classification of Application Fields Plants Disease Research Fields Saccharides Monosaccharides Source Classification Cancer	Endogenous Metabolite MMP Interleukin Related PKA
Rhamnose monohydrate (L-Rhamnose monohydrate) is an orally active deoxysugar. Rhamnose monohydrate can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose monohydrate can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose monohydrate shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas .

HY-B0914

*10-Undecenoic acid,98% (stabilized with* TBC)** 2 Publications Verification Undecylenic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Bacterial Fungal Proteasome Amyloid-β Reactive Oxygen Species (ROS)
10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-N6013

Aloin (mixture of A&B)	Infection Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Inflammation/Immunology Disease Research Fields Source Classification	MMP Proteasome Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Bacterial Fungal
Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix *metalloproteinases* and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .

HY-N5072

Desmethylglycitein 3 Publications Verification 4',6,7-Trihydroxyisoflavone	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Phenols Polyphenols Plants Disease Research Fields Isoflavones Source Classification Cancer	CDK PI3K PKC
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity . Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

HY-N4183

Licoflavone C 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification Cancer	Apoptosis Caspase Estrogen Receptor/ERR
Licoflavone C is a broad-spectrum antiviral inhibitor with estrogen-like properties. Licoflavone C binds to viral endonuclease (CEN) and inhibits the replication of various bunyaviruses including severe fever with thrombocytopenia syndrome virus (SFTSV) and lymphocytic choriomeningitis virus in a non-substrate competitive manner. The IC₅₀ values of Licoflavone C against SFTSV CEN and SFTSV CEN are 35.5 μM and 135.8 μM, respectively, and its K_d value against SFTSV CEN is 9.53 μM. After viral entry into cells, Licoflavone C reduces viral loads in mouse tissues in a dose-dependent manner, and exhibits extremely low cytotoxicity and genotoxicity. Licoflavone C induces apoptosis by increasing caspase 3/7 activity, blocks the cell cycle, and alleviates chemotherapy-induced chromosomal damage. Licoflavone C is applicable to the research on severe fever with thrombocytopenia syndrome and related viral infection mechanisms .

HY-N0660

Jujuboside B	Cardiovascular Disease Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification	Apoptosis PARP Caspase AMPK Autophagy VEGFR Keap1-Nrf2 STING 11β-HSD Ferroptosis PI3K Akt p38 MAPK ERK
Jujuboside B is a bioactive saponin component isolated from Ziziphi Spinosae Semen (sour jujube seed), with oral efficacy and blood-brain barrier permeability. Jujuboside B induces acute leukemia cell death and drives necroptosis apoptosis by activating the RIPK1/RIPK3/MLKL pathway. Jujuboside B upregulates the expression of NOXA, PARP and caspase-3, activates AMPK, inhibits the proliferation of breast cancer cells, and induces cell apoptosis and autophagy. Jujuboside B inhibits angiogenesis and tumor growth by blocking the VEGFR-2 signaling pathway. Jujuboside B alleviates liver injury in mice by regulating the Nrf2-STING signaling pathway . Jujuboside B alleviates liver injury by regulating anti-inflammatory responses and downregulating the expression of 11β-HSD2. Jujuboside B induces ferroptosis and overcomes radioresistance in non-small cell lung cancer via the PPARγ-ATF3-Gpx4 signaling pathway. Jujuboside B exerts inhibitory effects on platelet aggregation. Jujuboside B inhibits febrile seizures by suppressing the activity of AMPA receptors. Jujuboside B reverses chronic unpredictable mild stress-promoted tumor progression by blocking the PI3K/Akt and MAPK/ERK pathways and dephosphorylating CREB signaling. Jujuboside B is applicable to related studies on acute leukemia, breast cancer, PM_2.5-induced lung injury, hepatotoxicity, liver injury, colorectal cancer, non-small cell lung cancer, thromboembolic diseases, cardiovascular diseases associated with high platelet aggregation, febrile seizures, and depressive-like phenotypes .

HY-107823

Cholesteryl acetate Cholesterol 3-acetate; Cholesterin acetate; Cholesterol 3β-acetate	Structural Classification Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Cholesteryl acetate (Cholesterol 3-acetate) is a cholesterol ester that is exported from Saccharomyces cerevisiae via a Pry1-dependent mechanism. Cholesteryl acetate binds to the CAP superfamily protein Pry1 via interactions dependent on Pry1’s caveolin-binding motif .

