MMP-9-IN-12
MMP-9-IN-12 is a matrix metalloproteinase-9 (MMP-9) inhibitor with an IC50 of 6.57 μM. MMP-9-IN-12 shows an IC50 value of 1.54 μM for HCT-116 cells. MMP-9-IN-12 induces cell apoptosis, ROS production and mitochondrial depolarization. MMP-9-IN-12 inhibits cells migration and disrupts cell cycle progression. MMP-9-IN-12 can be used for the research of colorectal cancer (CRC).
For research use only. We do not sell to patients.
- Formula: C28H24ClN3O5
- Molecular Weight:517.96
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MMP-9 6.57 μM (IC50) |
MMP-9-IN-12 (compound 10 g) displays an IC50 value of 1.54 μM in HCT-116 cancer cell line while maintaining moderate activity of 14.41-24.35 μM in the remaining cancer cell lines[1].
MMP-9-IN-12 (0.77-3.08 μM, 48 h) induces apoptosis, ROS production and mitochondrial depolarization, in HCT-116 cells[1].
MMP-9-IN-12 (0.77-3.08 μM, 48 h) dose-dependently decreases the number of colony formations in HCT-116 cells[1].
MMP-9-IN-12 (0.77-3.08 μM, 48 h) reduces cell population in the S and G2 phases while increasing in the G0/G1 phase in HCT-116 cells[1].
MMP-9-IN-12 (0.77-3.08 μM, 48 h) reduces MMP9 expression in HCT-116 cells[1].
MMP-9-IN-12 (0.77-3.08 μM, 48 h) inhibits cells migration in HCT-116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116 cells
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Concentration:0.77, 1.54 and 3.08 μM
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Incubation Time:48 h
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Result:Increased apoptosis in a dose-dependent manner.
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Cell Line:HCT-116 cells
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Concentration:0.77, 1.54 and 3.08 μM
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Incubation Time:48 h
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Result:Reduced cell population in the S and G2 phases while increasing in the G0/G1 phase.
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Cell Line:HCT-116 cells
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Concentration:0.77, 1.54 and 3.08 μM
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Incubation Time:48 h
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Result:Reduced MMP9 expression.
Chemical Information
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Molecular Weight 517.96
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Formula C28H24ClN3O5
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SMILES
COC1=C(OCC2=NN=C(C3=CC=CC=C3Cl)O2)C(C4)=C(C=C1)CC5N4CCC6=CC7=C(OCO7)C=C56
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MMP-9-IN-12 Related Classifications
HY-175558 Related Classifications
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