HY-N10633

LSTc LS-tetrasaccharide c	Infection Polysaccharides Classification of Application Fields Endogenous metabolite Disease Research Fields Saccharides Source Classification Cancer	Others
LSTc (LS-tetrasaccharide c) is a human lactooligosaccharide presents on glycoproteins and glycolipids. LSTc is also a specific human JC polyomavirus (JCV) recognition motif. LSTc has good potential for the study of progressive multifocal leukoencephalopathy (PML) .

HY-N1401

20(R)-Ginsenoside Rh2 2 Publications Verification	Panax ginseng C. A. Meyer Infection Triterpenes Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	MMP Apoptosis HSV DNA/RNA Synthesis NO Synthase Prostaglandin Receptor Reactive Oxygen Species (ROS) Akt
20(R)-Ginsenoside Rh2 is an orally active protopanaxadiol-type saponin with multiple biological activities. 20(R)-Ginsenoside Rh2 exerts a significant inhibitory effect on non-small cell lung cancer and liver cancer by inducing cell cycle arrest and promoting apoptosis. 20(R)-Ginsenoside Rh2 exerts anti-γ-herpesvirus effects by inhibiting viral DNA replication. 20(R)-Ginsenoside Rh2 inhibits inflammatory mediators by reducing the levels of NO, PGE2, and ROS; it can delay skin photoaging by reducing ROS and inhibiting MMP-9/2 activity. 20(R)-Ginsenoside Rh2 accelerates the recovery after muscle injury by activating the Akt1/PKB signaling pathway. 20(R)-Ginsenoside Rh2 can inhibit osteoclast formation and exert an anti-osteoporosis effect .

HY-N0698

Crocin II	Structural Classification Neurological Disease Classification of Application Fields Terpenoids Rubiaceae Diterpenoids Plants Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite α-synuclein
Crocin II is an inhibitor targeting α-synuclein aggregation, with a IC₅₀ of 0.541 μM and a EC₅₀ of 3.63 μM. Crocin II inhibits α-synuclein aggregation and dissociates pre-formed α-synuclein fibrils. Crocin II possesses antioxidant, anticancer and antidepressant activities. Crocin II is applicable to research related to neurological disorders such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy, as well as cancers .

HY-Y0442

2-Methylbenzaldehyde	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Insecticide
2-Methylbenzaldehyde is an acaricide found in Morinda officinalis. 2-Methylbenzaldehyde exerts fumigant and contact acaricidal activity against Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Haemaphysalis longicornis. 2-Methylbenzaldehyde can be used for the research of severe fever with thrombocytopenia syndrome .

HY-N7627

Regaloside C	Cardiovascular Disease Structural Classification Classification of Application Fields Simple Phenylpropanols Gramineae Secale cereale Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification	Estrogen Receptor/ERR Toll-like Receptor (TLR) Akt MMP HSP
Regaloside C is an anti-inflammatory agent and antioxidant that scavenges ABTS and DPPH free radicals. Regaloside C targets multiple molecules including TNF-α, MMP-2, ERα, AKT1, TLR4 and HSP90-α. Regaloside C is applicable to research related to inflammatory diseases .

HY-N2503

Ginsenoside F4	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	Apoptosis MMP
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis . Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .

HY-W041193

3-Hydroxy-2-pyrone	Structural Classification Natural Products Actinidia chinensis Planch. Plants Actinidiaceae Source Classification	MMP Lipoxygenase Tyrosinase
3-Hydroxy-2-pyrone (Compound 12d) is a metalloenzyme inhibitor. 3-Hydroxy-2-pyrone shows an inhibition rate of approximately 50% for matrix metalloproteinases (MMP) and the inhibition rate for non-heme iron enzyme 5-lipoxygenase (5-LOX) was over 70% at 1 mM. 3-Hydroxy-2-pyrone also has certain inhibitory activity against copper-dependent enzyme tyrosinase. 3-Hydroxy-2-pyrone can be used for the research of cancer, infection and inflammation .

HY-N0018R

Daidzin (Standard) Daidzoside (Standard); NPI-031D (Standard); Daidzein 7-O-glucoside (Standard)	Structural Classification Monophenols Flavonoids Leguminosae Glycine max (L.) merr Phenols Plants Isoflavones Source Classification	Reference Standards Mitochondrial Metabolism Reverse Transcriptase Aldehyde Dehydrogenase (ALDH)
Daidzin (Standard) is the analytical standard of Daidzin. This product is intended for research and analytical applications. Daidzin is an isoflavone with antioxidant, anticancer, and antiatherosclerotic activities. Daidzin is a potent and selective inhibitor of mitochondrial ALDH-2. Daidzin reduces ethanol consumption .

HY-N1420AR

Rhamnose monohydrate (Standard) L-Rhamnose monohydrate (Standard)	Structural Classification Microorganisms other families Plants Saccharides Monosaccharides Source Classification	Reference Standards Endogenous Metabolite MMP Interleukin Related PKA
Rhamnose monohydrate (Standard) is the analytical standard of Rhamnose monohydrate (HY-N1420A). Rhamnose monohydrate (L-Rhamnose monohydrate) is an orally active deoxysugar. Rhamnose monohydrate can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose monohydrate can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose monohydrate shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas .

HY-N16409

Berkeleyamide C	Natural Products Microorganisms Source Classification	MMP Caspase
Berkeleyamide C is a selective matrix metalloproteinase-3 (MMP-3) and caspase-1 inhibitor. Berkeleyamide C blocks MMP-3-mediated tumor cell invasion and metastasis, as well as the abnormal activation of inflammation and apoptosis related to caspase-1. Berkeleyamide C is promising for research of cancers and inflammation-related diseases .

HY-N2205

Esculentoside H 2 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Phytolacca acinosa Roxb. Plants Disease Research Fields Phytolaccaceae Source Classification Cancer	NF-κB JNK
Esculentoside H (EsH) is a saponin isolated from the root extract of perennial plant Phytolacca esculenta . Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease . Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and NF-κB signaling-mediated matrix metalloproteinases-9 (MMP-9) expression .

HY-N1454R

Apigenin-7-glucuronide (Standard) Apigenin 7-O-glucuronide (Standard)	Structural Classification Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	Reference Standards MMP
Apigenin-7-glucuronide (Standard) is the analytical standard of Apigenin-7-glucuronide. This product is intended for research and analytical applications. Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-W588249

Sabinene hydrate	Structural Classification Other Monoterpenes Juniperus communis L. Cupressaceae Terpenoids Plants Source Classification	Bacterial Endogenous Metabolite
Sabinene hydrate is a volatile organic compound of a bicyclic monoterpene alcohol. Sabinene hydrate, as a plant secondary metabolite, is naturally present in various plants and their essential oils. Sabinene hydrate exhibits broad-spectrum but varying-intensity antibacterial activity, with the greatest sensitivity to Gram-positive bacteria, especially Bacillus subtilis (MIC = 0.0312 mg/mL) and Staphylococcus aureus (MIC = 0.0625 mg/mL). Sabinene hydrate also shows certain sensitivity to Escherichia coli and Candida albicans, with MIC values of 0.125 mg/mL for both. Sabinene hydrate can be used in the research of the ecological functions of plant defense substances .

HY-N16408

Berkeleyamide B	Natural Products Microorganisms Source Classification	MMP Caspase
Berkeleyamide B is a dual matrix metalloproteinase-3 (MMP-3) and caspase-1 inhibitor. Berkeleyamide B is promising for research of cancers and inflammatory disease (e.g., rheumatoid arthritis) .

HY-N6739R

Beauvericin (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Macrolide Antibiotics Antibiotics Antibacterial Disease Research Endogenous metabolite Source Classification	Reference Standards Bacterial Apoptosis Fungal PI3K Akt TNF Receptor Interleukin Related
Doxycycline (monohydrate) (Standard) is the analytical standard of Doxycycline (monohydrate). This product is intended for research and analytical applications. Doxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor .

HY-N2625

Harmalol	Alkaloids Nitrariaceae Peganum harmala L. Other Alkaloids Plants Source Classification	Apoptosis
Harmalol is a β-carbazine alkaloid with anticancer activity. Harmalol binds and interacts with several natural and synthetic nucleic acids of different motifs, including DNA and RNA. In addition, harmalol has an apoptosis-inducing effect on human hepatoma cells in vitro .

HY-N1463R

Luteolin 7-O-glucuronide (Standard) Luteolin 7-glucuronide (Standard)	Structural Classification Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	Reference Standards MMP
Luteolin 7-O-glucuronide (Standard) is the analytical standard of Luteolin 7-O-glucuronide. This product is intended for research and analytical applications. Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .

HY-N2360R

Hinokiflavone (Standard)	Structural Classification Flavonoids Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Source Classification	Reference Standards E1/E2/E3 Enzyme Apoptosis MMP ClpP
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

HY-N4075R

O-Desmethylangolensin (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Phenols Polyphenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
20(R)-Ginsenoside Rh2 (Standard) is the analytical standard of 20(R)-Ginsenoside Rh2. This product is intended for research and analytical applications. 20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity . 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC50 of 2.77 μM for murine MHV-68 .

HY-N5072R

Desmethylglycitein (Standard) 4',6,7-Trihydroxyisoflavone (Standard)	Structural Classification Flavonoids Leguminosae Glycine max (L.) merr Phenols Polyphenols Plants Isoflavones Source Classification	Reference Standards CDK PI3K PKC
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity . Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

HY-N6013R

Aloin (mixture of A&B) (Standard)	Structural Classification Liliaceae Ketones, Aldehydes, Acids Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Source Classification	Reference Standards Proteasome MMP Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Fungal Bacterial
Aloin (mixture of A&B) (Standard) is the analytical standard of Aloin (mixture of A&B) (HY-N6013). This product is intended for research and analytical applications. Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix *metalloproteinases* and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .

HY-N5185

Cyclothiazomycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal
Cyclothiazomycin selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. Cyclothiazomycin has weak antifungal activity .

HY-N8501

Emestrin	Structural Classification Natural Products Microorganisms Source Classification	Bacterial
Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities. It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC₅₀s=3.94, 0.6, 2.21, 4.55, and 2.21 μg/mL, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC₅₀=5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestrin (0.1 μg/mL) induces apoptosis in HL-60 cells. It induces heart, thymus, and liver tissue necrosis in mice when administered at doses ranging from 18 to 30 mg/kg.

HY-N11434

Anisocoumarin H	Adenocarpus cincinnatus (Ball) Maire Coumarins Phenylpropanoids Plants Compositae Source Classification	Fungal
Anisocoumarin H is a coumarin that exhibits antifungal activity. Anisocoumarin H shows the activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs of 62.5 µg/mL .

HY-N14770

Matlystatin E	Natural Products Microorganisms Source Classification	MMP
Matlystatin E is a metalloproteinase (MMP) inhibitor .

HY-N14771

Matlystatin F	Natural Products Microorganisms Source Classification	MMP
Matlystatin F is a metalloproteinase (MMP) inhibitor .

HY-N14761

Matlystatin D	Natural Products Microorganisms Source Classification	MMP
Matlystatin D is a metalloproteinase (MMP) inhibitor .

HY-N13141

Tetracenomycin X	Structural Classification Natural Products Microorganisms Source Classification	Others
Tetracenomycin X is a natural aromatic polyketide compound. Tetracenomycin X can inhibit peptide bond formation between an incoming aminoacyl-tRNA and a terminal Gln-Lys (QK) motif in the nascent polypeptide. Tetracenomycin X can be used for the development of novel aromatic polyketide antibiotics .

HY-W008642R

Leu-Leu-OH (Standard) L-Leucyl-L-leucine (Standard); Leu-Leu (Standard); H-Leu-Leu-OH (Standard)	Natural Products Endogenous metabolite Source Classification	Amino Acid Derivatives Reference Standards
Leu-Leu-OH (Standard) is the analytical standard of Leu-Leu-OH (HY-W008642). This product is intended for research and analytical applications. Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

HY-N17556

(+)-Mornaphthoate B	Structural Classification Monophenols Rubiaceae Phenols Plants Morinda officinalis How Source Classification	Drug Derivative
(+)-Mornaphthoate B is a Methyl 2-naphthoate derivative. (+)-Mornaphthoate B can be isolated from the roots of Morinda officinalis var. officinalis. (+)-Mornaphthoate B exhibits no activity against Acetylcholinesterase and Butyrylcholinesterase. (+)-Mornaphthoate B can be used in the research of non-small cell lung cancer and triple-negative breast cancer .

HY-N17727

Divaricatol	Structural Classification Monophenols Xeranthemum annuum L. Phenols Umbelliferae Plants Source Classification	Interleukin Related TNF Receptor
Divaricatol is an orally ative chromone natural product and an active component in Saposhnikovia divaricata. Divaricatol reduces the release of pro-inflammatory cytokines and restores immune homeostasis by stably binding to 5KIR (a target of the TNF/IL-17 pathway). Divaricatol exerts analgesic effects in mouse models. Divaricatol can be used in the research of pain, diarrhea-predominant irritable bowel syndrome (IBS-D) and qi deficiency syndrome .

Cat. No.	Product Name	Chemical Structure

HY-W010243S

Methylisothiazolinone-d3 hydrochloride

Methylisothiazolinone-d₃ hydrochloride is the deuterium labeled Methylisothiazolinone hydrochloride (HY-W010243). Methylisothiazolinone hydrochloride is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone hydrochloride can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone hydrochloride can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone hydrochloride can cause mitochondrial damage in the endothelium of rat cerebral blood vessels .

HY-W017163S

*7-Methylxanthine-2,4,5,6-13C4, 1,3-15N2 (with* variable 15N labeling at N9)**
7-Methylxanthine-2,4,5,6- ¹³C₄, 1,3- ¹⁵N₂ (with variable ¹⁵N labeling at N₉) is the ¹³C and ¹⁵N labeled 7-Methylxanthine . 7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi .

HY-P3448S

Certepetide-13C6,15N2

Certepetide- ¹³C₆, ¹⁵N₂ (CEND-1- ¹³C₆, ¹⁵N₂) is the ¹³C- and ¹⁵N-labeled Certepetide (HY-P3448). Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors .

HY-77813S

Benzyl isothiocyanate-d7
Benzyl isothiocyanate-d₇ is the deuterium labeled Benzyl isothiocyanate. Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity . Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells .

HY-W771025

1,4-Diiodobutane-13C4
1,4-Diiodobutane- ¹³C₄ (Tetramethylene Iodide (stabilized with Copper chip)- ¹³C₄) is the ¹³C-labeled 1,4-Diiodobutane (HY-W004871).

HY-W110726S1

1-Octen-3-one-d3
1-Octen-3-one-d₃ is deuterated labeled 1-Octen-3-one.

HY-W110726S

1-Octen-3-one-d5
1-Octen-3-one-d₅ is deuterated labeled 1-Octen-3-one.

HY-P3448S1

Certepetide-13C2,15N

Certepetide- ¹³C₂, ¹⁵N (CEND-1- ¹³C₂, ¹⁵N) is the ¹³C- and ¹⁵N-labeled Certepetide (HY-P3448). Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors .

HY-P3252AS

Pegcetacoplan-13C3,15N TFA

Pegcetacoplan- ¹³C₃, ¹⁵N TFA is the ¹³C- and ¹⁵N-labeled Pegcetacoplan TFA. Pegcetacoplan is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD).

HY-W143131S

*Diethyl itaconate,98% (stabilized with* TBC)-13C5**
Diethyl itaconate,98% (stabilized with TBC)- ¹³C₅ (Itaconic Acid Diethyl Ester (stabilized with TBC)- ¹³C₅) is the ¹³C-labeled Diethyl itaconate,98% (stabilized with TBC) (HY-W143131).

HY-W701041

2,5,8,11-Tetraoxadodecane-d6
2,5,8,11-Tetraoxadodecane-d₆ (Triglyme (stabilized with BHT)-d₆) is the deuterium labeled 2,5,8,11-Tetraoxadodecane (HY-W016612).

Targets Recommended: ADAMTS WNK Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110397G

KP-457	MMP	Cardiovascular Disease
KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

HY-N0565AG

Doxycycline (hydrochloride)	Apoptosis MMP Akt PI3K	Infection Neurological Disease Inflammation/Immunology Cancer
Doxycycline hydrochloride GMP is Doxycycline (hydrochloride) (HY-N0565A) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Doxycycline hydrochloride is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hydrochloride is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hydrochloride also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hydrochloride induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hydrochloride also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hydrochloride has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

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